3CF6

Structure of Epac2 in complex with cyclic-AMP and Rap

Summary for 3CF6

• Entry DOI: 10.2210/pdb3cf6/pdb
• Related: 2BYV
• Descriptor: Rap guanine nucleotide exchange factor (GEF) 4, Ras-related protein Rap-1b, 6-(6-AMINO-PURIN-9-YL)-2-THIOXO-TETRAHYDRO-2-FURO[3,2-D][1,3,2]DIOXAPHOSPHININE-2,7-DIOL, ... (5 entities in total)
• Functional Keywords: epac, rapgef4, rap, rap1b, camp, sp-camps, gef, gunanine nucleotide exchange factor, g-protein, gtp-binding, nucleotide-binding, signaling protein regulator-gtp-binding protein complex, signaling protein-gtp-binding protein complex, signaling protein/gtp-binding protein
• Biological source: Mus musculus (mouse); More
• Cellular location: Cell membrane: P61224
• Total number of polymer chains: 2
• Total formula weight: 99084.95

Authors

Rehmann, H.,Arias-Palomo, E.,Hadders, M.A.,Schwede, F.,Llorca, O.,Bos, J.L. (deposition date: 2008-03-02, release date: 2008-07-29, Last modification date: 2023-11-01)

• Primary citation: Rehmann, H.,Arias-Palomo, E.,Hadders, M.A.,Schwede, F.,Llorca, O.,Bos, J.L.; Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B; Nature, 455:124-127, 2008; PubMed: 18660803; DOI: 10.1038/nature07187

Experimental method

X-RAY DIFFRACTION (2.2 Å)