1Q79
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![BU of 1q79 by Molmil](/molmil-images/mine/1q79) | CRYSTAL STRUCTURE OF MAMMALIAN POLY(A) POLYMERASE | 分子名称: | 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, MANGANESE (II) ION, ... | 著者 | Martin, G, Moglich, A, Keller, W, Doublie, S. | 登録日 | 2003-08-16 | 公開日 | 2004-09-07 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Biochemical and structural insights into substrate binding and catalytic mechanism of mammalian poly(A) polymerase. J.Mol.Biol., 341, 2004
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1Q78
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![BU of 1q78 by Molmil](/molmil-images/mine/1q78) | Crystal structure of poly(A) polymerase in complex with 3'-dATP and magnesium chloride | 分子名称: | 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Poly(A) polymerase alpha | 著者 | Martin, G, Moglich, A, Keller, W, Doublie, S. | 登録日 | 2003-08-16 | 公開日 | 2004-09-07 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Biochemical and structural insights into substrate binding and catalytic mechanism of mammalian poly(A) polymerase. J.Mol.Biol., 341, 2004
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1F5A
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![BU of 1f5a by Molmil](/molmil-images/mine/1f5a) | CRYSTAL STRUCTURE OF MAMMALIAN POLY(A) POLYMERASE | 分子名称: | 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, POLY(A) POLYMERASE, ... | 著者 | Martin, G, Keller, W, Doublie, S. | 登録日 | 2000-06-13 | 公開日 | 2000-09-13 | 最終更新日 | 2022-12-21 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structure of mammalian poly(A) polymerase in complex with an analog of ATP. EMBO J., 19, 2000
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4LT6
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![BU of 4lt6 by Molmil](/molmil-images/mine/4lt6) | Crystal Structure of human poly(A) polymerase gamma | 分子名称: | 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Poly(A) polymerase gamma | 著者 | Yang, Q, Nausch, L, Martin, G, Keller, W, Doublie, S. | 登録日 | 2013-07-23 | 公開日 | 2013-10-09 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | 主引用文献 | Crystal structure of human poly(a) polymerase gamma reveals a conserved catalytic core for canonical poly(a) polymerases. J.Mol.Biol., 426, 2014
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3BHO
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![BU of 3bho by Molmil](/molmil-images/mine/3bho) | |
3BAP
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![BU of 3bap by Molmil](/molmil-images/mine/3bap) | |
6GWJ
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![BU of 6gwj by Molmil](/molmil-images/mine/6gwj) | Human OSGEP / LAGE3 / GON7 complex | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, EKC/KEOPS complex subunit GON7, ... | 著者 | Missoury, S, Liger, D, Durand, D, Collinet, B, Tilbeurgh, V.H. | 登録日 | 2018-06-25 | 公開日 | 2019-07-03 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Defects in t 6 A tRNA modification due to GON7 and YRDC mutations lead to Galloway-Mowat syndrome. Nat Commun, 10, 2019
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1NF3
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![BU of 1nf3 by Molmil](/molmil-images/mine/1nf3) | Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6 | 分子名称: | G25K GTP-binding protein, placental isoform, MAGNESIUM ION, ... | 著者 | Garrard, S.M, Capaldo, C.T, Gao, L, Rosen, M.K, Macara, I.G, Tomchick, D.R. | 登録日 | 2002-12-12 | 公開日 | 2003-03-04 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6 Embo J., 22, 2003
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6BR6
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![BU of 6br6 by Molmil](/molmil-images/mine/6br6) | N2 neuraminidase in complex with a novel antiviral compound | 分子名称: | (1R)-4-acetamido-3-amino-1,5-anhydro-2,3,4-trideoxy-1-sulfo-D-glycero-D-galacto-octitol, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Li, L.H, Ve, T, Pascolutti, M, Hadhazi, A, Bailly, B, Thomson, R.J, Gao, G.F, von Itzstein, M. | 登録日 | 2017-11-30 | 公開日 | 2018-03-07 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.03983879 Å) | 主引用文献 | A Sulfonozanamivir Analogue Has Potent Anti-influenza Virus Activity. ChemMedChem, 13, 2018
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6BR5
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![BU of 6br5 by Molmil](/molmil-images/mine/6br5) | N2 neuraminidase in complex with a novel antiviral compound | 分子名称: | (1R)-4-acetamido-1,5-anhydro-3-carbamimidamido-2,3,4-trideoxy-1-sulfo-D-glycero-D-galacto-octitol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Li, L.H, Ve, T, Pascolutti, M, Hadhazi, A, Bailly, B, Thomson, R.J, Gao, G.F, von Itzstein, M. | 登録日 | 2017-11-30 | 公開日 | 2018-03-07 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.0379076 Å) | 主引用文献 | A Sulfonozanamivir Analogue Has Potent Anti-influenza Virus Activity. ChemMedChem, 13, 2018
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7OLI
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![BU of 7oli by Molmil](/molmil-images/mine/7oli) | Crystal structure of Pab-AGOG in complex with 8-oxoguanosine | 分子名称: | 1,2-ETHANEDIOL, 2'-DEOXY-8-OXOGUANOSINE, N-glycosylase/DNA lyase | 著者 | Coste, F, Goffinont, S, Flament, D, Castaing, B. | 登録日 | 2021-05-20 | 公開日 | 2022-06-01 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structural and functional determinants of the archaeal 8-oxoguanine-DNA glycosylase AGOG for DNA damage recognition and processing. Nucleic Acids Res., 50, 2022
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7OLB
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![BU of 7olb by Molmil](/molmil-images/mine/7olb) | Crystal structure of Pab-AGOG, an 8-oxoguanine DNA glycosylase from Pyrococcus abyssi | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, CITRIC ACID, ... | 著者 | Coste, F, Goffinont, S, Flament, D, Castaing, B. | 登録日 | 2021-05-19 | 公開日 | 2022-06-01 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Structural and functional determinants of the archaeal 8-oxoguanine-DNA glycosylase AGOG for DNA damage recognition and processing. Nucleic Acids Res., 50, 2022
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7OU3
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![BU of 7ou3 by Molmil](/molmil-images/mine/7ou3) | Crystal structure of Tga-AGOG, an 8-oxoguanine DNA glycosylase from Thermococcus gammatolerans | 分子名称: | CHLORIDE ION, GLYCEROL, N-glycosylase/DNA lyase | 著者 | Coste, F, Confalonieri, F, Castaing, B. | 登録日 | 2021-06-11 | 公開日 | 2022-06-22 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Structural and functional determinants of the archaeal 8-oxoguanine-DNA glycosylase AGOG for DNA damage recognition and processing. Nucleic Acids Res., 50, 2022
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7OUE
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![BU of 7oue by Molmil](/molmil-images/mine/7oue) | Crystal structure of a trapped Pab-AGOG/single-standed DNA covalent intermediate | 分子名称: | DNA (5'-D(*TP*TP*TP*(PED)P*TP*TP*TP*CP*T)-3'), N-glycosylase/DNA lyase, PHOSPHATE ION, ... | 著者 | Coste, F, Goffinont, S, Flament, D, Castaing, B. | 登録日 | 2021-06-11 | 公開日 | 2022-06-22 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Structural and functional determinants of the archaeal 8-oxoguanine-DNA glycosylase AGOG for DNA damage recognition and processing. Nucleic Acids Res., 50, 2022
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7P0W
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![BU of 7p0w by Molmil](/molmil-images/mine/7p0w) | Crystal structure of a trapped Pab-AGOG/double-standed DNA covalent intermediate (DNA containing thymine opposite to lesion) | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, DNA (5'-D(*AP*GP*AP*AP*AP*TP*AP*AP*A)-3'), DNA (5'-D(*TP*TP*TP*(PED)P*TP*TP*TP*CP*T)-3'), ... | 著者 | Coste, F, Goffinont, S, Flament, D, Castaing, B. | 登録日 | 2021-06-30 | 公開日 | 2022-07-13 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.12 Å) | 主引用文献 | Structural and functional determinants of the archaeal 8-oxoguanine-DNA glycosylase AGOG for DNA damage recognition and processing. Nucleic Acids Res., 50, 2022
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7OY7
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![BU of 7oy7 by Molmil](/molmil-images/mine/7oy7) | Crystal structure of a trapped Pab-AGOG/double-standed DNA covalent intermediate (DNA containing cytosine opposite to lesion) | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, DNA (5'-D(*AP*GP*AP*AP*AP*CP*AP*AP*A)-3'), DNA (5'-D(*TP*TP*TP*(PED)P*TP*TP*TP*CP*T)-3'), ... | 著者 | Coste, F, Goffinont, S, Flament, D, Castaing, B. | 登録日 | 2021-06-23 | 公開日 | 2022-07-13 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural and functional determinants of the archaeal 8-oxoguanine-DNA glycosylase AGOG for DNA damage recognition and processing. Nucleic Acids Res., 50, 2022
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7P8L
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![BU of 7p8l by Molmil](/molmil-images/mine/7p8l) | Crystal structure of Pyrococcus abyssi 8-oxoguanine DNA glycosylase (PabAGOG) in complex with dsDNA containing cytosine opposite to 8-oxoG | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, DNA (5'-D(*AP*GP*AP*AP*AP*CP*AP*AP*A)-3'), DNA (5'-D(*TP*TP*TP*(8OG)P*TP*TP*TP*CP*T)-3'), ... | 著者 | Coste, F, Flament, D, Castaing, B. | 登録日 | 2021-07-23 | 公開日 | 2022-08-03 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Structural and functional determinants of the archaeal 8-oxoguanine-DNA glycosylase AGOG for DNA damage recognition and processing. Nucleic Acids Res., 50, 2022
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7P9Z
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![BU of 7p9z by Molmil](/molmil-images/mine/7p9z) | Crystal structure of a trapped Pab-AGOG/double-standed DNA covalent intermediate (DNA containing adenine opposite to lesion) | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, DNA (5'-D(*AP*GP*AP*AP*AP*AP*AP*AP*A)-3'), DNA (5'-D(*TP*TP*TP*(PED)*TP*TP*TP*CP*T)-3'), ... | 著者 | Coste, F, Goffinont, S, Flament, D, Castaing, B. | 登録日 | 2021-07-28 | 公開日 | 2022-08-10 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.33 Å) | 主引用文献 | Structural and functional determinants of the archaeal 8-oxoguanine-DNA glycosylase AGOG for DNA damage recognition and processing. Nucleic Acids Res., 50, 2022
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4BD3
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![BU of 4bd3 by Molmil](/molmil-images/mine/4bd3) | |
4MXF
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![BU of 4mxf by Molmil](/molmil-images/mine/4mxf) | |
8E23
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![BU of 8e23 by Molmil](/molmil-images/mine/8e23) | Human DNA polymerase theta in complex with allosteric inhibitor | 分子名称: | 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*GP*TP*CP*CP*AP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*C)-3'), DNA (5'-D(*GP*C*GP*GP*CP*TP*GP*TP*CP*AP*TP*TP*G)-3'), ... | 著者 | Mader, P, Pau, V.P.T, Sicheri, F. | 登録日 | 2022-08-13 | 公開日 | 2022-09-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Identification of RP-6685 , an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Pol theta. J.Med.Chem., 65, 2022
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8E24
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![BU of 8e24 by Molmil](/molmil-images/mine/8e24) | Human DNA polymerase theta in complex with allosteric inhibitor | 分子名称: | 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, 2-[2,4-bis(trifluoromethyl)phenyl]-N-phenyl-N-[3-(pyridazin-3-yl)prop-2-yn-1-yl]acetamide, DNA, ... | 著者 | Mader, P, Pau, V.P.T, Sicheri, F. | 登録日 | 2022-08-13 | 公開日 | 2022-09-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | 主引用文献 | Identification of RP-6685 , an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Pol theta. J.Med.Chem., 65, 2022
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3MVH
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![BU of 3mvh by Molmil](/molmil-images/mine/3mvh) | Crystal structure of Akt-1-inhibitor complexes | 分子名称: | GSK3-beta peptide, MANGANESE (II) ION, N-{[(3S)-3-amino-1-(5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-yl]methyl}-2,4-difluorobenzamide, ... | 著者 | Pandit, J. | 登録日 | 2010-05-04 | 公開日 | 2010-06-02 | 最終更新日 | 2021-10-06 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Design of selective, ATP-competitive inhibitors of Akt. J.Med.Chem., 53, 2010
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3MV5
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![BU of 3mv5 by Molmil](/molmil-images/mine/3mv5) | Crystal structure of Akt-1-inhibitor complexes | 分子名称: | (3R)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-amine, GSK3-beta peptide, MANGANESE (II) ION, ... | 著者 | Pandit, J. | 登録日 | 2010-05-03 | 公開日 | 2010-06-02 | 最終更新日 | 2021-10-06 | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | 主引用文献 | Design of selective, ATP-competitive inhibitors of Akt. J.Med.Chem., 53, 2010
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3MVJ
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![BU of 3mvj by Molmil](/molmil-images/mine/3mvj) | Human cyclic AMP-dependent protein kinase PKA inhibitor complex | 分子名称: | (3R)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-amine, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha | 著者 | Pandit, J, Vajdos, F. | 登録日 | 2010-05-04 | 公開日 | 2010-06-02 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | Design of selective, ATP-competitive inhibitors of Akt. J.Med.Chem., 53, 2010
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