3QLF

Crystal structure of the L317I mutant of the C-src tyrosine kinase domain complexed with pyrazolopyrimidine 5

Summary for 3QLF

• Entry DOI: 10.2210/pdb3qlf/pdb
• Related: 3EL8 3OEZ 3OF0 3QLG
• Descriptor: Proto-oncogene tyrosine-protein kinase Src, 1-{4-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]phenyl}-3-[3-(trifluoromethyl)phenyl]urea (3 entities in total)
• Functional Keywords: c-src l317i mutant, tyrosine kinase, transferase, pyrazolopyrimidine 5
• Biological source: Gallus gallus (bantam,chickens)
• Cellular location: Cell membrane (By similarity): P00523
• Total number of polymer chains: 2
• Total formula weight: 66364.16

Authors

Boubeva, R.,Pernot, L.,Perozzo, R.,Scapozza, L. (deposition date: 2011-02-02, release date: 2012-02-08, Last modification date: 2023-09-13)

• Primary citation: Boubeva, R.,Pernot, L.,Cristiani, A.,Moretti, L.,Berteotti, A.,Perozzo, R.,Gervasio, F.,Scapozza, L.; A single amino-acid dictates the dynamics of the switch between active and inactive C-src conformation; To be Published,

Experimental method

X-RAY DIFFRACTION (2.75 Å)