3EYH
Crystal structures of JAK1 and JAK2 inhibitor complexes
Summary for 3EYH
Entry DOI | 10.2210/pdb3eyh/pdb |
Related | 3EYG |
Descriptor | Tyrosine-protein kinase, 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE (3 entities in total) |
Functional Keywords | jak kinase, atp-binding, kinase, nucleotide-binding, phosphoprotein, sh2 domain, transferase, tyrosine-protein kinase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 33798.55 |
Authors | Williams, N.K.,Bamert, R.S.,Patell, O.,Wang, C.,Walden, P.M.,Fantino, E. (deposition date: 2008-10-20, release date: 2009-02-03, Last modification date: 2023-12-27) |
Primary citation | Williams, N.K.,Bamert, R.S.,Patel, O.,Wang, C.,Walden, P.M.,Wilks, A.F.,Fantino, E.,Rossjohn, J.,Lucet, I.S. Dissecting specificity in the Janus kinases: the structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains. J.Mol.Biol., 387:219-232, 2009 Cited by PubMed: 19361440DOI: 10.1016/j.jmb.2009.01.041 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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