3QRG
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![BU of 3qrg by Molmil](/molmil-images/mine/3qrg) | Crystal structure of antiRSVF Fab B21m | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Fab heavy chain Fd fragment, Fab light chain, ... | 著者 | Luo, J, Tsui, P, Lewandowski, F, Spurlino, J, Vecchio, F.D. | 登録日 | 2011-02-17 | 公開日 | 2011-08-10 | 最終更新日 | 2019-12-25 | 実験手法 | X-RAY DIFFRACTION (1.699 Å) | 主引用文献 | Crystal structure anti-RSV Fab B21m To be Published
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2ZEB
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![BU of 2zeb by Molmil](/molmil-images/mine/2zeb) | Potent, Nonpeptide Inhibitors of Human Mast Cell Tryptase | 分子名称: | 1-(1'-{[3-(methylsulfanyl)-2-benzothiophen-1-yl]carbonyl}spiro[1-benzofuran-3,4'-piperidin]-5-yl)methanamine, Tryptase beta 2 | 著者 | Spurlino, J.C, Lewandowski, F, Milligan, C. | 登録日 | 2007-12-08 | 公開日 | 2008-12-09 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives Bioorg.Med.Chem.Lett., 18, 2008
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2ZEC
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![BU of 2zec by Molmil](/molmil-images/mine/2zec) | Potent, Nonpeptide Inhibitors of Human Mast Cell Tryptase | 分子名称: | 1-[1'-(3-phenylacryloyl)spiro[1-benzofuran-3,4'-piperidin]-5-yl]methanamine, Tryptase beta 2 | 著者 | Spurlino, J.C, Lewandowski, F, Milligan, C. | 登録日 | 2007-12-08 | 公開日 | 2008-12-09 | 最終更新日 | 2017-10-11 | 実験手法 | X-RAY DIFFRACTION (2.059 Å) | 主引用文献 | Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives Bioorg.Med.Chem.Lett., 18, 2008
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2ZA5
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![BU of 2za5 by Molmil](/molmil-images/mine/2za5) | Crystal Structure of human tryptase with potent non-peptide inhibitor | 分子名称: | (5-(aminomethyl)-2H-spiro[benzofuran-3,4'-piperidine]-1'-yl)(5-(phenylethynyl)furan-2-yl)methanone, Tryptase beta 2 | 著者 | Spurlino, J.C, Barnakov, S.A, Lewandowski, F, Milligan, C. | 登録日 | 2007-10-02 | 公開日 | 2008-02-26 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives Bioorg.Med.Chem.Lett., 18, 2008
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3PE6
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3C27
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![BU of 3c27 by Molmil](/molmil-images/mine/3c27) | Cyanofluorophenylacetamides as Orally Efficacious Thrombin Inhibitors | 分子名称: | Hirudin-3A, N-[2-(carbamimidamidooxy)ethyl]-2-{6-cyano-3-[(2,2-difluoro-2-pyridin-2-ylethyl)amino]-2-fluorophenyl}acetamide, Thrombin heavy chain, ... | 著者 | Spurlino, J.C, McMillan, M, Lewandowski, F, Milligan, C. | 登録日 | 2008-01-24 | 公開日 | 2009-02-17 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.182 Å) | 主引用文献 | Cyanofluorophenylacetamides as Orally Efficacious Thrombin Inhibitors To be Published
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5UE3
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![BU of 5ue3 by Molmil](/molmil-images/mine/5ue3) | proMMP-9desFnII | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, Matrix metalloproteinase-9, ... | 著者 | Alexander, R.S, Spurlino, J, Milligan, C. | 登録日 | 2016-12-29 | 公開日 | 2017-09-13 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.599 Å) | 主引用文献 | Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation. J. Biol. Chem., 292, 2017
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5UE4
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![BU of 5ue4 by Molmil](/molmil-images/mine/5ue4) | proMMP-9desFnII complexed to JNJ0966 INHIBITOR | 分子名称: | CALCIUM ION, Matrix metalloproteinase-9, SULFATE ION, ... | 著者 | Alexander, R.S, Spurlino, J, Milligan, C. | 登録日 | 2016-12-29 | 公開日 | 2017-09-13 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation. J. Biol. Chem., 292, 2017
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2P7G
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2P7A
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2P7Z
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![BU of 2p7z by Molmil](/molmil-images/mine/2p7z) | |