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4N3W
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BU of 4n3w by Molmil
Crystal Structure of the Bromodomain-PHD Finger Module of Human Transcriptional Co-Activator CBP in complex with Acetylated Histone 4 Peptide (H4K20ac).
分子名称: CREB-binding protein, Histone H4 peptide, ZINC ION
著者Plotnikov, A.N, Yang, S, Zhou, M.-M.
登録日2013-10-07
公開日2014-01-29
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Insights into Acetylated-Histone H4 Recognition by the Bromodomain-PHD Finger Module of Human Transcriptional Coactivator CBP.
Structure, 22, 2014
4N4F
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BU of 4n4f by Molmil
Crystal Structure of the Bromodomain-PHD Finger Module of Human Transcriptional Co-Activator CBP in complex with di-Acetylated Histone 4 Peptide (H412acK16ac).
分子名称: CREB-binding protein, Histone 4 Peptide, ZINC ION
著者Plotnikov, A.N, Zhou, J, Zhou, M.-M.
登録日2013-10-08
公開日2014-02-19
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Structural Insights into Acetylated-Histone H4 Recognition by the Bromodomain-PHD Finger Module of Human Transcriptional Coactivator CBP.
Structure, 22, 2014
1CVS
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BU of 1cvs by Molmil
CRYSTAL STRUCTURE OF A DIMERIC FGF2-FGFR1 COMPLEX
分子名称: FIBROBLAST GROWTH FACTOR 2, FIBROBLAST GROWTH FACTOR RECEPTOR 1, SULFATE ION
著者Plotnikov, A.N, Schlessinger, J, Hubbard, S.R, Mohammadi, M.
登録日1999-08-24
公開日2000-01-28
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural basis for FGF receptor dimerization and activation.
Cell(Cambridge,Mass.), 98, 1999
1EVT
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BU of 1evt by Molmil
CRYSTAL STRUCTURE OF FGF1 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 1 (FGFR1)
分子名称: PROTEIN (FIBROBLAST GROWTH FACTOR 1), PROTEIN (FIBROBLAST GROWTH FACTOR RECEPTOR 1), SULFATE ION
著者Plotnikov, A.N, Hubbard, S.R, Schlessinger, J, Mohammadi, M.
登録日2000-04-20
公開日2000-05-31
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Cell(Cambridge,Mass.), 101, 2000
1EV2
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BU of 1ev2 by Molmil
CRYSTAL STRUCTURE OF FGF2 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 2 (FGFR2)
分子名称: PROTEIN (FIBROBLAST GROWTH FACTOR 2), PROTEIN (FIBROBLAST GROWTH FACTOR RECEPTOR 2), SULFATE ION
著者Plotnikov, A.N, Hubbard, S.R, Schlessinger, J, Mohammadi, M.
登録日2000-04-19
公開日2000-05-31
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Cell(Cambridge,Mass.), 101, 2000
1IHK
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BU of 1ihk by Molmil
CRYSTAL STRUCTURE OF FIBROBLAST GROWTH FACTOR 9 (FGF9)
分子名称: GLIA-ACTIVATING FACTOR, PHOSPHATE ION
著者Plotnikov, A.N, Eliseenkova, A.V, Ibrahimi, O.A, Lemmon, M.A, Mohammadi, M.
登録日2001-04-19
公開日2001-05-02
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of fibroblast growth factor 9 reveals regions implicated in dimerization and autoinhibition.
J.Biol.Chem., 276, 2001
5ULA
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BU of 5ula by Molmil
Crystal Structure of the First Bromodomain of Human BRD4 in Complex With Cyclic Vinylogous Amide Inhibitor MS402
分子名称: 3-chloranyl-~{N}-(4-methoxyphenyl)-4-[(2-methyl-3-oxidanylidene-cyclopenten-1-yl)amino]benzamide, Bromodomain-containing protein 4
著者Plotnikov, A.N, Joshua, j, Zhou, M.-M.
登録日2017-01-24
公開日2017-03-22
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4NUD
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BU of 4nud by Molmil
Crystal structure of the first bromodomain of human BRD4 in complex with MS436 inhibitor
分子名称: 1,2-ETHANEDIOL, 4-[(E)-(2-amino-4-hydroxy-5-methylphenyl)diazenyl]-N-(pyridin-2-yl)benzenesulfonamide, Bromodomain-containing protein 4
著者Plotnikov, A.N, Joshua, J, Zhou, M.-M.
登録日2013-12-03
公開日2014-04-02
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains
J.Med.Chem., 56, 2013
4QB3
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BU of 4qb3 by Molmil
Crystal structure of the first bromodomain of human BRD4 in complex with Olinone
分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, N-[4-(1-oxo-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)butyl]acetamide
著者Plotnikov, A.N, Joshua, J, Zhou, M.-M.
登録日2014-05-06
公開日2015-04-22
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (0.94 Å)
主引用文献Selective chemical modulation of gene transcription favors oligodendrocyte lineage progression.
Chem.Biol., 21, 2014
4NUC
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BU of 4nuc by Molmil
Crystal structure of the first bromodomain of human BRD4 in complex with MS435 inhibitor
分子名称: 1,2-ETHANEDIOL, 4-[(E)-(4-hydroxy-3,5-dimethylphenyl)diazenyl]-N-(pyridin-2-yl)benzenesulfonamide, Bromodomain-containing protein 4
著者Plotnikov, A.N, Joshua, J, Zhou, M.-M.
登録日2013-12-03
公開日2014-04-02
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains
J.Med.Chem., 56, 2013
4NUE
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BU of 4nue by Molmil
Crystal structure of the first bromodomain of human BRD4 in complex with MS267 inhibitor
分子名称: 1,2-ETHANEDIOL, 4-[(E)-(2-amino-4-hydroxy-3,5-dimethylphenyl)diazenyl]-N-(pyridin-2-yl)benzenesulfonamide, Bromodomain-containing protein 4
著者Plotnikov, A.N, Joshua, J, Zhou, M.-M.
登録日2013-12-03
公開日2014-04-02
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains
J.Med.Chem., 56, 2013
2PSW
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BU of 2psw by Molmil
Human MAK3 homolog in complex with CoA
分子名称: COENZYME A, N-acetyltransferase 13
著者Walker, J.R, Schuetz, A, Antoshenko, T, Wu, H, Bernstein, G, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC)
登録日2007-05-07
公開日2007-06-05
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure of Human MAK3 homolog.
To be Published
2PQT
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BU of 2pqt by Molmil
Human N-acetyltransferase 1
分子名称: Arylamine N-acetyltransferase 1, CHLORIDE ION, UNKNOWN ATOM OR ION
著者Tempel, W, Wu, H, Dombrovski, L, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Grant, D.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC)
登録日2007-05-02
公開日2007-05-15
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Structural Basis of Substrate-binding Specificity of Human Arylamine N-Acetyltransferases.
J.Biol.Chem., 282, 2007
2QPW
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BU of 2qpw by Molmil
Methyltransferase domain of human PR domain-containing protein 2
分子名称: PR domain zinc finger protein 2
著者Lunin, V.V, Wu, H, Dombrovski, L, Antoshenko, T, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Plotnikov, A.N, Structural Genomics Consortium (SGC)
登録日2007-07-25
公開日2007-08-14
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Structural biology of human H3K9 methyltransferases
Plos One, 5, 2010
2F2S
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BU of 2f2s by Molmil
Human mitochondrial acetoacetyl-CoA thiolase
分子名称: Acetyl-CoA acetyltransferase, mitochondrial, CHLORIDE ION, ...
著者Min, J.R, Dombrovski, L, Antoshenko, T, Wu, H, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC)
登録日2005-11-17
公開日2005-11-29
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The Crystal Structure of Human Mitochondrial Acetoacetyl-Coa Thiolase Acat1.
To be Published
2EX4
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BU of 2ex4 by Molmil
Crystal Structure of Human methyltransferase AD-003 in complex with S-adenosyl-L-homocysteine
分子名称: S-ADENOSYL-L-HOMOCYSTEINE, adrenal gland protein AD-003
著者Min, J.R, Wu, H, Zeng, H, Loppnau, P, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC)
登録日2005-11-07
公開日2005-11-15
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献The Crystal Structure of Human AD-003 protein in complex with S-adenosyl-L-homocysteine
To be Published
2FBM
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BU of 2fbm by Molmil
Acetyltransferase domain of CDY1
分子名称: CHLORIDE ION, Y chromosome chromodomain protein 1, telomeric isoform b
著者Min, J.R, Antoshenko, T, Hong, W, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC)
登録日2005-12-09
公開日2005-12-27
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Crystal Structure of Acetyltransferases domain of Human Testis-specific chromodomain protein Y 1
To be Published
4JS8
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BU of 4js8 by Molmil
Crystal structure of TTK kinase domain with an inhibitor: 401348
分子名称: 4-(cyclohexylmethoxy)-3-{4-[(1-methylpiperidin-4-yl)oxy]phenyl}-2H-indazole, DI(HYDROXYETHYL)ETHER, Dual specificity protein kinase TTK, ...
著者Qiu, W, Plotnikov, A.N, Plotnikova, O, Feher, M, Awrey, D.E, Chirgadze, N.Y.
登録日2013-03-22
公開日2014-03-26
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Crystal structure of TTK kinase domain with an inhibitor: 401348
To be Published
3ORH
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BU of 3orh by Molmil
Human guanidinoacetate N-methyltransferase with SAH
分子名称: Guanidinoacetate N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
著者Dong, A, Wu, H, Zeng, H, Loppnau, P, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC)
登録日2010-09-07
公開日2010-09-15
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献The crystal structure of human guanidinoacetate N-methyltransferase with SAH
TO BE PUBLISHED
1NUN
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BU of 1nun by Molmil
Crystal Structure Analysis of the FGF10-FGFR2b Complex
分子名称: Fibroblast growth factor-10, POLYETHYLENE GLYCOL (N=34), SULFATE ION, ...
著者Yeh, B.K, Igarashi, M, Eliseenkova, A.V, Plotnikov, A.N, Sher, I, Ron, D, Aaronson, S.A, Mohammadi, M.
登録日2003-01-31
公開日2003-02-11
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors.
Proc.Natl.Acad.Sci.USA, 100, 2003
4F3I
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BU of 4f3i by Molmil
Crystal structure of the first bromodomain of human BRD4 in complex with MS417 inhibitor
分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, methyl [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate
著者Joshua, J, Zhou, M.-M, Plotnikov, A.N.
登録日2012-05-09
公開日2012-09-12
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Down-regulation of NF-{kappa}B Transcriptional Activity in HIV-associated Kidney Disease by BRD4 Inhibition.
J.Biol.Chem., 287, 2012
3BFX
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BU of 3bfx by Molmil
Crystal structure of human sulfotransferase SULT1C1 in complex with PAP
分子名称: ADENOSINE-3'-5'-DIPHOSPHATE, Sulfotransferase 1C2
著者Dong, A, Dombrovski, L, Loppnau, P, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC)
登録日2007-11-23
公開日2007-12-04
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal Structures of Human Sulfotransferases Sult1B1 and Sult1C1 Complexed with the Cofactor Product Adenosine-3'-5'-Diphosphate (Pap).
Proteins, 64, 2006
3C0Z
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BU of 3c0z by Molmil
Crystal structure of catalytic domain of human histone deacetylase HDAC7 in complex with SAHA
分子名称: Histone deacetylase 7a, OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE, POTASSIUM ION, ...
著者Min, J, Schuetz, A, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC)
登録日2008-01-21
公開日2008-02-19
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity.
J.Biol.Chem., 283, 2008
3BO5
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BU of 3bo5 by Molmil
Crystal structure of methyltransferase domain of human Histone-lysine N-methyltransferase SETMAR
分子名称: GLYCEROL, Histone-lysine N-methyltransferase SETMAR, S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Lunin, V.V, Wu, H, Ren, H, Dobrovetsky, E, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Plotnikov, A.N, Structural Genomics Consortium (SGC)
登録日2007-12-17
公開日2008-01-22
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献The Crystal Structure of Methyltransferase Domain of Human Histone-lysine N-methyltransferase SETMAR in Complex With AdoHcy.
To be Published
3C6G
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Crystal structure of CYP2R1 in complex with vitamin D3
分子名称: (1S,3Z)-3-[(2E)-2-[(1R,3AR,7AS)-7A-METHYL-1-[(2R)-6-METHYLHEPTAN-2-YL]-2,3,3A,5,6,7-HEXAHYDRO-1H-INDEN-4-YLIDENE]ETHYLI DENE]-4-METHYLIDENE-CYCLOHEXAN-1-OL, Cycloheptakis-(1-4)-(alpha-D-glucopyranose), Cytochrome P450 2R1, ...
著者Strushkevich, N.V, Min, J, Loppnau, P, Tempel, W, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Plotnikov, A.N, Park, H, Structural Genomics Consortium (SGC)
登録日2008-02-04
公開日2008-02-19
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural analysis of CYP2R1 in complex with vitamin D3.
J.Mol.Biol., 380, 2008

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