7P6X
| Cryo-Em structure of the hexameric RUVBL1-RUVBL2 in complex with ZNHIT2 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, RuvB-like 1, RuvB-like 2 | 著者 | Llorca, O, Serna, M, Fernandez-Leiro, R. | 登録日 | 2021-07-18 | 公開日 | 2021-12-15 | 最終更新日 | 2023-01-25 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | CryoEM of RUVBL1-RUVBL2-ZNHIT2, a complex that interacts with pre-mRNA-processing-splicing factor 8. Nucleic Acids Res., 50, 2022
|
|
8Q62
| Early closed conformation of the g-tubulin ring complex | 分子名称: | Gamma-tubulin complex component 2, Gamma-tubulin complex component 3, Gamma-tubulin complex component 4, ... | 著者 | Llorca, O, Serna, M, Fernandez-Leiro, R. | 登録日 | 2023-08-10 | 公開日 | 2024-02-07 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.72 Å) | 主引用文献 | Transition of human gamma-tubulin ring complex into a closed conformation during microtubule nucleation. Science, 383, 2024
|
|
9EMC
| |
9EMA
| RUVBL1/2 in complex with ATP and CB-6644 inhibitor | 分子名称: | 5-chloranyl-2-ethoxy-4-fluoranyl-~{N}-[4-[[3-(methoxymethyl)-1-oxidanylidene-6,7-dihydro-5~{H}-pyrazolo[1,2-a][1,2]benzodiazepin-2-yl]amino]-2,2-dimethyl-4-oxidanylidene-butyl]benzamide, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Lopez-Perrote, A, Llorca, O, Garcia-Martin, C. | 登録日 | 2024-03-07 | 公開日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Mechanism of allosteric inhibition of RUVBL1-RUVBL2 by the small-molecule CB-6644 Cell Rep Phys Sci, 2024
|
|
7OLE
| Cryo-EM structure of the TELO2-TTI1-TTI2-RUVBL1-RUVBL2 complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, RuvB-like 1, RuvB-like 2, ... | 著者 | Pal, M, Llorca, O, Pearl, L. | 登録日 | 2021-05-19 | 公開日 | 2021-07-07 | 最終更新日 | 2021-10-06 | 実験手法 | ELECTRON MICROSCOPY (3.41 Å) | 主引用文献 | Structure of the TELO2-TTI1-TTI2 complex and its function in TOR recruitment to the R2TP chaperone. Cell Rep, 36, 2021
|
|
6FO1
| Human R2TP subcomplex containing 1 RUVBL1-RUVBL2 hexamer bound to 1 RBD domain from RPAP3. | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, RNA polymerase II-associated protein 3, RuvB-like 1, ... | 著者 | Martino, F, Munoz-Hernandez, H, Rodriguez, C.F, Pearl, L.H, Llorca, O. | 登録日 | 2018-02-05 | 公開日 | 2018-04-04 | 最終更新日 | 2019-12-11 | 実験手法 | ELECTRON MICROSCOPY (3.57 Å) | 主引用文献 | RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex. Nat Commun, 9, 2018
|
|
6QI9
| Truncated human R2TP complex, structure 4 (ADP-empty) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, RuvB-like 1, RuvB-like 2 | 著者 | Munoz-Hernandez, H, Rodriguez, C.F, Llorca, O. | 登録日 | 2019-01-18 | 公開日 | 2019-05-15 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4.63 Å) | 主引用文献 | Structural mechanism for regulation of the AAA-ATPases RUVBL1-RUVBL2 in the R2TP co-chaperone revealed by cryo-EM. Sci Adv, 5, 2019
|
|
6QI8
| Truncated human R2TP complex, structure 3 (ADP-filled) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, RuvB-like 1, RuvB-like 2 | 著者 | Munoz-Hernandez, H, Rodriguez, C.F, Llorca, O. | 登録日 | 2019-01-18 | 公開日 | 2019-04-10 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.75 Å) | 主引用文献 | Structural mechanism for regulation of the AAA-ATPases RUVBL1-RUVBL2 in the R2TP co-chaperone revealed by cryo-EM. Sci Adv, 5, 2019
|
|
8QEY
| Structure of human Asc1/CD98hc heteromeric amino acid transporter | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4F2 cell-surface antigen heavy chain, ... | 著者 | Martinez-Molledo, M, Rullo-Tubau, J, Errasti-Murugarren, E, Palacin, M, Llorca, O. | 登録日 | 2023-09-01 | 公開日 | 2024-04-10 | 最終更新日 | 2024-04-17 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structure and mechanisms of transport of human Asc1/CD98hc amino acid transporter. Nat Commun, 15, 2024
|
|
3CF6
| Structure of Epac2 in complex with cyclic-AMP and Rap | 分子名称: | 6-(6-AMINO-PURIN-9-YL)-2-THIOXO-TETRAHYDRO-2-FURO[3,2-D][1,3,2]DIOXAPHOSPHININE-2,7-DIOL, Rap guanine nucleotide exchange factor (GEF) 4, Ras-related protein Rap-1b, ... | 著者 | Rehmann, H, Arias-Palomo, E, Hadders, M.A, Schwede, F, Llorca, O, Bos, J.L. | 登録日 | 2008-03-02 | 公開日 | 2008-07-29 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B Nature, 455, 2008
|
|
7B00
| Human LAT2-4F2hc complex in the apo-state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Digitonin, Isoform 2 of 4F2 cell-surface antigen heavy chain, ... | 著者 | Rodriguez, C.F, Escudero-Bravo, P, Garcia-Martin, C, Boskovic, J, Errasti-Murugarren, E, Palacin, M, Llorca, O. | 登録日 | 2020-11-17 | 公開日 | 2021-10-27 | 最終更新日 | 2022-02-23 | 実験手法 | ELECTRON MICROSCOPY (3.98 Å) | 主引用文献 | Structural basis for substrate specificity of heteromeric transporters of neutral amino acids. Proc Natl Acad Sci U S A, 118, 2021
|
|
4A5W
| Crystal structure of C5b6 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, COMPLEMENT C5, ... | 著者 | Hadders, M.A, Bubeck, D, Forneris, F, Pangburn, M, Llorca, O, Lea, S.M, Gros, P. | 登録日 | 2011-10-28 | 公開日 | 2012-03-14 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Assembly and Regulation of the Membrane Attack Complex Based on Structures of C5B6 and Sc5B9. Cell Rep., 1, 2012
|
|
7AHO
| RUVBL1-RUVBL2 heterohexameric ring after binding of RNA helicase DHX34 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, RuvB-like 1, RuvB-like 2 | 著者 | Lopez-Perrote, A, Rodriguez, C.F, Llorca, O. | 登録日 | 2020-09-25 | 公開日 | 2020-11-25 | 実験手法 | ELECTRON MICROSCOPY (4.18 Å) | 主引用文献 | Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM. Elife, 9, 2020
|
|
7AS4
| Recombinant human gTuRC | 分子名称: | Actin, cytoplasmic 1, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Serna, M, Fernandez-Leiro, R, Llorca, O. | 登録日 | 2020-10-26 | 公開日 | 2021-01-20 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (4.13 Å) | 主引用文献 | Assembly of the asymmetric human gamma-tubulin ring complex by RUVBL1-RUVBL2 AAA ATPase. Sci Adv, 6, 2020
|
|
6SGX
| Structure of protomer 1 of the ESX-3 core complex | 分子名称: | ESX-3 secretion system EccB3, ESX-3 secretion system protein EccC3, ESX-3 secretion system protein EccD3, ... | 著者 | Famelis, N, Rivera-Calzada, A, Llorca, O, Geibel, S. | 登録日 | 2019-08-05 | 公開日 | 2019-10-09 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Architecture of the mycobacterial type VII secretion system. Nature, 576, 2019
|
|
6SGY
| |
6SGW
| Structure of the ESX-3 core complex | 分子名称: | ESX-3 secretion system ATPase EccB3, ESX-3 secretion system protein EccC3, ESX-3 secretion system protein EccD3, ... | 著者 | Famelis, N, Rivera-Calzada, A, Llorca, O, Geibel, S. | 登録日 | 2019-08-05 | 公開日 | 2019-10-09 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Architecture of the mycobacterial type VII secretion system. Nature, 576, 2019
|
|
6SGZ
| Structure of protomer 2 of the ESX-3 core complex | 分子名称: | ESX-3 secretion system ATPase EccB3, ESX-3 secretion system protein EccC3, ESX-3 secretion system protein EccD3, ... | 著者 | Famelis, N, Rivera-Calzada, A, Llorca, O, Geibel, S. | 登録日 | 2019-08-05 | 公開日 | 2019-10-09 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Architecture of the mycobacterial type VII secretion system. Nature, 576, 2019
|
|
8AG3
| |
8AG5
| Vaccinia C16 protein bound to Ku70/Ku80 | 分子名称: | Ku70-Xrcc6, Protein C10, X-ray repair cross-complementing protein 5 | 著者 | Rivera-Calzada, A, Arribas-Bosacoma, R, Pearl, L.H, Llorca, O. | 登録日 | 2022-07-19 | 公開日 | 2022-11-09 | 最終更新日 | 2022-11-30 | 実験手法 | ELECTRON MICROSCOPY (3.47 Å) | 主引用文献 | Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus. Nat Commun, 13, 2022
|
|
8AG4
| Vaccinia C16 protein bound to Ku70/Ku80 | 分子名称: | Protein C10, X-ray repair cross-complementing protein 5, X-ray repair cross-complementing protein 6 | 著者 | Rivera-Calzada, A, Arribas-Bosacoma, R, Pearl, L.H, Llorca, O. | 登録日 | 2022-07-19 | 公開日 | 2022-11-09 | 最終更新日 | 2022-11-30 | 実験手法 | ELECTRON MICROSCOPY (2.46 Å) | 主引用文献 | Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus. Nat Commun, 13, 2022
|
|
6TY3
| FAK structure from single particle analysis of 2D crystals | 分子名称: | Focal adhesion kinase 1 | 著者 | Acebron, I, Righetto, R, Biyani, N, Chami, M, Boskovic, J, Stahlberg, H, Lietha, D. | 登録日 | 2020-01-15 | 公開日 | 2020-08-19 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (6.32 Å) | 主引用文献 | Structural basis of Focal Adhesion Kinase activation on lipid membranes. Embo J., 39, 2020
|
|
6TY4
| FAK structure with AMP-PNP from single particle analysis of 2D crystals | 分子名称: | Focal adhesion kinase 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | 著者 | Acebron, I, Righetto, R, Biyani, N, Chami, M, Boskovic, J, Stahlberg, H, Lietha, D. | 登録日 | 2020-01-15 | 公開日 | 2020-08-19 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (5.96 Å) | 主引用文献 | Structural basis of Focal Adhesion Kinase activation on lipid membranes. Embo J., 39, 2020
|
|
4IS4
| |
3C7N
| Structure of the Hsp110:Hsc70 Nucleotide Exchange Complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, CHLORIDE ION, ... | 著者 | Schuermann, J.P, Jiang, J, Hart, P.J, Sousa, R. | 登録日 | 2008-02-07 | 公開日 | 2008-05-27 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (3.115 Å) | 主引用文献 | Structure of the Hsp110:Hsc70 nucleotide exchange machine Mol.Cell, 31, 2008
|
|