5VHG
| Crystal structure of pentad mutant GAPR-1 | 分子名称: | Golgi-associated plant pathogenesis-related protein 1, SULFATE ION | 著者 | Li, Y, Zhao, Y, Su, M, Chakravarthy, S, Colbert, C.L, Levine, B, Sinha, S.C. | 登録日 | 2017-04-13 | 公開日 | 2017-09-20 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.27 Å) | 主引用文献 | Structural insights into the interaction of the conserved mammalian proteins GAPR-1 and Beclin 1, a key autophagy protein. Acta Crystallogr D Struct Biol, 73, 2017
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2ABO
| NMR structure of gamma herpesvirus 68 a viral Bcl-2 homolog | 分子名称: | bcl-2 homolog | 著者 | Loh, J, Huang, Q, Petros, A.M, Nettesheim, D, van Dyk, L.F, Labrada, L, Speck, S.H, Levine, B, Olejniczak, E.T, Virgin, H.W. | 登録日 | 2005-07-15 | 公開日 | 2006-05-16 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | A surface groove essential for viral Bcl-2 function during chronic infection in vivo. Plos Pathog., 1, 2005
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4W7T
| Crystal Structure of Hsp90-alpha N-domain Bound to the Inhibitor NVP-HSP990 | 分子名称: | (7S)-2-amino-4-methyl-7-phenyl-7,8-dihydroquinazolin-5(6H)-one, Heat shock protein HSP 90-alpha | 著者 | Bellamacina, C.R, Shafer, C.M, Bussiere, D. | 登録日 | 2014-08-22 | 公開日 | 2014-11-26 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Design, Structure-Activity Relationship, and in Vivo Characterization of the Development Candidate NVP-HSP990. J.Med.Chem., 57, 2014
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4U93
| Crystal Structure of Hsp90-alpha N-domain Bound to the Inhibitor NVP-HSP990 | 分子名称: | (7R)-2-amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one, Heat shock protein HSP 90-alpha | 著者 | Bellamacina, C.R, Shafer, C.M, Bussiere, D. | 登録日 | 2014-08-05 | 公開日 | 2014-11-19 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Design, Structure-Activity Relationship, and in Vivo Characterization of the Development Candidate NVP-HSP990. J.Med.Chem., 57, 2014
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5CT7
| BRAF in Complex with RAF265 | 分子名称: | 1-methyl-5-({2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl}oxy)-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine, Serine/threonine-protein kinase B-raf | 著者 | Appleton, B.A. | 登録日 | 2015-07-23 | 公開日 | 2015-09-09 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (3.17 Å) | 主引用文献 | Discovery of RAF265: A Potent mut-B-RAF Inhibitor for the Treatment of Metastatic Melanoma. Acs Med.Chem.Lett., 6, 2015
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4MI8
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3DVU
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5K9L
| Beclin 2 CCD N187L mutant homodimer | 分子名称: | Beclin-2 | 著者 | Su, M, Sinha, S. | 登録日 | 2016-06-01 | 公開日 | 2017-03-08 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | 主引用文献 | BECN2 interacts with ATG14 through a metastable coiled-coil to mediate autophagy. Protein Sci., 26, 2017
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5K7B
| Beclin 2 CCD homodimer | 分子名称: | Beclin-2 | 著者 | Su, M, Sinha, S. | 登録日 | 2016-05-25 | 公開日 | 2017-03-08 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | BECN2 interacts with ATG14 through a metastable coiled-coil to mediate autophagy. Protein Sci., 26, 2017
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8D3Y
| Human alpha3 Na+/K+-ATPase in its exoplasmic side-open state | 分子名称: | FXYD domain-containing ion transport regulator 6, Sodium/potassium-transporting ATPase subunit alpha-3, Sodium/potassium-transporting ATPase subunit beta-1 | 著者 | Nguyen, P.T, Bai, X. | 登録日 | 2022-06-01 | 公開日 | 2022-09-21 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structural basis for gating mechanism of the human sodium-potassium pump. Nat Commun, 13, 2022
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8D3X
| Human alpha3 Na+/K+-ATPase in its K+-occluded state | 分子名称: | FXYD domain-containing ion transport regulator 6, Sodium/potassium-transporting ATPase subunit alpha-3, Sodium/potassium-transporting ATPase subunit beta-1, ... | 著者 | Nguyen, P.T, Bai, X. | 登録日 | 2022-06-01 | 公開日 | 2022-09-21 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structural basis for gating mechanism of the human sodium-potassium pump. Nat Commun, 13, 2022
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8D3U
| Human alpha3 Na+/K+-ATPase in its Na+-occluded state | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, FXYD domain-containing ion transport regulator 6, Sodium/potassium-transporting ATPase subunit alpha-3, ... | 著者 | Nguyen, P.T, Bai, X. | 登録日 | 2022-06-01 | 公開日 | 2022-09-21 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural basis for gating mechanism of the human sodium-potassium pump. Nat Commun, 13, 2022
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8D3W
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8D3V
| Human alpha3 Na+/K+-ATPase in its cytoplasmic side-open state | 分子名称: | FXYD domain-containing ion transport regulator 6, Sodium/potassium-transporting ATPase subunit alpha-3, Sodium/potassium-transporting ATPase subunit beta-1 | 著者 | Nguyen, P.T, Bai, X. | 登録日 | 2022-06-01 | 公開日 | 2022-09-21 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural basis for gating mechanism of the human sodium-potassium pump. Nat Commun, 13, 2022
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6W44
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6W45
| Crystal structure of HAO1 in complex with biaryl acid inhibitor - compound 3 | 分子名称: | 2-chloranyl-4-[2-[[(6-chloranyl-1~{H}-indol-2-yl)carbonyl-methyl-amino]methyl]-5-fluoranyl-phenyl]benzoic acid, FLAVIN MONONUCLEOTIDE, Hydroxyacid oxidase 1 | 著者 | Ferguson, A.D. | 登録日 | 2020-03-10 | 公開日 | 2021-05-12 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening. J.Med.Chem., 64, 2021
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6W4C
| Crystal structure of HAO1 in complex with indazole acid inhibitor - compound 5 | 分子名称: | 5-[[3-[3-(dimethylamino)-1,2,4-oxadiazol-5-yl]-2-oxidanyl-phenyl]methylamino]-2~{H}-indazole-3-carboxylic acid, FLAVIN MONONUCLEOTIDE, Hydroxyacid oxidase 1 | 著者 | Ferguson, A.D. | 登録日 | 2020-03-10 | 公開日 | 2021-05-12 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening. J.Med.Chem., 64, 2021
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