7N3V
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7SHW
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7KXW
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![BU of 7kxw by Molmil](/molmil-images/mine/7kxw) | Crystal structure of DCLK1-KD in complex with DCLK1-IN-1 | 分子名称: | 2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}-11-methyl-5-(2,2,2-trifluoroethyl)-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, DI(HYDROXYETHYL)ETHER, Serine/threonine-protein kinase DCLK1, ... | 著者 | Patel, O, Lucet, I. | 登録日 | 2020-12-05 | 公開日 | 2021-09-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.002 Å) | 主引用文献 | Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1. Commun Biol, 4, 2021
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7KX8
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![BU of 7kx8 by Molmil](/molmil-images/mine/7kx8) | Crystal structure of DCLK1-Cter in complex with FMF-03-055-1 | 分子名称: | 5-ethyl-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}-11-methyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, Serine/threonine-protein kinase DCLK1 | 著者 | Patel, O, Lucet, I. | 登録日 | 2020-12-03 | 公開日 | 2021-09-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1. Commun Biol, 4, 2021
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7KX6
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![BU of 7kx6 by Molmil](/molmil-images/mine/7kx6) | Crystal structure of DCLK1-KD in complex with XMD8-85 | 分子名称: | 2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, Serine/threonine-protein kinase DCLK1 | 著者 | Patel, O, Lucet, I. | 登録日 | 2020-12-03 | 公開日 | 2021-09-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1. Commun Biol, 4, 2021
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5JZJ
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5JZN
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![BU of 5jzn by Molmil](/molmil-images/mine/5jzn) | Crystal structure of DCLK1-KD in complex with NVP-TAE684 | 分子名称: | 5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL)PIPERIDIN-1-YL]PHENYL]-N'-(2-PROPAN-2-YLSULFONYLPHENYL)PYRIMIDINE-2,4-DIAMINE, SULFATE ION, Serine/threonine-protein kinase DCLK1 | 著者 | Patel, O, Lucet, I. | 登録日 | 2016-05-17 | 公開日 | 2016-08-24 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Biochemical and Structural Insights into Doublecortin-like Kinase Domain 1. Structure, 24, 2016
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4L4T
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![BU of 4l4t by Molmil](/molmil-images/mine/4l4t) | Structure of human MAIT TCR in complex with human MR1-6-FP | 分子名称: | 2-amino-4-oxo-3,4-dihydropteridine-6-carbaldehyde, Beta-2-microglobulin, MAIT T-cell receptor alpha chain, ... | 著者 | Patel, O, Kjer-Nielsen, L, Le Nours, J, Eckle, S.B.G, Birkinshaw, R.W, Beddoe, T, Corbett, A.J, Liu, L, Miles, J.J, Meehan, B, Reantragoon, R, Sandoval-Romero, M.L, Sullivan, L.C, Brooks, A.G, Chen, Z, Fairlie, D.P, McCluskey, J, Rossjohn, J. | 登録日 | 2013-06-09 | 公開日 | 2013-07-17 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Recognition of vitamin B metabolites by mucosal-associated invariant T cells. Nat Commun, 4, 2013
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4L4V
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![BU of 4l4v by Molmil](/molmil-images/mine/4l4v) | Structure of human MAIT TCR in complex with human MR1-RL-6-Me-7-OH | 分子名称: | 1-deoxy-1-(7-hydroxy-6-methyl-2,4-dioxo-3,4-dihydropteridin-8(2H)-yl)-D-ribitol, Beta-2-microglobulin, GLYCEROL, ... | 著者 | Patel, O, Kjer-Nielsen, L, Le Nours, J, Eckle, S.B.G, Birkinshaw, R.W, Beddoe, T, Corbett, A.J, Liu, L, Miles, J.J, Meehan, B, Reantragoon, R, Sandoval-Romero, M.L, Sullivan, L.C, Brooks, A.G, Chen, Z, Fairlie, D.P, McCluskey, J, Rossjohn, J. | 登録日 | 2013-06-09 | 公開日 | 2013-07-17 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Recognition of vitamin B metabolites by mucosal-associated invariant T cells. Nat Commun, 4, 2013
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5VE6
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4EI5
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![BU of 4ei5 by Molmil](/molmil-images/mine/4ei5) | Crystal Structure of XV19 TCR in complex with CD1d-sulfatide C24:1 | 分子名称: | (15Z)-N-((1S,2R,3E)-2-HYDROXY-1-{[(3-O-SULFO-BETA-D-GALACTOPYRANOSYL)OXY]METHYL}HEPTADEC-3-ENYL)TETRACOS-15-ENAMIDE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Patel, O, Gras, S, Rossjohn, J. | 登録日 | 2012-04-04 | 公開日 | 2012-07-25 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor. Nat.Immunol., 13, 2012
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4EI6
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![BU of 4ei6 by Molmil](/molmil-images/mine/4ei6) | Structure of XV19 Valpha1-Vbeta16 Type-II Natural Killer T cell receptor | 分子名称: | Valpha1 XV19 Type II Natural Killer T cell receptor (mouse variable domain, human constant domain), Vbeta16 XV19 Type II Natural Killer T cell receptor (mouse variable domain | 著者 | Patel, O, Rossjohn, J. | 登録日 | 2012-04-04 | 公開日 | 2012-07-25 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor. Nat.Immunol., 13, 2012
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3TN0
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3TO4
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![BU of 3to4 by Molmil](/molmil-images/mine/3to4) | Structure of mouse Valpha14Vbeta2-mouseCD1d-alpha-Galactosylceramide | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antigen-presenting glycoprotein CD1d1, ... | 著者 | Patel, O, Rossjohn, J. | 登録日 | 2011-09-04 | 公開日 | 2011-12-14 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Vbeta2 natural killer T cell antigen receptor-mediated recognition of CD1d-glycolipid antigen. Proc.Natl.Acad.Sci.USA, 108, 2011
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3HE6
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3HE7
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3AXL
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![BU of 3axl by Molmil](/molmil-images/mine/3axl) | Murine Valpha 10 Vbeta 8.1 T-cell receptor | 分子名称: | Valpha 10, Vbeta 8.1 | 著者 | Patel, O, Rossjohn, J. | 登録日 | 2011-04-11 | 公開日 | 2011-08-03 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | A semi-invariant V(alpha)10(+) T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties Nat.Immunol., 12, 2011
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4GUP
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![BU of 4gup by Molmil](/molmil-images/mine/4gup) | Structure of MHC-class I related molecule MR1 | 分子名称: | 2-amino-4-oxo-3,4-dihydropteridine-6-carbaldehyde, Beta-2-microglobulin, CHLORIDE ION, ... | 著者 | Patel, O, Le Nours, J, Rossjohn, J. | 登録日 | 2012-08-29 | 公開日 | 2012-10-17 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | MR1 presents microbial vitamin B metabolites to MAIT cells Nature, 491, 2012
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4LCW
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![BU of 4lcw by Molmil](/molmil-images/mine/4lcw) | The structure of human MAIT TCR in complex with MR1-K43A-RL-6-Me-7OH | 分子名称: | 1-deoxy-1-(7-hydroxy-6-methyl-2,4-dioxo-3,4-dihydropteridin-8(2H)-yl)-D-ribitol, Beta-2-microglobulin, GLYCEROL, ... | 著者 | Patel, O, Rossjohn, J. | 登録日 | 2013-06-24 | 公開日 | 2013-10-02 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells. J.Exp.Med., 210, 2013
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4DZB
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3RUG
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![BU of 3rug by Molmil](/molmil-images/mine/3rug) | Crystal structure of Valpha10-Vbeta8.1 NKT TCR in complex with CD1d-alphaglucosylceramide (C20:2) | 分子名称: | (11E,14E)-N-[(2S,3S,4R)-1-(alpha-D-glucopyranosyloxy)-3,4-dihydroxyoctadecan-2-yl]icosa-11,14-dienamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Patel, O, Rossjohn, J. | 登録日 | 2011-05-05 | 公開日 | 2011-08-03 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | A semi-invariant V(alpha)10(+) T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties Nat.Immunol., 12, 2011
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3EYH
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![BU of 3eyh by Molmil](/molmil-images/mine/3eyh) | Crystal structures of JAK1 and JAK2 inhibitor complexes | 分子名称: | 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE, Tyrosine-protein kinase | 著者 | Williams, N.K, Bamert, R.S, Patell, O, Wang, C, Walden, P.M, Fantino, E. | 登録日 | 2008-10-20 | 公開日 | 2009-02-03 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Dissecting specificity in the Janus kinases: the structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains. J.Mol.Biol., 387, 2009
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3EYG
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![BU of 3eyg by Molmil](/molmil-images/mine/3eyg) | Crystal structures of JAK1 and JAK2 inhibitor complexes | 分子名称: | 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile, Tyrosine-protein kinase | 著者 | Williams, N.K, Bamert, R.S, Patell, O, Wang, C, Walden, P.M, Fantino, E. | 登録日 | 2008-10-20 | 公開日 | 2009-02-03 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Dissecting specificity in the Janus kinases: the structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains. J.Mol.Biol., 387, 2009
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8DFY
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![BU of 8dfy by Molmil](/molmil-images/mine/8dfy) | Crystal structure of Human BTN2A1 Ectodomain | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Butyrophilin subfamily 2 member A1, ... | 著者 | Fulford, T.S, Soliman, C, Castle, R.G, Rigau, M, Ruan, Z, Dolezal, O, Seneviratna, R, Brown, H.G, Hanssen, E, Hammet, A, Li, S, Redmond, S.J, Chung, A, Gorman, M.A, Parker, M.W, Patel, O, Peat, T.S, Newman, J, Behren, A, Gherardin, N.A, Godfrey, D.I, Uldrich, A.P. | 登録日 | 2022-06-22 | 公開日 | 2023-07-05 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.552 Å) | 主引用文献 | Vgamma9-Vdelta2 T cells recognize butyrophilin 2A1 and 3A1 heteromers To Be Published
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8DFX
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![BU of 8dfx by Molmil](/molmil-images/mine/8dfx) | Crystal structure of Human BTN2A1-BTN3A1 Ectodomain Complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Butyrophilin subfamily 2 member A1, Butyrophilin subfamily 3 member A1 | 著者 | Fulford, T.S, Soliman, C, Castle, R.G, Rigau, M, Ruan, Z, Dolezal, O, Seneviratna, R, Brown, H.G, Hanssen, E, Hammet, A, Li, S, Redmond, S.J, Chung, A, Gorman, M.A, Parker, M.W, Patel, O, Peat, T.S, Newman, J, Behren, A, Gherardin, N.A, Godfrey, D.I, Uldrich, A.P. | 登録日 | 2022-06-22 | 公開日 | 2023-07-05 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (5.55 Å) | 主引用文献 | Vgamma9-Vdelta2 T cells recognize butyrophilin 2A1 and 3A1 heteromers To Be Published
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