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BU of 6i8a by Molmil

The crystal structure of the Pol2 catalytic domain of DNA polymerase epsilon carrying a P301R substitution.
分子名称:	2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ...
著者	Parkash, V, Johansson, E.
登録日	2018-11-19
公開日	2019-01-30
最終更新日	2024-01-24
実験手法	X-RAY DIFFRACTION (2.652 Å)
主引用文献	Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase epsilon. Nat Commun, 10, 2019

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BU of 3fub by Molmil

Crystal structure of GDNF-GFRalpha1 complex
分子名称:	1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者	Parkash, V, Goldman, A.
登録日	2009-01-14
公開日	2009-06-02
最終更新日	2024-10-30
実験手法	X-RAY DIFFRACTION (2.35 Å)
主引用文献	Comparison of GFL-GFRalpha complexes: further evidence relating GFL bend angle to RET signalling Acta Crystallogr.,Sect.F, 65, 2009

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BU of 6fwk by Molmil

The crystal structure of Pol2CORE-M644G in complex with DNA and an incoming nucleotide
分子名称:	2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(PTPAPAPCPCPGPCPGPTPTP*(DOC))-3'), ...
著者	Parkash, V, Johansson, E.
登録日	2018-03-06
公開日	2019-01-30
最終更新日	2024-05-08
実験手法	X-RAY DIFFRACTION (2.503 Å)
主引用文献	Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase epsilon. Nat Commun, 10, 2019

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BU of 6g0a by Molmil

The crystal structure of the Pol2 catalytic domain of DNA polymerase epsilon carrying a P301R substitution.
分子名称:	2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(PTPAPAPCPCPGPCPGPTPTP*DC)-3'), ...
著者	Parkash, V, Johansson, E.
登録日	2018-03-16
公開日	2019-01-30
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (2.62 Å)
主引用文献	Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase epsilon. Nat Commun, 10, 2019

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BU of 2v5e by Molmil

The structure of the GDNF:Coreceptor complex: Insights into RET signalling and heparin binding.
分子名称:	1,2-ETHANEDIOL, 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者	Parkash, V, Leppanen, V.-M, Virtanen, H, Jurvansuu, J.-M, Bespalov, M.M, Sidorova, Y.A, Runeberg-Roos, P, Saarma, M, Goldman, A.
登録日	2008-10-03
公開日	2008-10-21
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (2.35 Å)
主引用文献	The Structure of the Glial Cell Line-Derived Neurotrophic Factor-Coreceptor Complex: Insights Into Ret Signaling and Heparin Binding. J.Biol.Chem., 283, 2008

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BU of 2w50 by Molmil

N-terminal domain of human conserved dopamine neurotrophic factor (CDNF)
分子名称:	ARMET-LIKE PROTEIN 1, PHOSPHATE ION
著者	Parkash, V, Lindholm, P, Peranen, J, Kalkkinen, N, Oksanen, E, Saarma, M, Leppanen, V.M, Goldman, A.
登録日	2008-12-03
公開日	2009-03-17
最終更新日	2019-05-08
実験手法	X-RAY DIFFRACTION (1.6 Å)
主引用文献	The Structure of the Conserved Neurotrophic Factors Manf and Cdnf Explains Why They are Bifunctional. Protein Eng.Des.Sel., 22, 2009

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BU of 2w51 by Molmil

Human mesencephalic astrocyte-derived neurotrophic factor (MANF)
分子名称:	PROTEIN ARMET
著者	Parkash, V, Lindholm, P, Peranen, J, Kalkkinen, N, Oksanen, E, Saarma, M, Leppanen, V.M, Goldman, A.
登録日	2008-12-03
公開日	2009-03-17
最終更新日	2024-05-01
実験手法	X-RAY DIFFRACTION (2.8 Å)
主引用文献	The Structure of the Conserved Neurotrophic Factors Manf and Cdnf Explains Why They are Bifunctional. Protein Eng.Des.Sel., 22, 2009

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BU of 8b67 by Molmil

The crystal structure of M644G variant of DNA Pol Epsilon containing CTP in the polymerase active site
分子名称:	ACETATE ION, CALCIUM ION, CYTIDINE-5'-TRIPHOSPHATE, ...
著者	Parkash, V, Johansson, E.
登録日	2022-09-26
公開日	2023-10-25
最終更新日	2023-11-01
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides. Nucleic Acids Res., 2023

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BU of 8b6k by Molmil

The crystal structure of M644G variant of DNA Pol Epsilon containing dCTP in the polymerase active site
分子名称:	2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ...
著者	Parkash, V, Johansson, E.
登録日	2022-09-27
公開日	2023-10-25
最終更新日	2023-11-01
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides. Nucleic Acids Res., 2023

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BU of 8b7e by Molmil

The crystal structure of N828V variant of DNA Pol Epsilon containing UTP in the polymerase active site
分子名称:	CALCIUM ION, DNA polymerase epsilon catalytic subunit A, GLYCEROL, ...
著者	Parkash, V, Johansson, E.
登録日	2022-09-29
公開日	2023-10-25
最終更新日	2023-11-01
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides. Nucleic Acids Res., 2023

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BU of 8b79 by Molmil

The crystal structure of M644G variant of DNA Pol Epsilon containing UTP in the polymerase active site
分子名称:	ACETATE ION, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ...
著者	Parkash, V, Johansson, E.
登録日	2022-09-29
公開日	2023-10-25
最終更新日	2023-11-01
実験手法	X-RAY DIFFRACTION (2.65 Å)
主引用文献	A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides. Nucleic Acids Res., 2023

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BU of 8b77 by Molmil

The crystal structure of N828V variant of DNA Pol Epsilon containing dATP in the polymerase active site
分子名称:	2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ...
著者	Parkash, V, Johansson, E.
登録日	2022-09-29
公開日	2023-10-25
最終更新日	2023-11-01
実験手法	X-RAY DIFFRACTION (2.7 Å)
主引用文献	A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides. Nucleic Acids Res., 2023

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BU of 8b76 by Molmil

The crystal structure of M644G variant of DNA Pol Epsilon containing dTTP in the polymerase active site
分子名称:	ACETATE ION, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ...
著者	Parkash, V, Johansson, E.
登録日	2022-09-28
公開日	2023-11-01
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides. Nucleic Acids Res., 2023

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BU of 6qib by Molmil

The crystal structure of Pol2CORE in complex with DNA and an incoming nucleotide, carrying an Fe-S cluster
分子名称:	2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ...
著者	Parkash, V, Johansson, E.
登録日	2019-01-18
公開日	2019-04-17
最終更新日	2024-01-24
実験手法	X-RAY DIFFRACTION (2.8 Å)
主引用文献	Structural evidence for an essential Fe-S cluster in the catalytic core domain of DNA polymerase ε. Nucleic Acids Res., 47, 2019

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BU of 6h1v by Molmil

The crystal structure of Pol2CORE in complex with DNA and an incoming nucleotide, carrying an Fe-S cluster
分子名称:	2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(PAPAPTPTPGPAPAPCPGPCPGPGPTPTPA)-3'), DNA (5'-D(PTPAPAPCPCPGPCPGPTPTP(DOC))-3'), ...
著者	Parkash, V, Johansson, E.
登録日	2018-07-12
公開日	2019-04-24
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (2.7 Å)
主引用文献	Structural evidence for an essential Fe-S cluster in the catalytic core domain of DNA polymerase ε. Nucleic Acids Res., 47, 2019

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BU of 4a0q by Molmil

Activated Conformation of Integrin alpha1 I-Domain mutant
分子名称:	INTEGRIN ALPHA-1, MAGNESIUM ION
著者	Lahti, M, Bligt, E, Niskanen, H, Parkash, V, Brandt, A.-M, Jokinen, J, Patrikainen, P, Kapyla, J, Heino, J, Salminen, T.A.
登録日	2011-09-12
公開日	2011-10-26
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Structure of Collagen Receptor Integrin Aplha1I Domain Carrying the Activating Mutation E317A. J.Biol.Chem., 286, 2011

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BU of 2y73 by Molmil

THE NATIVE STRUCTURES OF SOLUBLE HUMAN PRIMARY AMINE OXIDASE AOC3
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者	Elovaara, H, Kidron, H, Parkash, V, Nymalm, Y, Bligt, E, Ollikka, P, Smith, D.J, Pihlavisto, M, Salmi, M, Jalkanen, S, Salminen, T.A.
登録日	2011-01-28
公開日	2011-06-15
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	Identification of Two Imidazole Binding Sites and Key Residues for Substrate Specificity in Human Primary Amine Oxidase Aoc3. Biochemistry, 50, 2011

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BU of 7r3x by Molmil

The crystal structure of the L439V variant of Pol2CORE in complex with DNA and an incoming nucleotide
分子名称:	2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, ACETATE ION, CALCIUM ION, ...
著者	Barbari, S.R, Beach, A.K, Markgren, J.G, Parkash, V, Johansson, E, Shcherbakova, P.V.
登録日	2022-02-08
公開日	2022-07-27
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (2.46 Å)
主引用文献	Enhanced polymerase activity permits efficient synthesis by cancer-associated DNA polymerase ε variants at low dNTP levels. Nucleic Acids Res., 50, 2022

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BU of 7r3y by Molmil

The crystal structure of the V426L variant of Pol2CORE in complex with DNA and an incoming nucleotide
分子名称:	2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA Primer, ...
著者	Barbari, S.R, Beach, A.K, Markgren, J.G, Parkash, V, Johansson, E, Shcherbakova, P.V.
登録日	2022-02-08
公開日	2022-07-27
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	Enhanced polymerase activity permits efficient synthesis by cancer-associated DNA polymerase ε variants at low dNTP levels. Nucleic Acids Res., 50, 2022

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BU of 2y74 by Molmil

THE CRYSTAL STRUCTURE OF HUMAN SOLUBLE PRIMARY AMINE OXIDASE AOC3 IN THE OFF-COPPER CONFORMATION
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者	Elovaara, H, Kidron, H, Parkash, V, Nymalm, Y, Bligt, E, Ollikka, P, Smith, D.J, Pihlavisto, M, Salmi, M, Jalkanen, S, Salminen, T.A.
登録日	2011-01-28
公開日	2011-06-15
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (2.95 Å)
主引用文献	Identification of Two Imidazole Binding Sites and Key Residues for Substrate Specificity in Human Primary Amine Oxidase Aoc3. Biochemistry, 50, 2011

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