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8FZQ
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BU of 8fzq by Molmil
Dehosphorylated, ATP-bound human cystic fibrosis transmembrane conductance regulator (CFTR)
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION
著者Levring, J, Terry, D.S, Kilic, Z, Fitzgerald, G.A, Blanchard, S.C, Chen, J.
登録日2023-01-29
公開日2023-03-29
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (4.3 Å)
主引用文献CFTR function, pathology and pharmacology at single-molecule resolution.
Nature, 616, 2023
8UBR
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BU of 8ubr by Molmil
Complex of the phosphorylated human cystic fibrosis transmembrane conductance regulator (CFTR) with CFTRinh-172 and ATP/Mg
分子名称: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 4-[(Z)-{(3M)-4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene}methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Young, P.G, Fiedorczuk, K, Chen, J.
登録日2023-09-24
公開日2024-02-21
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Structural basis for CFTR inhibition by CFTR inh -172.
Proc.Natl.Acad.Sci.USA, 121, 2024
6UY0
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BU of 6uy0 by Molmil
Cryo-EM structure of wild-type bovine multidrug resistance protein 1 (MRP1) under active turnover conditions
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, ...
著者Johnson, Z.L, Chen, J.
登録日2019-11-09
公開日2020-06-10
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.23 Å)
主引用文献Characterization of the kinetic cycle of an ABC transporter by single-molecule and cryo-EM analyses.
Elife, 9, 2020
8GLS
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BU of 8gls by Molmil
Complex of human cystic fibrosis transmembrane conductance regulator (CFTR) and Z1834339853
分子名称: (2S)-1-(3-amino-6-fluoro-1H-indazol-1-yl)-2-methyl-3-phenoxypropan-1-one, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Liu, F, Chen, J.
登録日2023-03-23
公開日2024-06-26
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structure-based discovery of positive and negative CFTR modulators
To Be Published
6O2P
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BU of 6o2p by Molmil
Complex of ivacaftor with cystic fibrosis transmembrane conductance regulator (CFTR)
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, ...
著者Liu, F, Zhang, Z, Chen, J, Levit, A, Shoichet, B.
登録日2019-02-24
公開日2019-06-26
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structural identification of a hotspot on CFTR for potentiation.
Science, 364, 2019
6O1V
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BU of 6o1v by Molmil
Complex of human cystic fibrosis transmembrane conductance regulator (CFTR) and GLPG1837
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, ...
著者Zhang, Z, Liu, F, Chen, J, Levit, A, Shoichet, B.
登録日2019-02-21
公開日2019-06-26
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural identification of a hotspot on CFTR for potentiation.
Science, 364, 2019

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件を2024-11-13に公開中

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