2ZA5

Crystal Structure of human tryptase with potent non-peptide inhibitor

Summary for 2ZA5

Entry DOI	10.2210/pdb2za5/pdb
Descriptor	Tryptase beta 2, (5-(aminomethyl)-2H-spiro[benzofuran-3,4'-piperidine]-1'-yl)(5-(phenylethynyl)furan-2-yl)methanone (3 entities in total)
Functional Keywords	tryptase, serine protease, tetramer, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	111615.62
Authors	Spurlino, J.C.,Barnakov, S.A.,Lewandowski, F.,Milligan, C. (deposition date: 2007-10-02, release date: 2008-02-26, Last modification date: 2023-11-01)
Primary citation	Costanzo, M.J.,Yabut, S.C.,Zhang, H.-C.,White, K.B.,de Garavilla, L.,Wang, Y.,Minor, L.K.,Tounge, B.A.,Barnakov, A.N.,Lewandowski, F.,Milligan, C.,Spurlino, J.C.,Abraham, W.M.,Boswell-Smith, V.,Page, C.P.,Maryanoff, B.E. Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives Bioorg.Med.Chem.Lett., 18:2114-2121, 2008 Cited by PubMed: 18272363 DOI: 10.1016/j.bmcl.2008.01.093 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation