3IGQ
| |
2C3E
| The bovine mitochondrial ADP-ATP carrier | 分子名称: | ADP/ATP TRANSLOCASE 1, CARDIOLIPIN, Carboxyatractyloside | 著者 | Nury, H, Dahout-Gonzalez, C, Trezeguet, V, Lauquin, G, Brandolin, G, Pebay-Peyroula, E. | 登録日 | 2005-10-06 | 公開日 | 2005-10-20 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural Basis for Lipid-Mediated Interactions between Mitochondrial Adp/ATP Carrier Monomers. FEBS Lett., 579, 2005
|
|
3LSV
| |
3P50
| Structure of propofol bound to a pentameric ligand-gated ion channel, GLIC | 分子名称: | 2,6-BIS(1-METHYLETHYL)PHENOL, DIUNDECYL PHOSPHATIDYL CHOLINE, DODECYL-BETA-D-MALTOSIDE, ... | 著者 | Nury, H, Van Renterghem, C, Weng, Y, Tran, A, Baaden, M, Dufresne, V, Changeux, J.P, Sonner, J.M, Delarue, M, Corringer, P.J. | 登録日 | 2010-10-07 | 公開日 | 2011-01-19 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel Nature, 469, 2011
|
|
3P4W
| Structure of desflurane bound to a pentameric ligand-gated ion channel, GLIC | 分子名称: | (2S)-2-(difluoromethoxy)-1,1,1,2-tetrafluoroethane, DIUNDECYL PHOSPHATIDYL CHOLINE, DODECYL-BETA-D-MALTOSIDE, ... | 著者 | Nury, H, Van Renterghem, C, Weng, Y, Tran, A, Baaden, M, Dufresne, V, Changeux, J.P, Sonner, J.M, Delarue, M, Corringer, P.J. | 登録日 | 2010-10-07 | 公開日 | 2011-01-19 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel Nature, 469, 2011
|
|
6HK0
| X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) F16'S pore mutant (F247S) with alternate M4 conformation. | 分子名称: | Cys-loop ligand-gated ion channel, DODECYL-BETA-D-MALTOSIDE | 著者 | Nury, H, Spurny, R, Govaerts, C, Evans, G.L, Pardon, E, Steyaert, J, Ulens, C. | 登録日 | 2018-09-04 | 公開日 | 2019-10-09 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.45 Å) | 主引用文献 | A lipid site shapes the agonist response of a pentameric ligand-gated ion channel. Nat.Chem.Biol., 15, 2019
|
|
7Z14
| Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with a short-chain neurotoxin. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholine receptor subunit alpha, ... | 著者 | Nys, M.A.E.M, Zarkadas, E, Ulens, C, Nury, H. | 登録日 | 2022-02-24 | 公開日 | 2022-08-17 | 最終更新日 | 2022-08-24 | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | 主引用文献 | The molecular mechanism of snake short-chain alpha-neurotoxin binding to muscle-type nicotinic acetylcholine receptors. Nat Commun, 13, 2022
|
|
4PIR
| X-ray structure of the mouse serotonin 5-HT3 receptor | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, ... | 著者 | Hassaine, G, Deluz, C, Grasso, L, Wyss, R, Tol, M.B, Hovius, R, Graff, A, Stahlberg, H, Tomizaki, T, Desmyter, A, Moreau, C, Li, X.-D, Poitevin, F, Vogel, H, Nury, H. | 登録日 | 2014-05-09 | 公開日 | 2014-08-06 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | X-ray structure of the mouse serotonin 5-HT3 receptor. Nature, 512, 2014
|
|
3TLS
| The GLIC pentameric Ligand-Gated Ion Channel E19'P mutant in a locally-closed conformation (LC2 subtype) | 分子名称: | CHLORIDE ION, DODECYL-BETA-D-MALTOSIDE, Glr4197 protein | 著者 | Sauguet, L, Nury, H, Corringer, P.J, Delarue, M. | 登録日 | 2011-08-30 | 公開日 | 2012-05-16 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | A locally closed conformation of a bacterial pentameric proton-gated ion channel. Nat.Struct.Mol.Biol., 19, 2012
|
|
3TLT
| The GLIC pentameric Ligand-Gated Ion Channel H11'F mutant in a locally-closed conformation (LC1 subtype) | 分子名称: | CHLORIDE ION, DODECYL-BETA-D-MALTOSIDE, Glr4197 protein | 著者 | Sauguet, L, Nury, H, Corringer, P.J, Delarue, M. | 登録日 | 2011-08-30 | 公開日 | 2012-05-16 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | A locally closed conformation of a bacterial pentameric proton-gated ion channel. Nat.Struct.Mol.Biol., 19, 2012
|
|
3TLV
| The GLIC pentameric Ligand-Gated Ion Channel Loop2-22' oxidized mutant in a locally-closed conformation (LC3 subtype) | 分子名称: | CHLORIDE ION, DODECYL-BETA-D-MALTOSIDE, Glr4197 protein | 著者 | Sauguet, L, Nury, H, Corringer, P.J, Delarue, M. | 登録日 | 2011-08-30 | 公開日 | 2012-05-16 | 最終更新日 | 2012-06-27 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | A locally closed conformation of a bacterial pentameric proton-gated ion channel. Nat.Struct.Mol.Biol., 19, 2012
|
|
3UUB
| The GLIC pentameric Ligand-Gated Ion Channel Loop2-21' mutant reduced in solution | 分子名称: | CHLORIDE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, DODECYL-BETA-D-MALTOSIDE, ... | 著者 | Sauguet, L, Nury, H, Corringer, P.J, Delarue, M. | 登録日 | 2011-11-28 | 公開日 | 2012-05-16 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | A locally closed conformation of a bacterial pentameric proton-gated ion channel. Nat.Struct.Mol.Biol., 19, 2012
|
|
8BL8
| Human serotonin 5-HT3A receptor (apo, active/distorted conformation) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A | 著者 | Lopez-Sanchez, U, Nury, H. | 登録日 | 2022-11-09 | 公開日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | 主引用文献 | Structural determinants for activity of the antidepressant vortioxetine at human and rodent 5-HT 3 receptors. Nat.Struct.Mol.Biol., 2024
|
|
8BLA
| |
8BLB
| |
8CC7
| Mouse serotonin 5-HT3A receptor in complex with PZ-1939 | 分子名称: | 1-(3-chlorophenyl)sulfonyl-4-piperazin-1-yl-pyrrolo[3,2-c]quinoline, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Lopez-Sanchez, U, Nury, H. | 登録日 | 2023-01-26 | 公開日 | 2023-10-11 | 最終更新日 | 2023-11-22 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Superiority of the Triple-Acting 5-HT 6 R/5-HT 3 R Antagonist and MAO-B Reversible Inhibitor PZ-1922 over 5-HT 6 R Antagonist Intepirdine in Alleviation of Cognitive Deficits in Rats. J.Med.Chem., 66, 2023
|
|
8CC6
| Mouse serotonin 5-HT3A receptor in complex with PZ-1922 | 分子名称: | 1-[(3-chlorophenyl)methyl]-4-piperazin-1-yl-pyrrolo[3,2-c]quinoline, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Lopez-Sanchez, U, Nury, H. | 登録日 | 2023-01-26 | 公開日 | 2023-10-11 | 最終更新日 | 2023-11-22 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Superiority of the Triple-Acting 5-HT 6 R/5-HT 3 R Antagonist and MAO-B Reversible Inhibitor PZ-1922 over 5-HT 6 R Antagonist Intepirdine in Alleviation of Cognitive Deficits in Rats. J.Med.Chem., 66, 2023
|
|
8AW2
| Mouse serotonin 5-HT3A receptor in complex with vortioxetine | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, ... | 著者 | Lopez-Sanchez, U, Nury, H. | 登録日 | 2022-08-29 | 公開日 | 2024-03-06 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | 主引用文献 | Structural determinants for activity of the antidepressant vortioxetine at human and rodent 5-HT 3 receptors. Nat.Struct.Mol.Biol., 2024
|
|
8AXD
| Human serotonin 5-HT3A receptor (apo, resting conformation) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A | 著者 | Lopez-Sanchez, U, Nury, H. | 登録日 | 2022-08-31 | 公開日 | 2024-03-06 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | 主引用文献 | Structural determinants for activity of the antidepressant vortioxetine at human and rodent 5-HT 3 receptors. Nat.Struct.Mol.Biol., 2024
|
|
6Y1Z
| Mouse serotonin 5HT3 receptor in complex with palonosetron | 分子名称: | (3~{a}~{S})-2-[(3~{S})-1-azabicyclo[2.2.2]octan-3-yl]-3~{a},4,5,6-tetrahydro-3~{H}-benzo[de]isoquinolin-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zarkadas, E, Perot, J, Nury, H. | 登録日 | 2020-02-14 | 公開日 | 2020-03-04 | 最終更新日 | 2022-09-14 | 実験手法 | ELECTRON MICROSCOPY (2.82 Å) | 主引用文献 | The Binding of Palonosetron and Other Antiemetic Drugs to the Serotonin 5-HT3 Receptor. Structure, 28, 2020
|
|
7QKO
| Torpedo muscle-type nicotinic acetylcholine receptor - Resting conformation | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Acetylcholine receptor subunit alpha, Acetylcholine receptor subunit beta, ... | 著者 | Zarkadas, E, Pebay-Peyroula, E, Baenziger, J, Nury, H. | 登録日 | 2021-12-18 | 公開日 | 2022-02-09 | 最終更新日 | 2022-05-04 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Conformational transitions and ligand-binding to a muscle-type nicotinic acetylcholine receptor. Neuron, 110, 2022
|
|
7QL6
| Torpedo muscle-type nicotinic acetylcholine receptor - carbamylcholine-bound conformation | 分子名称: | 2-[(AMINOCARBONYL)OXY]-N,N,N-TRIMETHYLETHANAMINIUM, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zarkadas, E, Pebay-Peyroula, E, Baenziger, J, Nury, H. | 登録日 | 2021-12-19 | 公開日 | 2022-02-09 | 最終更新日 | 2022-05-04 | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | 主引用文献 | Conformational transitions and ligand-binding to a muscle-type nicotinic acetylcholine receptor. Neuron, 110, 2022
|
|
7QL5
| Torpedo muscle-type nicotinic acetylcholine receptor - nicotine-bound conformation | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zarkadas, E, Pebay-Peyroula, E, Baenziger, J, Nury, H. | 登録日 | 2021-12-19 | 公開日 | 2022-02-09 | 最終更新日 | 2022-05-04 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Conformational transitions and ligand-binding to a muscle-type nicotinic acetylcholine receptor. Neuron, 110, 2022
|
|
3EAM
| An open-pore structure of a bacterial pentameric ligand-gated ion channel | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, DODECYL-BETA-D-MALTOSIDE, Glr4197 protein | 著者 | Bocquet, N, Nury, H, Baaden, M, Le Poupon, C, Changeux, J.P, Delarue, M, Corringer, P.J. | 登録日 | 2008-08-26 | 公開日 | 2008-11-04 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation. Nature, 457, 2009
|
|
2YOE
| X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in complex with GABA and flurazepam | 分子名称: | CYS-LOOP LIGAND-GATED ION CHANNEL, Flurazepam, GAMMA-AMINO-BUTANOIC ACID | 著者 | Spurny, R, Brams, M, Nury, H, Legrand, P, Ulens, C. | 登録日 | 2012-10-23 | 公開日 | 2012-10-31 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | 主引用文献 | Pentameric Ligand-Gated Ion Channel Elic is Activated by Gaba and Modulated by Benzodiazepines. Proc.Natl.Acad.Sci.USA, 109, 2012
|
|