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GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN COMPLEXED WITH A PHOSPHOTYROSYL PENTAPEPTIDE
分子名称:	EPIDERMAL GROWTH FACTOR RECEPTOR-DERIVED PEPTIDE, GROWTH FACTOR RECEPTOR BINDING PROTEIN, ZINC ION
著者	Rahuel, J.
登録日	1998-03-26
公開日	1999-03-30
最終更新日	2023-11-15
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Structural basis for the high affinity of amino-aromatic SH2 phosphopeptide ligands. J.Mol.Biol., 279, 1998

2V12

Crystal Structure of Renin with Inhibitor 8
分子名称:	N-[(2S,4S,5S,7R)-4-AMINO-8-(BUTYLAMINO)-5-HYDROXY-7-METHYL-2-(1-METHYLETHYL)-8-OXOOCTYL]-2-(3-METHOXYPROPOXY)BENZAMIDE, RENIN
著者	Rahuel, J, Rasetti, V, Maibaum, J, Rueger, H, Goschke, R, Cohen, N.C, Stutz, S, Cumin, F, Fuhrer, W, Wood, J.M, Grutter, M.G.
登録日	2007-05-21
公開日	2007-07-03
最終更新日	2019-04-03
実験手法	X-RAY DIFFRACTION (3.2 Å)
主引用文献	Structure-Based Drug Design: The Discovery of Novel Nonpeptide Orally Active Inhibitors of Human Renin Chem.Biol., 7, 2000

2V11

Crystal Structure of Renin with Inhibitor 6
分子名称:	(2S,4S,5R,7R)-4-AMINO-8-(BUTYLAMINO)-5-HYDROXY-2,7-DIMETHYL-8-OXOOCTYL 1-BENZYL-1H-INDOLE-3-CARBOXYLATE, RENIN
著者	Rahuel, J, Rasetti, V, Maibaum, J, Rueger, H, Goschke, R, Cohen, N.C, Stutz, S, Cumin, F, Fuhrer, W, Wood, J.M, Grutter, M.G.
登録日	2007-05-21
公開日	2007-07-03
最終更新日	2019-04-03
実験手法	X-RAY DIFFRACTION (3.1 Å)
主引用文献	Structure-Based Drug Design: The Discovery of Novel Nonpeptide Orally Active Inhibitors of Human Renin Chem.Biol., 7, 2000

2V0Z

Crystal Structure of Renin with Inhibitor 10 (Aliskiren)
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, ALISKIREN, RENIN
著者	Rahuel, J, Rasetti, V, Maibaum, J, Rueger, H, Goschke, R, Cohen, N.C, Stutz, S, Cumin, F, Fuhrer, W, Wood, J.M, Grutter, M.G.
登録日	2007-05-21
公開日	2007-07-03
最終更新日	2020-07-29
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Structure-Based Drug Design: The Discovery of Novel Nonpeptide Orally Active Inhibitors of Human Renin Chem.Biol., 7, 2000

2V16

Crystal Structure of Renin with Inhibitor 3
分子名称:	METHYL (3R)-1-[(5S,6S,8R)-5-AMINO-9-BUTYLAMINO-6-HYDROXY-3,3,8-TRIMETHYL-9-OXO-NONANOYL]-3,4-DIHYDRO-2H-QUINOLINE-3-CARBOXYLATE, RENIN
著者	Rahuel, J, Rasetti, V, Maibaum, J, Rueger, H, Goschke, R, Cohen, N.C, Stutz, S, Cumin, F, Fuhrer, W, Wood, J.M, Grutter, M.G.
登録日	2007-05-22
公開日	2008-07-08
最終更新日	2019-04-03
実験手法	X-RAY DIFFRACTION (2.8 Å)
主引用文献	Structure-Based Drug Design: The Discovery of Novel Nonpeptide Orally Active Inhibitors of Human Renin Chem.Biol., 7, 2000

2V13

Crystal Structure of Renin with Inhibitor 7
分子名称:	N-[(2R,4S,5S,7R)-4-AMINO-8-(BUTYLAMINO)-5-HYDROXY-2,7-DIMETHYL-8-OXOOCTYL]-2-(3-METHOXYPROPOXY)BENZAMIDE, RENIN
著者	Rahuel, J, Rasetti, V, Maibaum, J, Rueger, H, Goschke, R, Cohen, N.C, Stutz, S, Cumin, F, Fuhrer, W, Wood, J.M, Grutter, M.G.
登録日	2007-05-21
公開日	2008-07-08
最終更新日	2019-04-03
実験手法	X-RAY DIFFRACTION (2.8 Å)
主引用文献	Structure-Based Drug Design: The Discovery of Novel Nonpeptide Orally Active Inhibitors of Human Renin Chem.Biol., 7, 2000

2V10

Crystal Structure of Renin with Inhibitor 9
分子名称:	(2R,4S,5S,7S)-5-AMINO-N-BUTYL-4-HYDROXY-7-[4-METHOXY-3-(3-METHOXYPROPOXY)BENZYL]-2,8-DIMETHYLNONANAMIDE, RENIN
著者	Rahuel, J, Rasetti, V, Maibaum, J, Rueger, H, Goschke, R, Cohen, N.C, Stutz, S, Cumin, F, Fuhrer, W, Wood, J.M, Grutter, M.G.
登録日	2007-05-21
公開日	2007-07-03
最終更新日	2019-04-03
実験手法	X-RAY DIFFRACTION (3.1 Å)
主引用文献	Structure-Based Drug Design: The Discovery of Novel Nonpeptide Orally Active Inhibitors of Human Renin Chem.Biol., 7, 2000

1TZE

SIGNAL TRANSDUCTION ADAPTOR GROWTH FACTOR, GRB2 SH2 DOMAIN COMPLEXED WITH PHOSPHOTYROSYL HEPTAPEPTIDE LYS-PRO-PHE-PTYR-VAL-ASN-VAL-NH2 (KFPPYVNC-NH2)
分子名称:	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, PHOSPHOTYROSYL HEPTAPEPTIDE LYS-PRO-PHE-PTYR-VAL-ASN-VAL-NH2
著者	Rahuel, J, Grutter, M.G.
登録日	1996-06-06
公開日	1997-07-07
最終更新日	2024-06-05
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	Structural basis for specificity of Grb2-SH2 revealed by a novel ligand binding mode. Nat.Struct.Biol., 3, 1996

1CJ1

GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN (HUMAN) COMPLEXED WITH A PHOSPHOTYROSYL DERIVATIVE
分子名称:	PROTEIN (GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2), [1-[1-(6-CARBAMOYL-CYCLOHEX-2-ENYLCARBAMOYL)-CYCLOHEXYLCARBAMOYL]-2-(4-PHOSPHONOOXY-PHENYL)- ETHYL]-CARBAMIC ACID 3-AMINOBENZYLESTER
著者	Rahuel, J.
登録日	1999-04-21
公開日	1999-12-22
最終更新日	2023-08-02
実験手法	X-RAY DIFFRACTION (3 Å)
主引用文献	Structure-based design, synthesis, and X-ray crystallography of a high-affinity antagonist of the Grb2-SH2 domain containing an asparagine mimetic. J.Med.Chem., 42, 1999

1RNE

THE CRYSTAL STRUCTURE OF RECOMBINANT GLYCOSYLATED HUMAN RENIN ALONE AND IN COMPLEX WITH A TRANSITION STATE ANALOG INHIBITOR
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, RENIN, [[[3-(2-METHYL-PROPANE-2-SULFONYL)-1-BENZENYL]-2-PROPYL]-CARBONYL-HISTIDYL]-AMINO-[CYCLOHEXYLMETHYL]-[2-HYDROXY-4-ISOPROPYL]-PENTAN-5-OIC ACID BUTYLAMIDE
著者	Gruetter, M.G, Rahuel, J, Priestle, J.P.
登録日	1991-12-12
公開日	1993-10-31
最終更新日	2020-10-21
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	The crystal structures of recombinant glycosylated human renin alone and in complex with a transition state analog inhibitor. J.Struct.Biol., 107, 1991

2JED

The crystal structure of the kinase domain of the protein kinase C theta in complex with NVP-XAA228 at 2.32A resolution.
分子名称:	(4S)-2-METHYL-2,4-PENTANEDIOL, 3-(8-DIMETHYLAMINOMETHYL-6,7,8,9-TETRAHYDRO-PYRIDO[1,2-A]INDOL-10-YL)-4-(1-METHYL-1H-INDOL-3-YL)-PYRROLE-2,5-DIONE, PROTEIN KINASE C THETA
著者	Stark, W, Bitsch, F, Berner, A, Buelens, F, Graff, P, Depersin, H, Geiser, M, Knecht, R, Rahuel, J, Rummel, G, Schlaeppi, J.M, Schmitz, R, Strauss, A, Wagner, J.
登録日	2007-01-16
公開日	2008-02-05
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (2.32 Å)
主引用文献	The Crystal Structure of the Kinase Domain of the Protein Kinase C Theta in Complex with Nvp-Xaa228 To be Published

1TMT

CHANGES IN INTERACTIONS IN COMPLEXES OF HIRUDIN DERIVATIVES AND HUMAN ALPHA-THROMBIN DUE TO DIFFERENT CRYSTAL FORMS
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), ...
著者	Priestle, J.P, Gruetter, M.G.
登録日	1994-05-26
公開日	1994-09-30
最終更新日	2022-12-21
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Changes in interactions in complexes of hirudin derivatives and human alpha-thrombin due to different crystal forms. Protein Sci., 2, 1993

1TMU

Changes in interactions in complexes of hirudin derivatives and human alpha-thrombin due to different crystal forms
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, Hirudin variant-2, ...
著者	Priestle, J.P, Gruetter, M.G.
登録日	1994-05-26
公開日	1994-09-30
最終更新日	2020-07-29
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Changes in interactions in complexes of hirudin derivatives and human alpha-thrombin due to different crystal forms. Protein Sci., 2, 1993

1SBN

REFINED CRYSTAL STRUCTURES OF SUBTILISIN NOVO IN COMPLEX WITH WILD-TYPE AND TWO MUTANT EGLINS. COMPARISON WITH OTHER SERINE PROTEINASE INHIBITOR COMPLEXES
分子名称:	CALCIUM ION, EGLIN C, SUBTILISIN NOVO BPN'
著者	Gruetter, M.G, Heinz, D.W, Priestle, J.P.
登録日	1991-12-20
公開日	1994-01-31
最終更新日	2024-02-14
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	Refined crystal structures of subtilisin novo in complex with wild-type and two mutant eglins. Comparison with other serine proteinase inhibitor complexes. J.Mol.Biol., 217, 1991

1SIB

REFINED CRYSTAL STRUCTURES OF SUBTILISIN NOVO IN COMPLEX WITH WILD-TYPE AND TWO MUTANT EGLINS. COMPARISON WITH OTHER SERINE PROTEINASE INHIBITOR COMPLEXES
分子名称:	CALCIUM ION, EGLIN C, SUBTILISIN NOVO BPN'
著者	Gruetter, M.G, Heinz, D.W, Priestle, J.P.
登録日	1993-08-02
公開日	1993-10-31
最終更新日	2024-02-14
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	Refined crystal structures of subtilisin novo in complex with wild-type and two mutant eglins. Comparison with other serine proteinase inhibitor complexes. J.Mol.Biol., 217, 1991

1DWE

Crystallographic analysis at 3.0-Angstroms resolution of the binding to human thrombin of four active site-directed inhibitors
分子名称:	ALPHA-THROMBIN heavy chain, ALPHA-THROMBIN light chain, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ...
著者	Banner, D.W, Hadvary, P.
登録日	1992-08-19
公開日	1994-01-31
最終更新日	2024-06-05
実験手法	X-RAY DIFFRACTION (3 Å)
主引用文献	Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors. J.Biol.Chem., 266, 1991

1DWB

CRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS
分子名称:	ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), BENZAMIDINE, ...
著者	Banner, D.W, Hadvary, P.
登録日	1992-08-19
公開日	1994-01-31
最終更新日	2024-06-05
実験手法	X-RAY DIFFRACTION (3.16 Å)
主引用文献	Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors. J.Biol.Chem., 266, 1991

1DWD

CRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS
分子名称:	1-[N-(naphthalen-2-ylsulfonyl)glycyl-4-carbamimidoyl-D-phenylalanyl]piperidine, ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), ...
著者	Banner, D.W, Hadvary, P.
登録日	1992-08-19
公開日	1994-01-31
最終更新日	2024-06-05
実験手法	X-RAY DIFFRACTION (3 Å)
主引用文献	Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors. J.Biol.Chem., 266, 1991

1DWC

CRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS
分子名称:	ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), HIRUDIN IIIA, ...
著者	Banner, D.W, Hadvary, P.
登録日	1992-08-19
公開日	1994-01-31
最終更新日	2024-06-05
実験手法	X-RAY DIFFRACTION (3 Å)
主引用文献	Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors. J.Biol.Chem., 266, 1991

1TBR

CRYSTAL STRUCTURE OF INSECT DERIVED DOUBLE DOMAIN KAZAL INHIBITOR RHODNIIN IN COMPLEX WITH THROMBIN
分子名称:	RHODNIIN, THROMBIN
著者	Van De Locht, A, Lamba, D, Bode, W.
登録日	1995-03-03
公開日	1996-10-14
最終更新日	2011-07-13
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	Two heads are better than one: crystal structure of the insect derived double domain Kazal inhibitor rhodniin in complex with thrombin. EMBO J., 14, 1995

1TBQ

CRYSTAL STRUCTURE OF INSECT DERIVED DOUBLE DOMAIN KAZAL INHIBITOR RHODNIIN IN COMPLEX WITH THROMBIN
分子名称:	RHODNIIN, THROMBIN
著者	Van De Locht, A, Lamba, D, Bode, W.
登録日	1995-03-02
公開日	1996-10-14
最終更新日	2011-07-13
実験手法	X-RAY DIFFRACTION (3.1 Å)
主引用文献	Two heads are better than one: crystal structure of the insect derived double domain Kazal inhibitor rhodniin in complex with thrombin. EMBO J., 14, 1995

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