5UE4
proMMP-9desFnII complexed to JNJ0966 INHIBITOR
Summary for 5UE4
Entry DOI | 10.2210/pdb5ue4/pdb |
Related | 5UE3 |
Descriptor | Matrix metalloproteinase-9, ZINC ION, CALCIUM ION, ... (6 entities in total) |
Functional Keywords | prommp9, zymogen, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Secreted, extracellular space, extracellular matrix : P14780 |
Total number of polymer chains | 2 |
Total formula weight | 54136.11 |
Authors | Alexander, R.S.,Spurlino, J.,Milligan, C. (deposition date: 2016-12-29, release date: 2017-09-13, Last modification date: 2024-03-06) |
Primary citation | Scannevin, R.H.,Alexander, R.,Haarlander, T.M.,Burke, S.L.,Singer, M.,Huo, C.,Zhang, Y.M.,Maguire, D.,Spurlino, J.,Deckman, I.,Carroll, K.I.,Lewandowski, F.,Devine, E.,Dzordzorme, K.,Tounge, B.,Milligan, C.,Bayoumy, S.,Williams, R.,Schalk-Hihi, C.,Leonard, K.,Jackson, P.,Todd, M.,Kuo, L.C.,Rhodes, K.J. Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation. J. Biol. Chem., 292:17963-17974, 2017 Cited by PubMed: 28860188DOI: 10.1074/jbc.M117.806075 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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