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4MCV
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BU of 4mcv by Molmil
Star 12 bound to analog-sensitive Src kinase
分子名称: (7S)-12-(4-aminobutyl)-7-(2-methylpropyl)-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one, Proto-oncogene tyrosine-protein kinase Src
著者Lopez, M.S, Shokat, K.M.
登録日2013-08-21
公開日2013-11-20
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.73 Å)
主引用文献Staurosporine-derived inhibitors broaden the scope of analog-sensitive kinase technology.
J.Am.Chem.Soc., 135, 2013
4LGH
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BU of 4lgh by Molmil
Crystal structure of 1NM-PP1 bound to analog-sensitive Src kinase
分子名称: 1-tert-butyl-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Proto-oncogene tyrosine-protein kinase Src
著者Lopez, M.S, Dar, A.C, Shokat, K.M.
登録日2013-06-27
公開日2013-08-07
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.84 Å)
主引用文献Structure-guided inhibitor design expands the scope of analog-sensitive kinase technology.
Acs Chem.Biol., 8, 2013
4LGG
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BU of 4lgg by Molmil
Structure of 3MB-PP1 bound to analog-sensitive Src kinase
分子名称: 1-tert-butyl-3-(3-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Proto-oncogene tyrosine-protein kinase Src
著者Lopez, M.S, Dar, A.C, Shokat, K.M.
登録日2013-06-27
公開日2013-08-07
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Structure-guided inhibitor design expands the scope of analog-sensitive kinase technology.
Acs Chem.Biol., 8, 2013
5W91
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BU of 5w91 by Molmil
Toxoplasma Gondii CDPK1 in complex with inhibitor LZH118
分子名称: 1-tert-butyl-N~3~-(3-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine, CALCIUM ION, Calmodulin-domain protein kinase 1
著者El Bakkouri, M, Lovato, D, Loppnau, P, Lin, Y.H, Rutaganaria, F, Lopez, M.S, Shokat, L, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Sibley, D, Hui, R, Walker, J.R, Structural Genomics Consortium (SGC)
登録日2017-06-22
公開日2017-08-30
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Toxoplasma Gondii CDPK1 in complex with inhibitor LZH118
To be published
5W9R
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BU of 5w9r by Molmil
Toxoplasma Gondii CDPK1 in complex with inhibitor LJQ138
分子名称: 1-tert-butyl-3-[(1H-indol-3-yl)methyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1
著者El Bakkouri, M, Lovato, D, Loppnau, P, Lin, Y.H, Rutaganaria, F, Lopez, M.S, Shokat, L, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Sibley, D, Hui, R, Walker, J.R.
登録日2017-06-23
公開日2017-08-02
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Toxoplasma Gondii CDPK1 in complex with inhibitor LJQ138
To be published
5W80
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BU of 5w80 by Molmil
Toxoplasma Gondii CDPK1 in complex with inhibitor GXJ-237
分子名称: 3-(3-chlorophenoxy)-1-[(piperidin-4-yl)methyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine, CALCIUM ION, Calmodulin-domain protein kinase 1
著者El Bakkouri, M, Lovato, D, Loppnau, P, Lin, Y.H, Rutaganaria, F, Lopez, M.S, Shokat, L, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Sibley, D, Walker, J.R, Structural Genomics Consortium (SGC)
登録日2017-06-21
公開日2017-07-19
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Toxoplasma Gondii CDPK1 in complex with inhibitor GXJ-237
To be published
5W9E
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BU of 5w9e by Molmil
Toxoplasma Gondii CDPK1 in complex with inhibitor GXJ-186
分子名称: 1-tert-butyl-3-[(3-chlorophenyl)sulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1
著者El Bakkouri, M, Lovato, D, Loppnau, P, Lin, Y.H, Rutaganaria, F, Lopez, M.S, Shokat, L, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Sibley, D, Hui, R, Walker, J.R.
登録日2017-06-23
公開日2017-08-02
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.44 Å)
主引用文献Toxoplasma Gondii CDPK1 in complex with inhibitor GXJ-186
To be published
5W8R
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BU of 5w8r by Molmil
Toxoplasma Gondii CDPK1 in complex with inhibitor 3CIB-PPI
分子名称: 1-tert-butyl-3-[(3-chlorophenyl)methyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine, CALCIUM ION, Calmodulin-domain protein kinase 1
著者El Bakkouri, M, Lovato, D, Loppnau, P, Lin, Y.H, Rutaganaria, F, Lopez, M.S, Shokat, L, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Sibley, D, Hui, R, Walker, J.R, Structural Genomics Consortium (SGC)
登録日2017-06-22
公開日2017-07-19
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Toxoplasma Gondii CDPK1 in complex with inhibitor 3CIB-PPI
To be published
3EL8
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BU of 3el8 by Molmil
Crystal structure of c-Src in complex with pyrazolopyrimidine 5
分子名称: 1-{4-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]phenyl}-3-[3-(trifluoromethyl)phenyl]urea, Proto-oncogene tyrosine-protein kinase Src
著者Dar, A.C, Lopez, M.S, Shokat, K.M.
登録日2008-09-20
公開日2008-10-28
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Small molecule recognition of c-Src via the Imatinib-binding conformation.
Chem.Biol., 15, 2008
3EL7
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BU of 3el7 by Molmil
Crystal structure of c-Src in complex with pyrazolopyrimidine 3
分子名称: 1-{3-[(4-amino-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)methyl]phenyl}-3-[3-(trifluoromethyl)phenyl]urea, Proto-oncogene tyrosine-protein kinase Src
著者Dar, A.C, Lopez, M.S, Shokat, K.M.
登録日2008-09-20
公開日2008-10-28
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Small molecule recognition of c-Src via the Imatinib-binding conformation.
Chem.Biol., 15, 2008
3QLG
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BU of 3qlg by Molmil
Crystal structure of the L317I mutant of the C-src tyrosine kinase domain complexed with dasatinib
分子名称: N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, Proto-oncogene tyrosine-protein kinase Src
著者Boubeva, R, Pernot, L, Perozzo, R, Scapozza, L.
登録日2011-02-02
公開日2012-02-08
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献A single amino-acid dictates the dynamics of the switch between active and inactive C-src conformation
To be Published
3QLF
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BU of 3qlf by Molmil
Crystal structure of the L317I mutant of the C-src tyrosine kinase domain complexed with pyrazolopyrimidine 5
分子名称: 1-{4-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]phenyl}-3-[3-(trifluoromethyl)phenyl]urea, Proto-oncogene tyrosine-protein kinase Src
著者Boubeva, R, Pernot, L, Perozzo, R, Scapozza, L.
登録日2011-02-02
公開日2012-02-08
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献A single amino-acid dictates the dynamics of the switch between active and inactive C-src conformation
To be Published

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件を2024-07-10に公開中

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