6OHT
| Structure of EBP and U18666A | 分子名称: | 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase, 3beta-(2-Diethylaminoethoxy)androst-5-en-17-one | 著者 | Long, T, Li, X. | 登録日 | 2019-04-06 | 公開日 | 2019-06-19 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition. Nat Commun, 10, 2019
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6OHU
| Structure of EBP and tamoxifen | 分子名称: | (Z)-2-[4-(1,2)-DIPHENYL-1-BUTENYL)-PHENOXY]-N,N-DIMETHYLETHANAMINE, 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase | 著者 | Long, T, Li, X. | 登録日 | 2019-04-06 | 公開日 | 2019-06-19 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (3.526 Å) | 主引用文献 | Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition. Nat Commun, 10, 2019
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6UOX
| Structure of itraconazole-bound NPC1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(3-bromo-4-{4-[4-({(2R,4S)-2-(2,4-dichlorophenyl)-2-[(1H-1,2,4-triazol-1-yl)methyl]-1,3-dioxolan-4-yl}methoxy)phenyl]piperazin-1-yl}phenyl)-2-[(2S)-butan-2-yl]-2,4-dihydro-3H-1,2,4-triazol-3-one, ... | 著者 | Long, T, Li, X. | 登録日 | 2019-10-15 | 公開日 | 2020-01-15 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (4.13 Å) | 主引用文献 | Structural basis for itraconazole-mediated NPC1 inhibition. Nat Commun, 11, 2020
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9B4F
| Structure of human PSS1-P269S | 分子名称: | CALCIUM ION, Phosphatidylserine synthase 1 | 著者 | Long, T, Li, X. | 登録日 | 2024-03-20 | 公開日 | 2024-09-04 | 最終更新日 | 2024-09-11 | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | 主引用文献 | Molecular insights into human phosphatidylserine synthase 1 reveal its inhibition promotes LDL uptake. Cell, 2024
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9B4E
| Structure of wild type human PSS1 | 分子名称: | (2R)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dihexadecanoate, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, CALCIUM ION, ... | 著者 | Long, T, Li, X. | 登録日 | 2024-03-20 | 公開日 | 2024-09-04 | 最終更新日 | 2024-09-11 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Molecular insights into human phosphatidylserine synthase 1 reveal its inhibition promotes LDL uptake. Cell, 2024
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9B4G
| Structure of inhibitor-bound human PSS1 | 分子名称: | (2R)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dihexadecanoate, (7P)-7-[(4S)-4-{4-[3,5-bis(trifluoromethyl)phenoxy]phenyl}-5-(2,2-difluoropropyl)-6-oxo-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl]-1,3-benzoxazol-2(3H)-one, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, ... | 著者 | Long, T, Li, X. | 登録日 | 2024-03-20 | 公開日 | 2024-09-04 | 最終更新日 | 2024-09-11 | 実験手法 | ELECTRON MICROSCOPY (2.87 Å) | 主引用文献 | Molecular insights into human phosphatidylserine synthase 1 reveal its inhibition promotes LDL uptake. Cell, 2024
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8T05
| Structure of Ciona Myomaker bound to Fab1A1 | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1A1 Fab heavy chain, 1A1 Fab light chain, ... | 著者 | Long, T, Li, X. | 登録日 | 2023-05-31 | 公開日 | 2023-09-27 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | Cryo-EM structures of Myomaker reveal a molecular basis for myoblast fusion. Nat.Struct.Mol.Biol., 30, 2023
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8T03
| Structure of mouse Myomaker bound to Fab18G7 in detergent | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 18G7 Fab heavy chain, 18G7 Fab light chain, ... | 著者 | Long, T, Li, X. | 登録日 | 2023-05-31 | 公開日 | 2023-09-27 | 最終更新日 | 2023-11-22 | 実験手法 | ELECTRON MICROSCOPY (2.72 Å) | 主引用文献 | Cryo-EM structures of Myomaker reveal a molecular basis for myoblast fusion. Nat.Struct.Mol.Biol., 30, 2023
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8T07
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8T06
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8T04
| Structure of mouse Myomaker bound to Fab18G7 in nanodiscs | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 18G7 Fab heavy chain, 18G7 Fab light chain, ... | 著者 | Long, T, Li, X. | 登録日 | 2023-05-31 | 公開日 | 2023-09-27 | 最終更新日 | 2023-11-22 | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | 主引用文献 | Cryo-EM structures of Myomaker reveal a molecular basis for myoblast fusion. Nat.Struct.Mol.Biol., 30, 2023
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6VUM
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7N4X
| Structure of human NPC1L1 mutant-W347R | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | 著者 | Li, X, Long, T. | 登録日 | 2021-06-04 | 公開日 | 2021-09-01 | 最終更新日 | 2022-03-16 | 実験手法 | ELECTRON MICROSCOPY (3.33 Å) | 主引用文献 | Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption. Sci Adv, 7, 2021
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7N4U
| Structure of human NPC1L1 | 分子名称: | (2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Li, X, Long, T. | 登録日 | 2021-06-04 | 公開日 | 2021-09-01 | 最終更新日 | 2022-03-16 | 実験手法 | ELECTRON MICROSCOPY (3.34 Å) | 主引用文献 | Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption. Sci Adv, 7, 2021
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7N4V
| Structure of cholesterol-bound human NPC1L1 | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Li, X, Long, T. | 登録日 | 2021-06-04 | 公開日 | 2021-09-01 | 最終更新日 | 2022-03-16 | 実験手法 | ELECTRON MICROSCOPY (3.58 Å) | 主引用文献 | Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption. Sci Adv, 7, 2021
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7R8E
| The structure of human ABCG1 E242Q complexed with ATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, Isoform 4 of ATP-binding cassette sub-family G member 1, ... | 著者 | Sun, Y, Li, X, Long, T. | 登録日 | 2021-06-26 | 公開日 | 2021-09-08 | 実験手法 | ELECTRON MICROSCOPY (3.68 Å) | 主引用文献 | Molecular basis of cholesterol efflux via ABCG subfamily transporters. Proc.Natl.Acad.Sci.USA, 118, 2021
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7R8D
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7R8A
| The structure of human ABCG5/ABCG8 purified from mammalian cells | 分子名称: | 2C7 Fab heavy chain, 2C7 Fab light chain, ATP-binding cassette sub-family G member 5, ... | 著者 | Sun, Y, Li, X, Long, T. | 登録日 | 2021-06-26 | 公開日 | 2021-09-08 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Molecular basis of cholesterol efflux via ABCG subfamily transporters. Proc.Natl.Acad.Sci.USA, 118, 2021
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7R8B
| The structure of human ABCG5/ABCG8 supplemented with cholesterol | 分子名称: | 2C7 Fab heavy chain, 2C7 Fab light chain, ATP-binding cassette sub-family G member 5, ... | 著者 | Sun, Y, Li, X, Long, T. | 登録日 | 2021-06-26 | 公開日 | 2021-09-08 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Molecular basis of cholesterol efflux via ABCG subfamily transporters. Proc.Natl.Acad.Sci.USA, 118, 2021
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7R88
| The structure of human ABCG5-I529W/ABCG8-WT | 分子名称: | 2C7 Fab heavy chain, 2C7 Fab light chain, ATP-binding cassette sub-family G member 5, ... | 著者 | Sun, Y, Li, X, Long, T. | 登録日 | 2021-06-26 | 公開日 | 2021-09-08 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Molecular basis of cholesterol efflux via ABCG subfamily transporters. Proc.Natl.Acad.Sci.USA, 118, 2021
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7R89
| The structure of human ABCG5/ABCG8 purified from yeast | 分子名称: | 2C7 Fab heavy chain, 2C7 Fab light chain, ATP-binding cassette sub-family G member 5, ... | 著者 | Sun, Y, Li, X, Long, T. | 登録日 | 2021-06-26 | 公開日 | 2021-09-08 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Molecular basis of cholesterol efflux via ABCG subfamily transporters. Proc.Natl.Acad.Sci.USA, 118, 2021
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7R87
| The structure of human ABCG5-WT/ABCG8-I419E | 分子名称: | 2C7 Fab heavy chain, 2C7 Fab light chain, ATP-binding cassette sub-family G member 5, ... | 著者 | Sun, Y, Li, X, Long, T. | 登録日 | 2021-06-26 | 公開日 | 2021-09-08 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Molecular basis of cholesterol efflux via ABCG subfamily transporters. Proc.Natl.Acad.Sci.USA, 118, 2021
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7R8C
| The structure of human ABCG1 | 分子名称: | Isoform 4 of ATP-binding cassette sub-family G member 1 | 著者 | Sun, Y, Li, X, Long, T. | 登録日 | 2021-06-26 | 公開日 | 2021-09-08 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Molecular basis of cholesterol efflux via ABCG subfamily transporters. Proc.Natl.Acad.Sci.USA, 118, 2021
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6XBK
| Structure of human SMO-G111C/I496C complex with Gi | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Qi, X, Long, T, Li, X. | 登録日 | 2020-06-06 | 公開日 | 2020-09-30 | 最終更新日 | 2020-11-25 | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | 主引用文献 | Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling. Nat.Chem.Biol., 16, 2020
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6XBJ
| Structure of human SMO-D384R complex with Gi | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Qi, X, Long, T, Li, X. | 登録日 | 2020-06-06 | 公開日 | 2020-09-30 | 最終更新日 | 2020-11-25 | 実験手法 | ELECTRON MICROSCOPY (3.88 Å) | 主引用文献 | Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling. Nat.Chem.Biol., 16, 2020
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