5KBF
 
 | | cAMP bound PfPKA-R (141-441) | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CAMP-dependent protein kinase regulatory subunit, putative | | 著者 | Littler, D.R, Gilson, P.R, Crabb, B.S, Rossjohn, J.J. | | 登録日 | 2016-06-03 | | 公開日 | 2016-10-12 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Disrupting the Allosteric Interaction between the Plasmodium falciparum cAMP-dependent Kinase and Its Regulatory Subunit.
J. Biol. Chem., 291, 2016
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2AHE
 | | Crystal structure of a soluble form of CLIC4. intercellular chloride ion channel | | 分子名称: | Chloride intracellular channel protein 4 | | 著者 | Littler, D.R, Assaad, N.N, Harrop, S.J, Brown, L.J, Pankhurst, G.J, Luciani, P, Aguilar, M.-I, Mazzanti, M, Berryman, M.A, Breit, S.N, Curmi, P.M.G. | | 登録日 | 2005-07-28 | | 公開日 | 2005-08-16 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structure of the soluble form of the redox-regulated chloride ion channel protein CLIC4.
FEBS J., 272, 2005
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6WXD
 | | SARS-CoV-2 Nsp9 RNA-replicase | | 分子名称: | Non-structural protein 9, SULFATE ION | | 著者 | Littler, D.R, Gully, B.S, Riboldi-Tunnicliffe, A, Rossjohn, J. | | 登録日 | 2020-05-10 | | 公開日 | 2020-05-20 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9.
Iscience, 23, 2020
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5K8S
 | | cAMP bound PfPKA-R (297-441) | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CAMP-dependent protein kinase regulatory subunit | | 著者 | Littler, D.R, Gilson, P.R, Crabb, B.S, Rossjohn, J.J. | | 登録日 | 2016-05-31 | | 公開日 | 2016-10-12 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | | 主引用文献 | Disrupting the Allosteric Interaction between the Plasmodium falciparum cAMP-dependent Kinase and Its Regulatory Subunit.
J. Biol. Chem., 291, 2016
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1RK4
 | | Crystal Structure of a Soluble Dimeric Form of Oxidised CLIC1 | | 分子名称: | CHLORIDE INTRACELLULAR CHANNEL PROTEIN 1 | | 著者 | Littler, D.R, Harrop, S.J, Fairlie, W.D, Brown, L.J, Pankhurst, G.J, Pankhurst, S, DeMaere, M.Z, Campbell, T.J, Bauskin, A.R, Tonini, R, Mazzanti, M, Breit, S.N, Curmi, P.M. | | 登録日 | 2003-11-20 | | 公開日 | 2003-12-02 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.792 Å) | | 主引用文献 | The Intracellular Chloride Ion Channel Protein CLIC1 Undergoes a Redox-controlled Structural Transition
J.Biol.Chem., 279, 2004
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3FY7
 | | Crystal structure of homo sapiens CLIC3 | | 分子名称: | Chloride intracellular channel protein 3, SULFATE ION | | 著者 | Littler, D.R, Curmi, P.M.G, Breit, S.N, Perrakis, A. | | 登録日 | 2009-01-22 | | 公開日 | 2009-02-24 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structure of human CLIC3 at 2 A resolution
Proteins, 78, 2010
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3G73
 | | Structure of the FOXM1 DNA binding | | 分子名称: | DNA (5'-D(P*AP*AP*AP*TP*TP*GP*TP*TP*TP*AP*TP*AP*AP*AP*CP*AP*GP*CP*CP*CP*G)-3'), DNA (5'-D(P*TP*TP*CP*GP*GP*GP*CP*TP*GP*TP*TP*TP*AP*TP*AP*AP*AP*CP*AP*AP*T)-3'), Forkhead box protein M1, ... | | 著者 | Littler, D.R, Perrakis, A, Hibbert, R.G, Medema, R.H. | | 登録日 | 2009-02-09 | | 公開日 | 2009-03-03 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | | 主引用文献 | Structure of the FoxM1 DNA-recognition domain bound to a promoter sequence
Nucleic Acids Res., 2010
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4Z9C
 | | EcPltAB Oxidized | | 分子名称: | PHOSPHATE ION, Pertussis toxin-like subunit ArtA, Subtilase cytotoxin subunit B-like protein | | 著者 | Littler, D.R, Johnson, M.D, Summers, R.J, Schembri, M.A, Rossjohn, J, Beddoe, T. | | 登録日 | 2015-04-10 | | 公開日 | 2016-10-12 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Structure and function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G proteins.
J. Biol. Chem., 2017
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4Z9D
 | | EcPltA | | 分子名称: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Pertussis toxin-like subunit ArtA, SODIUM ION | | 著者 | Littler, D.R, Johnson, M.D, Summers, R.J, Schembri, M.A, Rossjohn, J, Beddoe, T. | | 登録日 | 2015-04-10 | | 公開日 | 2016-10-12 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structure and function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G proteins.
J. Biol. Chem., 2017
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6W9Q
 | | Peptide-bound SARS-CoV-2 Nsp9 RNA-replicase | | 分子名称: | 3C-like proteinase peptide, Non-structural protein 9 fusion, PHOSPHATE ION | | 著者 | Littler, D.R, Gully, B.S, Riboldi-Tunnicliffe, A, Rossjohn, J. | | 登録日 | 2020-03-23 | | 公開日 | 2020-04-08 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9.
Iscience, 23, 2020
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6WC1
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2H6D
 | | Protein Kinase Domain of the Human 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK alpha-2 chain) | | 分子名称: | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | | 著者 | Littler, D.R, Walker, J.R, Wybenga-Groot, L, Newman, E.M, Butler-Cole, C, Mackenzie, F, Finerty, P.J, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | | 登録日 | 2006-05-31 | | 公開日 | 2006-06-27 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | A conserved mechanism of autoinhibition for the AMPK kinase domain: ATP-binding site and catalytic loop refolding as a means of regulation.
Acta Crystallogr.,Sect.F, 66, 2010
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5T3N
 | | Sp-2Cl-cAMPS bound to PKAR CBD2 | | 分子名称: | (2S,4aR,6R,7R,7aS)-6-(6-amino-2-chloro-9H-purin-9-yl)-7-hydroxy-2-sulfanyltetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-2-one, IODIDE ION, cAMP-dependent protein kinase regulatory subunit | | 著者 | Littler, D.R, Gilson, P. | | 登録日 | 2016-08-26 | | 公開日 | 2016-10-12 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Disrupting the Allosteric Interaction between the Plasmodium falciparum cAMP-dependent Kinase and Its Regulatory Subunit.
J. Biol. Chem., 291, 2016
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3KJY
 | | Crystal structure of reduced HOMO SAPIENS CLIC3 | | 分子名称: | Chloride intracellular channel protein 3, SULFATE ION | | 著者 | Littler, D.R, Curmi, P.M.G, Breit, S.N, Perrakis, A. | | 登録日 | 2009-11-04 | | 公開日 | 2009-11-17 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structure of human CLIC3 at 2 A resolution
Proteins, 78, 2010
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7KRI
 | | FR6-bound SARS-CoV-2 Nsp9 RNA-replicase | | 分子名称: | 1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione, MALONATE ION, Non-structural protein 9, ... | | 著者 | Littler, D.R, Gully, B.S, Rossjohn, J. | | 登録日 | 2020-11-20 | | 公開日 | 2021-07-21 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | | 主引用文献 | Binding of a pyrimidine RNA base-mimic to SARS-CoV-2 nonstructural protein 9.
J.Biol.Chem., 297, 2021
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7N3K
 | | Oridonin-bound SARS-CoV-2 Nsp9 | | 分子名称: | (1beta,6beta,7beta,8alpha,9beta,10alpha,13alpha,14R,16beta)-1,6,7,14-tetrahydroxy-7,20-epoxykauran-15-one, Non-structural protein 9, SULFATE ION | | 著者 | Littler, D.R, Gully, B.S, Rossjohn, J. | | 登録日 | 2021-06-01 | | 公開日 | 2021-10-27 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | A natural product compound inhibits coronaviral replication in vitro by binding to the conserved Nsp9 SARS-CoV-2 protein.
J.Biol.Chem., 297, 2021
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2FK9
 | | Human protein kinase C, eta | | 分子名称: | protein kinase C, eta type | | 著者 | Walker, J.R, Littler, D.R, Finerty Jr, P.J, MacKenzie, F, Newman, E.M, Weigelt, J, Sundstrom, M, Arrowsmith, C, Edwards, A, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | | 登録日 | 2006-01-04 | | 公開日 | 2006-01-17 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structure of human protein kinase C eta (PKCeta) C2 domain and identification of phosphorylation sites.
Biochem.Biophys.Res.Commun., 349, 2006
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2YV9
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2YV7
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8DQU
 | | Nanobody bound SARS-CoV-2 Nsp9 | | 分子名称: | Nanobody, Non-structural protein 9 | | 著者 | Littler, D.R, Gully, B.S, Rossjohn, J. | | 登録日 | 2022-07-20 | | 公開日 | 2023-02-08 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.45003176 Å) | | 主引用文献 | Inside-out: Antibody-binding reveals potential folding hinge-points within the SARS-CoV-2 replication co-factor nsp9.
Plos One, 18, 2023
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8SHI
 | | Valpha3S1 Vbeta13S1 HLA C 0602 VRSRRCLRL | | 分子名称: | Beta-2-microglobulin, MHC class I antigen (Fragment), T cell receptor alpha, ... | | 著者 | Littler, D.R, Anand, S, Vivian, J.P, Rossjohn, J. | | 登録日 | 2023-04-14 | | 公開日 | 2023-06-28 | | 最終更新日 | 2023-07-26 | | 実験手法 | X-RAY DIFFRACTION (2.90001726 Å) | | 主引用文献 | Complimentary electrostatics dominate T-cell receptor binding to a psoriasis-associated peptide antigen presented by human leukocyte antigen C∗06:02.
J.Biol.Chem., 299, 2023
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8TUB
 | | HLA B7:02 with HPNGYKSLSTL | | 分子名称: | 1,2-ETHANEDIOL, Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Littler, D.R, Rossjohn, J, Chaurasia, P, Petersen, J. | | 登録日 | 2023-08-16 | | 公開日 | 2024-03-13 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | CD8 + T-cell responses towards conserved influenza B virus epitopes across anatomical sites and age.
Nat Commun, 15, 2024
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8TUH
 | | HLA B7:02 with RPIIRPATL | | 分子名称: | 1,2-ETHANEDIOL, ARG-PRO-ILE-ILE-ARG-PRO-ALA-THR-LEU, Beta-2-microglobulin, ... | | 著者 | Littler, D.R, Rossjohn, J, Chaurasia, P, Petersen, J. | | 登録日 | 2023-08-16 | | 公開日 | 2024-03-13 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.200106 Å) | | 主引用文献 | CD8 + T-cell responses towards conserved influenza B virus epitopes across anatomical sites and age.
Nat Commun, 15, 2024
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8V4Z
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8V50
 | | Crystal structure of a HLA-B*35:01-NP6 with D1 TCR | | 分子名称: | Beta-2-microglobulin, D1 TCR alpha chain, D1 TCR beta chain, ... | | 著者 | Littler, D.R, Rossjohn, J, Gras, S. | | 登録日 | 2023-11-30 | | 公開日 | 2024-12-18 | | 最終更新日 | 2025-02-26 | | 実験手法 | X-RAY DIFFRACTION (2.65001774 Å) | | 主引用文献 | Molecular determinants of cross-strain influenza A virus recognition by alpha beta T cell receptors.
Sci Immunol, 10, 2025
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