3C27

Cyanofluorophenylacetamides as Orally Efficacious Thrombin Inhibitors

Summary for 3C27
Related2R2M
DescriptorThrombin light chain, Thrombin heavy chain, Hirudin-3A, ... (5 entities in total)
Functional Keywordsthrombin, serine protease, acute phase, blood coagulation, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, protease, secreted, zymogen, protease inhibitor, serine protease inhibitor, sulfation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (Human)
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Cellular locationSecreted, extracellular space: P00734 P00734
Secreted: P28507
Total number of polymer chains3
Total formula weight34702.56
Authors
Spurlino, J.C.,McMillan, M.,Lewandowski, F.,Milligan, C. (deposition date: 2008-01-24, release date: 2009-02-17, Last modification date: 2011-07-13)
Primary citationCrysler, C.,Damiano, B.P.,Dasgupta, M.,Eisennagel, S.,Fitzgerald, M.,Giardino, E.C.,Haung, H.,Heubert, N.,Kreuter, K.D.,Lee, L.,Lu, T.,Maryanoff, B.E.,McMillan, M.,Mohan, M.,Patel, S.,Player, M.R.,Spurlino, J.C.,Tomczuk, B.E.,Xu, G.
Cyanofluorophenylacetamides as Orally Efficacious Thrombin Inhibitors
To be Published,
Experimental method
X-RAY DIFFRACTION (2.182 Å)
Structure validation
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PDB entries from 2021-06-16