3QLG
Crystal structure of the L317I mutant of the C-src tyrosine kinase domain complexed with dasatinib
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Proto-oncogene tyrosine-protein kinase Src | polymer | 286 | 32726.6 | 2 | UniProt (P00523) Pfam (PF07714) In PDB | Gallus gallus (bantam chickens) | Proto-oncogene c-Src, pp60c-src, p60-Src |
2 | A, B | N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE | non-polymer | 488.0 | 2 | Chemie (1N1) | |||
3 | water | water | 18.0 | 180 | Chemie (HOH) |
Sequence modifications
A, B: 251 - 533 (UniProt: P00523)
PDB | External Database | Details |
---|---|---|
Gly 248 | - | expression tag |
His 249 | - | expression tag |
Met 250 | - | expression tag |
Ile 317 | Leu 317 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 65453.3 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 976.0 | |
All* | Total formula weight | 66429.3 |