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5FIU
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Binding and structural studies of a 5,5-difluoromethyl adenosine nucleoside with the fluorinase enzyme
分子名称: 5'-FLUORO-5'-DEOXY-ADENOSINE SYNTHASE, 5,5-DIFLUOROMETHYL ADENOSINE, L(+)-TARTARIC ACID
著者Thompson, S, McMahon, S.A, Naismith, J.H, O'Hagan, D.
登録日2015-10-02
公開日2015-12-23
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Exploration of a Potential Difluoromethyl-Nucleoside Substrate with the Fluorinase Enzyme.
Bioorg.Chem., 64, 2015
1RQP
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Crystal structure and mechanism of a bacterial fluorinating enzyme
分子名称: 5'-fluoro-5'-deoxyadenosine synthase, S-ADENOSYLMETHIONINE
著者Dong, C, Huang, F, Deng, H, Schaffrath, C, Spencer, J.B, O'Hagan, D, Naismith, J.H.
登録日2003-12-06
公開日2004-03-02
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure and mechanism of a bacterial fluorinating enzyme
Nature, 427, 2004
1RQR
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Crystal structure and mechanism of a bacterial fluorinating enzyme, product complex
分子名称: 5'-FLUORO-5'-DEOXYADENOSINE, 5'-fluoro-5'-deoxyadenosine synthase, METHIONINE
著者Dong, C, Huang, F, Deng, H, Schaffrath, C, Spencer, J.B, O'Hagan, D, Naismith, J.H.
登録日2003-12-07
公開日2004-03-02
最終更新日2022-06-15
実験手法X-RAY DIFFRACTION (2.67 Å)
主引用文献Crystal structure and mechanism of a bacterial fluorinating enzyme
Nature, 427, 2004
5LMZ
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Fluorinase from Streptomyces sp. MA37
分子名称: 1-DEAZA-ADENOSINE, CHLORIDE ION, Fluorinase, ...
著者Mann, G, O'Hagan, D, Naismith, J.H, Bandaranayaka, N.
登録日2016-08-02
公開日2016-08-24
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Identification of fluorinases from Streptomyces sp MA37, Norcardia brasiliensis, and Actinoplanes sp N902-109 by genome mining.
Chembiochem, 15, 2014
2WR8
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BU of 2wr8 by Molmil
Structure of Pyrococcus horikoshii SAM hydroxide adenosyltransferase in complex with SAH
分子名称: PUTATIVE UNCHARACTERIZED PROTEIN PH0463, S-ADENOSYL-L-HOMOCYSTEINE
著者McMahon, S.A, Deng, H, O'Hagan, D, Johnson, K.A, Naismith, J.H.
登録日2009-08-31
公開日2009-09-22
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Mechanistic Insights Into Water Activation in Sam Hydroxide Adenosyltransferase (Duf-62).
Chembiochem, 10, 2009
3LCC
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Structure of a SAM-dependent halide methyltransferase from Arabidopsis thaliana
分子名称: CHLORIDE ION, Putative methyl chloride transferase, S-ADENOSYL-L-HOMOCYSTEINE
著者Schmidberger, J.W, O'Hagan, D, Naismith, J.H.
登録日2010-01-10
公開日2010-05-19
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Halomethane Biosynthesis: Structure of a SAM-Dependent Halide Methyltransferase from Arabidopsis thaliana
Angew.Chem.Int.Ed.Engl., 49, 2010
2CBX
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BU of 2cbx by Molmil
X-ray crystal structure of 5'-fluorodeoxyadenosine synthase from Streptomyces cattleya complexed with beta-D-erythrofuranosyl- adenosine
分子名称: 5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE, BETA-D-ERYTHROFURANOSYL-ADENOSINE, GLYCEROL
著者McEwan, A.R, Cadicamo, C.D, Deng, H, McGlinchey, R.P, Robinson, D.R, O'Hagan, D, Naismith, J.H, Spencer, J.
登録日2006-01-09
公開日2007-03-06
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Substrate specificity in enzymatic fluorination. The fluorinase from Streptomyces cattleya accepts 2'-deoxyadenosine substrates.
Org. Biomol. Chem., 4, 2006
4CQJ
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Fluorinase substrate flexibility enables last step aqueous and ambient 18F fluorination of a RGD peptide for positron emission tomography
分子名称: 5'-FLUORO-5'-DEOXY-ADENOSINE SYNTHASE, 5'-deoxy-2-ethynyl-5'-fluoroadenosine
著者McMahon, S.A, Thompson, S, O'Hagan, D, Naismith, J.H.
登録日2014-02-17
公開日2014-05-28
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.44 Å)
主引用文献Structure of a Bacterial Fluorinating Enzyme with
To be Published
2C4U
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Crystal structure of the apo form of the 5'-Fluoro-5'-deoxyadenosine synthase enzyme from Streptomyces cattleya
分子名称: 5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE, GLYCEROL
著者McEwan, A.R, Deng, H, Robinson, D.A, DeLaurentis, W, McGlinchey, R.P, O'Hagan, D, Naismith, J.H.
登録日2005-10-22
公開日2006-04-12
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Substrate specificity in enzymatic fluorination. The fluorinase from Streptomyces cattleya accepts 2'-deoxyadenosine substrates.
Org. Biomol. Chem., 4, 2006
2C4T
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X-ray crystal structure of 5'-fluorodeoxyadenosine synthase from Streptomyces cattleya complexed with an inhibitor, an analogue of S- adenosyl methionine
分子名称: 5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE, CHLORIDE ION, S-5'-AZAMETHIONINE-5'-DEOXYADENOSINE
著者McEwan, A.R, Deng, H, McGlinchey, R.P, Robinson, D.R, O'Hagan, D, Naismith, J.H.
登録日2005-10-22
公開日2007-03-27
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Substrates and Inhibitors of the Fluorinase from Streptomyces Cattleya
To be Published
2C2W
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The fluorinase from Streptomyces cattleya is also a chlorinase. Structure of 5'-chloro-5'-deoxyadenosine crystallised in the fluorinase.
分子名称: 5'-CHLORO-5'-DEOXYADENOSINE, 5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE, CHLORIDE ION
著者McEwan, A.R, Naismith, J.H, O'Hagan, D.
登録日2005-09-30
公開日2005-12-19
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The fluorinase from Streptomyces cattleya is also a chlorinase.
Angew. Chem. Int. Ed. Engl., 45, 2006
2V7X
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X-RAY CRYSTAL STRUCTURE OF 5'-FLUORODEOXYADENOSINE SYNTHASE S158A mutant FROM STREPTOMYCES CATTLEYA COMPLEXED WITH the PRODUCTS, FDA and Met
分子名称: 5'-FLUORO-5'-DEOXYADENOSINE, 5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE, METHIONINE
著者Robinson, D.A, Zhu, X, O'Hagan, D, Naismith, J.H.
登録日2007-08-02
公開日2008-08-12
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Mechanism of enzymatic fluorination in Streptomyces cattleya.
J. Am. Chem. Soc., 129, 2007
2V7V
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X-ray crystal structure of 5'-fluorodeoxyadenosine synthase from streptomyces cattleya complexed with 5'-fluorodeoxyadenosine
分子名称: 5'-FLUORO-5'-DEOXYADENOSINE, 5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE
著者Zhu, X, O'Hagan, D, Naismith, J.H.
登録日2007-08-02
公開日2008-08-12
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Mechanism of enzymatic fluorination in Streptomyces cattleya.
J. Am. Chem. Soc., 129, 2007
2V7W
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X-ray crystal structure of 5'-fluorodeoxyadenosine synthase s158g mutant complexed with 5'-fluorodeoxyadenosin
分子名称: 5'-FLUORO-5'-DEOXYADENOSINE, 5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE
著者Zhu, X, O'Hagan, D, Naismith, J.H.
登録日2007-08-02
公開日2008-08-12
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Mechanism of enzymatic fluorination in Streptomyces cattleya.
J. Am. Chem. Soc., 129, 2007
2V7T
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X-ray crystal structure of 5'-fluorodeoxyadenosine synthase s158g mutant complexed with s-adenosyl-l-homocysteine and chloride ion
分子名称: 5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE, CHLORIDE ION, S-ADENOSYL-L-HOMOCYSTEINE
著者Zhu, X, O'Hagan, D, Naismith, J.H.
登録日2007-08-01
公開日2008-08-12
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Mechanism of enzymatic fluorination in Streptomyces cattleya.
J. Am. Chem. Soc., 129, 2007
2V7U
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X-ray crystal structure of 5'-fluorodeoxyadenosine synthase s158g mutant complexed with s-adenosylmethionine and chloride ion
分子名称: 5'-FLUORO-5'-DEOXY ADENOSINE SYNTHETASE, CHLORIDE ION, S-ADENOSYLMETHIONINE
著者Zhu, X, O'Hagan, D, Naismith, J.H.
登録日2007-08-02
公開日2008-08-12
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Mechanism of enzymatic fluorination in Streptomyces cattleya.
J. Am. Chem. Soc., 129, 2007
2C5B
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X-ray crystal structure of 5'-fluorodeoxyadenosine synthase from Streptomyces cattleya complexed with 2'deoxy-5'deoxy-fluoroadenosine.
分子名称: 5'-FLUORO-2',5'-DIDEOXYADENOSINE, 5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE, METHIONINE
著者McEwan, A.R, Deng, H, McGlinchey, R.P, Robinson, D.A, O'Hagan, D, Naismith, J.H, Spencer, J.
登録日2005-10-26
公開日2007-02-20
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Substrate Specificity in Enzymatic Fluorination. The Fluorinase from Streptomyces Cattleya Accepts 2'-Deoxyadenosine Substrates.
Org.Biomol.Chem., 4, 2006
2C5H
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BU of 2c5h by Molmil
X-ray crystal structure of 5'-fluorodeoxyadenosine synthase from Streptomyces cattleya complexed with 2'deoxy-adenosine
分子名称: (2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-tetrahydro-2-(hydroxymethyl)furan-3-ol, 5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE, CHLORIDE ION, ...
著者McEwan, A.R, Deng, H, McGlinchey, R.P, Robinson, D.R, O'Hagan, D, Naismith, J.H, Spencer, J.
登録日2005-10-27
公開日2006-10-25
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Substrates and Inhibitors of the Fluorinase from Streptomyces Cattleya
To be Published
2CC2
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X-ray crystal structure of 5'-fluorodeoxyadenosine synthase from Streptomyces cattleya complexed with 5'deoxyadenosine
分子名称: 5'-DEOXYADENOSINE, 5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE, CHLORIDE ION
著者Mcewan, A.R, Deng, H, McGlinchey, R.P, Robinson, D.R, O'Hagan, D, Spencer, J, Naismith, J.H.
登録日2006-01-11
公開日2007-03-20
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Substrate specificity in enzymatic fluorination. The fluorinase from Streptomyces cattleya accepts 2'-deoxyadenosine substrates.
Org. Biomol. Chem., 4, 2006
3NYP
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A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine ligand containing bis-3-fluoropyrrolidine end side chains
分子名称: 3,6-bis(3-(3'-(R)-fluoropyrrolindino)propionamido)acridine, 5'-D(*GP*GP*GP*GP*TP*TP*TP*TP*GP*GP*GP*G)-3', POTASSIUM ION
著者Campbell, N.H, Neidle, S.
登録日2010-07-15
公開日2010-08-25
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.179 Å)
主引用文献Fluorine in medicinal chemistry: beta-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNA.
Org.Biomol.Chem., 9, 2011
3NZ7
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A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine ligand containing bis-3-fluoropyrrolidine end side chains
分子名称: 3,6-bis(3-(3'-(S)-fluoropyrrolindino)propionamido)acridine, 5'-D(*GP*GP*GP*GP*TP*TP*TP*TP*GP*GP*GP*G)-3', POTASSIUM ION
著者Campbell, N.H, Neidle, S.
登録日2010-07-16
公開日2010-08-25
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Fluorine in medicinal chemistry: beta-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNA.
Org.Biomol.Chem., 9, 2011

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