4N3W
| |
4N4F
| |
1CVS
| CRYSTAL STRUCTURE OF A DIMERIC FGF2-FGFR1 COMPLEX | 分子名称: | FIBROBLAST GROWTH FACTOR 2, FIBROBLAST GROWTH FACTOR RECEPTOR 1, SULFATE ION | 著者 | Plotnikov, A.N, Schlessinger, J, Hubbard, S.R, Mohammadi, M. | 登録日 | 1999-08-24 | 公開日 | 2000-01-28 | 最終更新日 | 2024-11-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural basis for FGF receptor dimerization and activation. Cell(Cambridge,Mass.), 98, 1999
|
|
1EVT
| CRYSTAL STRUCTURE OF FGF1 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 1 (FGFR1) | 分子名称: | PROTEIN (FIBROBLAST GROWTH FACTOR 1), PROTEIN (FIBROBLAST GROWTH FACTOR RECEPTOR 1), SULFATE ION | 著者 | Plotnikov, A.N, Hubbard, S.R, Schlessinger, J, Mohammadi, M. | 登録日 | 2000-04-20 | 公開日 | 2000-05-31 | 最終更新日 | 2024-11-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. Cell(Cambridge,Mass.), 101, 2000
|
|
1EV2
| CRYSTAL STRUCTURE OF FGF2 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 2 (FGFR2) | 分子名称: | PROTEIN (FIBROBLAST GROWTH FACTOR 2), PROTEIN (FIBROBLAST GROWTH FACTOR RECEPTOR 2), SULFATE ION | 著者 | Plotnikov, A.N, Hubbard, S.R, Schlessinger, J, Mohammadi, M. | 登録日 | 2000-04-19 | 公開日 | 2000-05-31 | 最終更新日 | 2024-11-06 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. Cell(Cambridge,Mass.), 101, 2000
|
|
1IHK
| CRYSTAL STRUCTURE OF FIBROBLAST GROWTH FACTOR 9 (FGF9) | 分子名称: | GLIA-ACTIVATING FACTOR, PHOSPHATE ION | 著者 | Plotnikov, A.N, Eliseenkova, A.V, Ibrahimi, O.A, Lemmon, M.A, Mohammadi, M. | 登録日 | 2001-04-19 | 公開日 | 2001-05-02 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of fibroblast growth factor 9 reveals regions implicated in dimerization and autoinhibition. J.Biol.Chem., 276, 2001
|
|
5ULA
| |
4NUD
| Crystal structure of the first bromodomain of human BRD4 in complex with MS436 inhibitor | 分子名称: | 1,2-ETHANEDIOL, 4-[(E)-(2-amino-4-hydroxy-5-methylphenyl)diazenyl]-N-(pyridin-2-yl)benzenesulfonamide, Bromodomain-containing protein 4 | 著者 | Plotnikov, A.N, Joshua, J, Zhou, M.-M. | 登録日 | 2013-12-03 | 公開日 | 2014-04-02 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains J.Med.Chem., 56, 2013
|
|
4QB3
| Crystal structure of the first bromodomain of human BRD4 in complex with Olinone | 分子名称: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, N-[4-(1-oxo-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)butyl]acetamide | 著者 | Plotnikov, A.N, Joshua, J, Zhou, M.-M. | 登録日 | 2014-05-06 | 公開日 | 2015-04-22 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (0.94 Å) | 主引用文献 | Selective chemical modulation of gene transcription favors oligodendrocyte lineage progression. Chem.Biol., 21, 2014
|
|
4NUC
| Crystal structure of the first bromodomain of human BRD4 in complex with MS435 inhibitor | 分子名称: | 1,2-ETHANEDIOL, 4-[(E)-(4-hydroxy-3,5-dimethylphenyl)diazenyl]-N-(pyridin-2-yl)benzenesulfonamide, Bromodomain-containing protein 4 | 著者 | Plotnikov, A.N, Joshua, J, Zhou, M.-M. | 登録日 | 2013-12-03 | 公開日 | 2014-04-02 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains J.Med.Chem., 56, 2013
|
|
4NUE
| Crystal structure of the first bromodomain of human BRD4 in complex with MS267 inhibitor | 分子名称: | 1,2-ETHANEDIOL, 4-[(E)-(2-amino-4-hydroxy-3,5-dimethylphenyl)diazenyl]-N-(pyridin-2-yl)benzenesulfonamide, Bromodomain-containing protein 4 | 著者 | Plotnikov, A.N, Joshua, J, Zhou, M.-M. | 登録日 | 2013-12-03 | 公開日 | 2014-04-02 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains J.Med.Chem., 56, 2013
|
|
2PSW
| Human MAK3 homolog in complex with CoA | 分子名称: | COENZYME A, N-acetyltransferase 13 | 著者 | Walker, J.R, Schuetz, A, Antoshenko, T, Wu, H, Bernstein, G, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | 登録日 | 2007-05-07 | 公開日 | 2007-06-05 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure of Human MAK3 homolog. To be Published
|
|
2PQT
| Human N-acetyltransferase 1 | 分子名称: | Arylamine N-acetyltransferase 1, CHLORIDE ION, UNKNOWN ATOM OR ION | 著者 | Tempel, W, Wu, H, Dombrovski, L, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Grant, D.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | 登録日 | 2007-05-02 | 公開日 | 2007-05-15 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Structural Basis of Substrate-binding Specificity of Human Arylamine N-Acetyltransferases. J.Biol.Chem., 282, 2007
|
|
2QPW
| Methyltransferase domain of human PR domain-containing protein 2 | 分子名称: | PR domain zinc finger protein 2 | 著者 | Lunin, V.V, Wu, H, Dombrovski, L, Antoshenko, T, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Plotnikov, A.N, Structural Genomics Consortium (SGC) | 登録日 | 2007-07-25 | 公開日 | 2007-08-14 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Structural biology of human H3K9 methyltransferases Plos One, 5, 2010
|
|
2F2S
| Human mitochondrial acetoacetyl-CoA thiolase | 分子名称: | Acetyl-CoA acetyltransferase, mitochondrial, CHLORIDE ION, ... | 著者 | Min, J.R, Dombrovski, L, Antoshenko, T, Wu, H, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | 登録日 | 2005-11-17 | 公開日 | 2005-11-29 | 最終更新日 | 2024-10-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The Crystal Structure of Human Mitochondrial Acetoacetyl-Coa Thiolase Acat1. To be Published
|
|
2EX4
| Crystal Structure of Human methyltransferase AD-003 in complex with S-adenosyl-L-homocysteine | 分子名称: | S-ADENOSYL-L-HOMOCYSTEINE, adrenal gland protein AD-003 | 著者 | Min, J.R, Wu, H, Zeng, H, Loppnau, P, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | 登録日 | 2005-11-07 | 公開日 | 2005-11-15 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | The Crystal Structure of Human AD-003 protein in complex with S-adenosyl-L-homocysteine To be Published
|
|
2FBM
| Acetyltransferase domain of CDY1 | 分子名称: | CHLORIDE ION, Y chromosome chromodomain protein 1, telomeric isoform b | 著者 | Min, J.R, Antoshenko, T, Hong, W, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | 登録日 | 2005-12-09 | 公開日 | 2005-12-27 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Crystal Structure of Acetyltransferases domain of Human Testis-specific chromodomain protein Y 1 To be Published
|
|
4JS8
| Crystal structure of TTK kinase domain with an inhibitor: 401348 | 分子名称: | 4-(cyclohexylmethoxy)-3-{4-[(1-methylpiperidin-4-yl)oxy]phenyl}-2H-indazole, DI(HYDROXYETHYL)ETHER, Dual specificity protein kinase TTK, ... | 著者 | Qiu, W, Plotnikov, A.N, Plotnikova, O, Feher, M, Awrey, D.E, Chirgadze, N.Y. | 登録日 | 2013-03-22 | 公開日 | 2014-03-26 | 最終更新日 | 2024-11-06 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Crystal structure of TTK kinase domain with an inhibitor: 401348 To be Published
|
|
3ORH
| Human guanidinoacetate N-methyltransferase with SAH | 分子名称: | Guanidinoacetate N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | 著者 | Dong, A, Wu, H, Zeng, H, Loppnau, P, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | 登録日 | 2010-09-07 | 公開日 | 2010-09-15 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | The crystal structure of human guanidinoacetate N-methyltransferase with SAH TO BE PUBLISHED
|
|
1NUN
| Crystal Structure Analysis of the FGF10-FGFR2b Complex | 分子名称: | Fibroblast growth factor-10, POLYETHYLENE GLYCOL (N=34), SULFATE ION, ... | 著者 | Yeh, B.K, Igarashi, M, Eliseenkova, A.V, Plotnikov, A.N, Sher, I, Ron, D, Aaronson, S.A, Mohammadi, M. | 登録日 | 2003-01-31 | 公開日 | 2003-02-11 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural basis by which alternative splicing confers
specificity in fibroblast growth factor receptors. Proc.Natl.Acad.Sci.USA, 100, 2003
|
|
4F3I
| Crystal structure of the first bromodomain of human BRD4 in complex with MS417 inhibitor | 分子名称: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, methyl [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate | 著者 | Joshua, J, Zhou, M.-M, Plotnikov, A.N. | 登録日 | 2012-05-09 | 公開日 | 2012-09-12 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Down-regulation of NF-{kappa}B Transcriptional Activity in HIV-associated Kidney Disease by BRD4 Inhibition. J.Biol.Chem., 287, 2012
|
|
3BFX
| Crystal structure of human sulfotransferase SULT1C1 in complex with PAP | 分子名称: | ADENOSINE-3'-5'-DIPHOSPHATE, Sulfotransferase 1C2 | 著者 | Dong, A, Dombrovski, L, Loppnau, P, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | 登録日 | 2007-11-23 | 公開日 | 2007-12-04 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal Structures of Human Sulfotransferases Sult1B1 and Sult1C1 Complexed with the Cofactor Product Adenosine-3'-5'-Diphosphate (Pap). Proteins, 64, 2006
|
|
3C0Z
| Crystal structure of catalytic domain of human histone deacetylase HDAC7 in complex with SAHA | 分子名称: | Histone deacetylase 7a, OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE, POTASSIUM ION, ... | 著者 | Min, J, Schuetz, A, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | 登録日 | 2008-01-21 | 公開日 | 2008-02-19 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity. J.Biol.Chem., 283, 2008
|
|
3BO5
| Crystal structure of methyltransferase domain of human Histone-lysine N-methyltransferase SETMAR | 分子名称: | GLYCEROL, Histone-lysine N-methyltransferase SETMAR, S-ADENOSYL-L-HOMOCYSTEINE, ... | 著者 | Lunin, V.V, Wu, H, Ren, H, Dobrovetsky, E, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Plotnikov, A.N, Structural Genomics Consortium (SGC) | 登録日 | 2007-12-17 | 公開日 | 2008-01-22 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | The Crystal Structure of Methyltransferase Domain of Human Histone-lysine N-methyltransferase SETMAR in Complex With AdoHcy. To be Published
|
|
3C6G
| Crystal structure of CYP2R1 in complex with vitamin D3 | 分子名称: | (1S,3Z)-3-[(2E)-2-[(1R,3AR,7AS)-7A-METHYL-1-[(2R)-6-METHYLHEPTAN-2-YL]-2,3,3A,5,6,7-HEXAHYDRO-1H-INDEN-4-YLIDENE]ETHYLI DENE]-4-METHYLIDENE-CYCLOHEXAN-1-OL, Cycloheptakis-(1-4)-(alpha-D-glucopyranose), Cytochrome P450 2R1, ... | 著者 | Strushkevich, N.V, Min, J, Loppnau, P, Tempel, W, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Plotnikov, A.N, Park, H, Structural Genomics Consortium (SGC) | 登録日 | 2008-02-04 | 公開日 | 2008-02-19 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural analysis of CYP2R1 in complex with vitamin D3. J.Mol.Biol., 380, 2008
|
|