3QLG

Crystal structure of the L317I mutant of the C-src tyrosine kinase domain complexed with dasatinib

Summary for 3QLG

• Entry DOI: 10.2210/pdb3qlg/pdb
• Related: 3G5D 3OEZ 3OF0 3QLF
• Descriptor: Proto-oncogene tyrosine-protein kinase Src, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE (3 entities in total)
• Functional Keywords: c-src l317i mutant, tyrosine kinase, transferase, dasatinib
• Biological source: Gallus gallus (bantam,chickens)
• Cellular location: Cell membrane (By similarity): P00523
• Total number of polymer chains: 2
• Total formula weight: 66429.30

Authors

Boubeva, R.,Pernot, L.,Perozzo, R.,Scapozza, L. (deposition date: 2011-02-02, release date: 2012-02-08, Last modification date: 2023-09-13)

• Primary citation: Boubeva, R.,Pernot, L.,Cristiani, A.,Moretti, L.,Berteotti, A.,Perozzo, R.,Gervasio, F.,Scapozza, L.; A single amino-acid dictates the dynamics of the switch between active and inactive C-src conformation; To be Published,

Experimental method

X-RAY DIFFRACTION (2.75 Å)