3C27

Cyanofluorophenylacetamides as Orally Efficacious Thrombin Inhibitors

Summary for 3C27

• Entry DOI: 10.2210/pdb3c27/pdb
• Related: 2R2M
• Descriptor: Thrombin light chain, Thrombin heavy chain, Hirudin-3A, ... (5 entities in total)
• Functional Keywords: thrombin, serine protease, acute phase, blood coagulation, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, protease, secreted, zymogen, protease inhibitor, serine protease inhibitor, sulfation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Secreted, extracellular space: P00734 P00734; Secreted: P28507
• Total number of polymer chains: 3
• Total formula weight: 34702.56

Authors

Spurlino, J.C.,McMillan, M.,Lewandowski, F.,Milligan, C. (deposition date: 2008-01-24, release date: 2009-02-17, Last modification date: 2011-07-13)

• Primary citation: Kreuter, K.D.,Lee, L.,Lu, T.,Giardino, E.C.,Patel, S.,Haung, H.,Xu, G.,Fitzgerald, M.,Mohan, M.,Crysler, C.,Eisennagel, S.,Dasgupta, M.,McMillan, M.,Spurlino, J.C.,Heubert, N.,Maryanoff, B.E.,Tomczuk, B.E.,Damiano, B.P.,Player, M.R.; Cyanofluorophenylacetamides as Orally Efficacious Thrombin Inhibitors; To be Published,

Experimental method

X-RAY DIFFRACTION (2.182 Å)