6W4Z
 
 | | Galectin-8N terminal domain in complex with Methyl 3-O-[3-O-benzyloxy]-malonyl-beta-D-galactopyranoside | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Galectin-8, ... | | 著者 | Patel, B, Kishor, C, Blanchard, H. | | 登録日 | 2020-03-12 | | 公開日 | 2020-09-02 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | | 主引用文献 | Rational Design and Synthesis of Methyl-beta-d-galactomalonyl Phenyl Esters as Potent Galectin-8 N Antagonists.
J.Med.Chem., 63, 2020
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2B0H
 | | Solution structure of VBS3 fragment of talin | | 分子名称: | Talin-1 | | 著者 | Gingras, A.R, Vogel, K.P, Steinhoff, H.J, Ziegler, W.H, Patel, B, Emsley, J, Critchley, D.R, Roberts, G.C, Barsukov, I.L. | | 登録日 | 2005-09-14 | | 公開日 | 2006-01-17 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural and Dynamic Characterization of a Vinculin Binding Site in the Talin Rod
Biochemistry, 45, 2006
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1U89
 | | Solution structure of VBS2 fragment of talin | | 分子名称: | Talin 1 | | 著者 | Fillingham, I, Gingras, A.R, Papagrigoriou, E, Patel, B, Emsley, J, Roberts, G.C.K, Critchley, D.R, Barsukov, I.L. | | 登録日 | 2004-08-05 | | 公開日 | 2005-01-18 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A vinculin binding domain from the talin rod unfolds to form a complex with the vinculin head.
Structure, 13, 2005
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1U6H
 | | Vinculin head (0-258) in complex with the talin vinculin binding site 2 (849-879) | | 分子名称: | Talin, Vinculin | | 著者 | Fillingham, I, Gingras, A.R, Papagrigoriou, E, Patel, B, Emsley, J, Roberts, G.C.K, Critchley, D.R, Barsukov, I.L. | | 登録日 | 2004-07-30 | | 公開日 | 2005-01-18 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | | 主引用文献 | A vinculin binding domain from the talin rod unfolds to form a complex with the vinculin head.
Structure, 13, 2005
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1ZK7
 | | Crystal Structure of Tn501 MerA | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Mercuric reductase, ... | | 著者 | Dong, A, Ledwidge, R, Patel, B, Fiedler, D, Falkowski, M, Zelikova, J, Summers, A.O, Pai, E.F, Miller, S.M. | | 登録日 | 2005-05-02 | | 公開日 | 2005-07-05 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | NmerA, the Metal Binding Domain of Mercuric Ion Reductase, Removes Hg(2+) from Proteins, Delivers It to the Catalytic Core, and Protects Cells under Glutathione-Depleted Conditions
Biochemistry, 44, 2005
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1ZX9
 | | Crystal Structure of Tn501 MerA | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Mercuric reductase | | 著者 | Dong, A, Ledwidge, R, Patel, B, Fiedler, D, Falkowski, M, Zelikova, J, Summers, A.O, Pai, E.F, Miller, S.M. | | 登録日 | 2005-06-07 | | 公開日 | 2005-07-05 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | NmerA, the Metal Binding Domain of Mercuric Ion Reductase, Removes Hg(2+) from Proteins, Delivers It to the Catalytic Core, and Protects Cells under Glutathione-Depleted Conditions
Biochemistry, 44, 2005
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3ZH8
 | | A novel small molecule aPKC inhibitor | | 分子名称: | (2S)-3-phenyl-N~1~-[2-(pyridin-4-yl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl]propane-1,2-diamine, 1,2-ETHANEDIOL, CHLORIDE ION, ... | | 著者 | Kjaer, S, Purkiss, A.G, Kostelecky, B, Knowles, P.P, Soriano, E, Murray-Rust, J, McDonald, N.Q. | | 登録日 | 2012-12-20 | | 公開日 | 2013-02-27 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.739 Å) | | 主引用文献 | Adenosine-Binding Motif Mimicry and Cellular Effects of a Thieno[2,3-D]Pyrimidine-Based Chemical Inhibitor of Atypical Protein Kinase C Isozymes.
Biochem.J., 451, 2013
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7UFV
 | | Crystal structure of the WDR domain of human DCAF1 in complex with OICR-6766 | | 分子名称: | (3P)-N-[(1S)-3-amino-1-(3-chlorophenyl)-3-oxopropyl]-3-(2-fluorophenyl)-1H-pyrazole-4-carboxamide, DDB1- and CUL4-associated factor 1, UNKNOWN ATOM OR ION | | 著者 | Kimani, S, Li, A, Li, Y, Dong, A, Hutchinson, A, Seitova, A, Wilson, B, Al-Awar, R, Vedadi, M, Brown, P, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | | 登録日 | 2022-03-23 | | 公開日 | 2022-05-04 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Discovery of Nanomolar DCAF1 Small Molecule Ligands.
J.Med.Chem., 66, 2023
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1T01
 | | Vinculin complexed with the VBS1 helix from talin | | 分子名称: | Talin 1, unnamed protein product | | 著者 | Papagrigoriou, E, Gingras, A.R, Barsukov, I.L, Critchley, D.R, Emsley, J. | | 登録日 | 2004-04-07 | | 公開日 | 2004-08-24 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle
Embo J., 23, 2004
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1XWJ
 | | Vinculin head (1-258) in complex with the talin vinculin binding site 3 (1945-1969) | | 分子名称: | Talin, Vinculin | | 著者 | Gingras, A.R, Papagrigoriou, E, Barsukov, I.L, Critchley, D.R, Emsley, J. | | 登録日 | 2004-11-01 | | 公開日 | 2005-10-11 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural and Dynamic Characterization of a Vinculin Binding Site in the Talin Rod
Biochemistry, 45, 2006
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1SJ7
 | | Crystal Structure of Talin Rod 482-655 | | 分子名称: | PLATINUM (II) ION, Talin 1 | | 著者 | Papagrigoriou, E, Gingras, A.R, Barsukov, I.L, Critchley, D.R, Emsley, J. | | 登録日 | 2004-03-03 | | 公開日 | 2004-08-24 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle
EMBO J., 23, 2004
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1SJ8
 | | Solution Structure of the R1R2 Domains of Talin | | 分子名称: | Talin 1 | | 著者 | Papagrigoriou, E, Gingras, A.R, Barsukov, I.L, Critchley, D.R, Emsley, J. | | 登録日 | 2004-03-03 | | 公開日 | 2004-08-24 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle
EMBO J., 23, 2004
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2X0C
 | | Crystal Structure of the R7R8 domains of Talin | | 分子名称: | TALIN-1 | | 著者 | Gingras, A.R, Goult, B.T, Bate, N, Barsukov, I.L, Emsley, J, Critchely, D.R. | | 登録日 | 2009-12-08 | | 公開日 | 2010-07-07 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Central Region of Talin Has a Unique Fold that Binds Vinculin and Actin.
J.Biol.Chem., 285, 2010
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2KBB
 | | Solution Structure of the R9 Domain of Talin | | 分子名称: | Talin-1 | | 著者 | Goult, B.T, Gingras, A.R, Bate, N, Critchley, D.R, Barsukov, I.L. | | 登録日 | 2008-11-24 | | 公開日 | 2009-03-17 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The structure of an interdomain complex that regulates talin activity.
J.Biol.Chem., 284, 2009
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2KC2
 | | NMR structure of the F1 domain (residues 86-202) of the talin | | 分子名称: | Talin-1 | | 著者 | Goult, B.T, Elliott, P.R, Roberts, G.C.K, Critchely, D.R, Barsukov, I.L. | | 登録日 | 2008-12-13 | | 公開日 | 2010-01-19 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation.
Embo J., 29, 2010
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2KGX
 | | HADDOCK structure of the talin F3 domain in complex with talin 1655-1822 | | 分子名称: | MKIAA1027 protein, Talin-1 | | 著者 | Goult, B.T, Gingras, A.R, Bate, N, Critchley, D.R, Barsukov, I.L. | | 登録日 | 2009-03-23 | | 公開日 | 2009-03-31 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The structure of an interdomain complex that regulates talin activity.
J.Biol.Chem., 284, 2009
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2KMC
 | | Solution Structure of the N-terminal domain of kindlin-1 | | 分子名称: | Fermitin family homolog 1 | | 著者 | Goult, B.T, Bate, N, Roberts, G.C, Barsukov, I.L, Critchley, D.R. | | 登録日 | 2009-07-27 | | 公開日 | 2009-10-06 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The Structure of the N-Terminus of Kindlin-1: A Domain Important for alphaIIbbeta3 Integrin Activation
J.Mol.Biol., 394, 2009
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2KC1
 | | NMR structure of the F0 domain (residues 0-85) of the talin ferm domain | | 分子名称: | MKIAA1027 protein | | 著者 | Goult, B.T, Elliott, P.R, Roberts, G.C.K, Critchley, D.R, Barsukov, I.L. | | 登録日 | 2008-12-13 | | 公開日 | 2010-01-19 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation.
Embo J., 29, 2010
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2KMA
 | | NMR structure of the F0F1 double domain (residues 1-202) of the talin ferm domain | | 分子名称: | Talin 1 | | 著者 | Goult, B.T, Elliott, P.R, Bate, N, Roberts, G.C, Critchley, D.R, Barsukov, I.L. | | 登録日 | 2009-07-25 | | 公開日 | 2010-03-02 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation.
Embo J., 2010
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2KT2
 | | Structure of NmerA, the N-terminal HMA domain of Tn501 Mercuric Reductase | | 分子名称: | Mercuric reductase | | 著者 | Ledwidge, R, Danacea, F, Dotsch, V, Miller, S.M. | | 登録日 | 2010-01-17 | | 公開日 | 2010-09-22 | | 最終更新日 | 2024-05-08 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NmerA of Tn501 mercuric ion reductase: structural modulation of the pKa values of the metal binding cysteine thiols.
Biochemistry, 49, 2010
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2KT3
 | | Structure of Hg-NmerA, Hg(II) complex of the N-terminal domain of Tn501 Mercuric Reductase | | 分子名称: | MERCURY (II) ION, Mercuric reductase | | 著者 | Miller, S.M, Ledwidge, R, Danacea, F, Dotsch, V. | | 登録日 | 2010-01-17 | | 公開日 | 2010-09-22 | | 最終更新日 | 2024-05-08 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NmerA of Tn501 mercuric ion reductase: structural modulation of the pKa values of the metal binding cysteine thiols.
Biochemistry, 49, 2010
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3DYJ
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