5TO3
 
 | | Crystal structure of thrombin mutant W215A/E217A fused to EGF456 of thrombomodulin via a 31-residue linker and bound to PPACK | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-mannopyranose-(1-4)-beta-D-mannopyranose-(1-4)-alpha-D-mannopyranose-(1-4)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ... | | 著者 | Barranco-Medina, S, Murphy, M, Pelc, L, Chen, Z, Di Cera, E, Pozzi, N. | | 登録日 | 2016-10-16 | | 公開日 | 2017-03-29 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | | 主引用文献 | Rational Design of Protein C Activators.
Sci Rep, 7, 2017
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2X4M
 | | Yersinia Pestis Plasminogen Activator Pla | | 分子名称: | (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, COAGULASE/FIBRINOLYSIN, SULFATE ION | | 著者 | Eren, E, Murphy, M, Goguen, J, van den Berg, B. | | 登録日 | 2010-02-05 | | 公開日 | 2010-07-28 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | An Active Site Water Network in the Plasminogen Activator Pla from Yersinia Pestis
Structure, 18, 2010
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2X55
 | | Yersinia Pestis Plasminogen Activator Pla (Native) | | 分子名称: | (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, COAGULASE/FIBRINOLYSIN, SULFATE ION | | 著者 | Eren, E, Murphy, M, Goguen, J, van den Berg, B. | | 登録日 | 2010-02-05 | | 公開日 | 2010-07-28 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | An Active Site Water Network in the Plasminogen Activator Pla from Yersinia Pestis
Structure, 18, 2010
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2X56
 | | Yersinia Pestis Plasminogen Activator Pla (Native) | | 分子名称: | (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, COAGULASE/FIBRINOLYSIN | | 著者 | Eren, E, Murphy, M, Goguen, J, van den Berg, B. | | 登録日 | 2010-02-05 | | 公開日 | 2010-07-28 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | An Active Site Water Network in the Plasminogen Activator Pla from Yersinia Pestis
Structure, 18, 2010
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3HJH
 | | A rigid N-terminal clamp restrains the motor domains of the bacterial transcription-repair coupling factor | | 分子名称: | COBALT (II) ION, Transcription-repair-coupling factor | | 著者 | Murphy, M, Gong, P, Ralto, K, Manelyte, L, Savery, N, Theis, K. | | 登録日 | 2009-05-21 | | 公開日 | 2009-10-20 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | An N-terminal clamp restrains the motor domains of the bacterial transcription-repair coupling factor Mfd.
Nucleic Acids Res., 37, 2009
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4E90
 | | Human phosphodiesterase 9 in complex with inhibitors | | 分子名称: | 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ... | | 著者 | Liu, S. | | 登録日 | 2012-03-20 | | 公開日 | 2013-02-27 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors.
J.Med.Chem., 55, 2012
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8UTK
 | | IL-23R minibinder - 23R-B04dslf02IB | | 分子名称: | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE, 23R-B04dslf02IB, ... | | 著者 | Bera, A.K, Berger, S.A, Kang, A, Baker, D. | | 登録日 | 2023-10-31 | | 公開日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Preclinical proof of principle for orally delivered Th17 antagonist miniproteins.
Cell, 2024
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7UNB
 | | Crystal structure of malaria transmission-blocking antigen Pfs48/45-6C variant in complex with human antibodies RUPA-117 and RUPA-47 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Gametocyte surface protein P45/48, RUPA-117 Fab heavy chain, ... | | 著者 | Hailemariam, S, McLeod, B, Julien, J.-P. | | 登録日 | 2022-04-10 | | 公開日 | 2022-08-10 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | | 主引用文献 | Vaccination with a structure-based stabilized version of malarial antigen Pfs48/45 elicits ultra-potent transmission-blocking antibody responses.
Immunity, 55, 2022
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7Y3L
 | | Structure of SALL3 ZFC4 bound with 12 bp AT-rich dsDNA | | 分子名称: | DNA (12-mer), Sal-like protein 3, ZINC ION | | 著者 | Ru, W, Xu, C. | | 登録日 | 2022-06-11 | | 公開日 | 2022-10-26 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural studies of SALL family protein zinc finger cluster domains in complex with DNA reveal preferential binding to an AATA tetranucleotide motif.
J.Biol.Chem., 298, 2022
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7Y3K
 | | Structure of SALL4 ZFC4 bound with 16 bp AT-rich dsDNA | | 分子名称: | DNA (16-mer), Sal-like protein 4, ZINC ION | | 著者 | Ru, W, Xu, C. | | 登録日 | 2022-06-11 | | 公開日 | 2022-10-26 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.501 Å) | | 主引用文献 | Structural studies of SALL family protein zinc finger cluster domains in complex with DNA reveal preferential binding to an AATA tetranucleotide motif.
J.Biol.Chem., 298, 2022
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7Y3I
 | | Structure of DNA bound SALL4 | | 分子名称: | DNA (12-mer), Sal-like protein 4, ZINC ION | | 著者 | Ru, W, Xu, C. | | 登録日 | 2022-06-10 | | 公開日 | 2022-10-26 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Structural studies of SALL family protein zinc finger cluster domains in complex with DNA reveal preferential binding to an AATA tetranucleotide motif.
J.Biol.Chem., 298, 2022
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7Y3M
 | | Structure of SALL4 ZFC1 bound with 16 bp AT-rich dsDNA | | 分子名称: | DNA (16-mer), Sal-like protein 4, ZINC ION | | 著者 | Ru, W, Xu, C. | | 登録日 | 2022-06-11 | | 公開日 | 2022-10-26 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.723 Å) | | 主引用文献 | Structural studies of SALL family protein zinc finger cluster domains in complex with DNA reveal preferential binding to an AATA tetranucleotide motif.
J.Biol.Chem., 298, 2022
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8DTX
 | | Crystal structure of SARS-CoV-2 spike stem helix peptide in complex with neutralizing antibody COV89-22 | | 分子名称: | COV89-22 heavy chain, COV89-22 light chain, Spike protein S2' stem helix peptide | | 著者 | Lin, T.H, Lee, C.C.D, Wilson, I.A. | | 登録日 | 2022-07-26 | | 公開日 | 2022-11-23 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Rare, convergent antibodies targeting the stem helix broadly neutralize diverse betacoronaviruses.
Cell Host Microbe, 31, 2023
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8DTR
 | | Crystal structure of SARS-CoV-2 spike stem helix peptide in complex with neutralizing antibody COV30-14 | | 分子名称: | COV30-14 heavy chain, COV30-14 light chain, Spike protein S2' stem helix peptide | | 著者 | Lee, C.C.D, Lin, T.H, Wilson, I.A. | | 登録日 | 2022-07-26 | | 公開日 | 2022-11-23 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Rare, convergent antibodies targeting the stem helix broadly neutralize diverse betacoronaviruses.
Cell Host Microbe, 31, 2023
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8DTT
 | | Crystal structure of SARS-CoV-2 spike stem helix peptide in complex with neutralizing antibody COV93-03 | | 分子名称: | COV93-03 heavy chain, COV93-03 light chain, Spike protein S2' stem helix peptide | | 著者 | Lee, C.C.D, Lin, T.H, Wilson, I.A. | | 登録日 | 2022-07-26 | | 公開日 | 2022-11-23 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Rare, convergent antibodies targeting the stem helix broadly neutralize diverse betacoronaviruses.
Cell Host Microbe, 31, 2023
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7U2Q
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7U2T
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8FBO
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8FBN
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8FBJ
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8FBI
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8FBK
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8UR5
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8UR7
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4G2L
 | | Human PDE9 in complex with selective compound | | 分子名称: | 1-cyclopentyl-6-{(1R)-1-[3-(pyrimidin-2-yl)azetidin-1-yl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ... | | 著者 | Liu, S. | | 登録日 | 2012-07-12 | | 公開日 | 2013-05-29 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors.
J.Med.Chem., 55, 2012
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