1J56
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![BU of 1j56 by Molmil](/molmil-images/mine/1j56) | MINIMIZED AVERAGE STRUCTURE OF BERYLLOFLUORIDE-ACTIVATED NTRC RECEIVER DOMAIN: MODEL STRUCTURE INCORPORATING ACTIVE SITE CONTACTS | 分子名称: | BERYLLIUM TRIFLUORIDE ION, NITROGEN REGULATION PROTEIN NR(I) | 著者 | Hastings, C.A, Lee, S.-Y, Cho, H.S, Yan, D, Kustu, S, Wemmer, D.E. | 登録日 | 2002-01-10 | 公開日 | 2003-08-19 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | High-Resolution Solution Structure of the Beryllofluoride-Activated NtrC Receiver Domain Biochemistry, 42, 2003
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1KRX
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![BU of 1krx by Molmil](/molmil-images/mine/1krx) | SOLUTION STRUCTURE OF BERYLLOFLUORIDE-ACTIVATED NTRC RECEIVER DOMAIN: MODEL STRUCTURES INCORPORATING ACTIVE SITE CONTACTS | 分子名称: | BERYLLIUM TRIFLUORIDE ION, NITROGEN REGULATION PROTEIN NR(I) | 著者 | Hastings, C.A, Lee, S.-Y, Cho, H.S, Yan, D, Kustu, S, Wemmer, D.E. | 登録日 | 2002-01-10 | 公開日 | 2003-08-19 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | High-Resolution Solution Structure of the Beryllofluoride-Activated NtrC Receiver Domain Biochemistry, 42, 2003
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1KRW
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![BU of 1krw by Molmil](/molmil-images/mine/1krw) | SOLUTION STRUCTURE AND BACKBONE DYNAMICS OF BERYLLOFLUORIDE-ACTIVATED NTRC RECEIVER DOMAIN | 分子名称: | NITROGEN REGULATION PROTEIN NR(I) | 著者 | Hastings, C.A, Lee, S.-Y, Cho, H.S, Yan, D, Kustu, S, Wemmer, D.E. | 登録日 | 2002-01-10 | 公開日 | 2003-08-19 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | High-Resolution Solution Structure of the Beryllofluoride-Activated NtrC Receiver Domain Biochemistry, 42, 2003
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1LLS
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![BU of 1lls by Molmil](/molmil-images/mine/1lls) | CRYSTAL STRUCTURE OF UNLIGANDED MALTOSE BINDING PROTEIN WITH XENON | 分子名称: | Maltose-binding periplasmic protein, XENON | 著者 | Rubin, S.M, Lee, S.-Y, Ruiz, E.J, Pines, A, Wemmer, D.E. | 登録日 | 2002-04-30 | 公開日 | 2002-09-18 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | DETECTION AND CHARACTERIZATION OF XENON-BINDING SITES IN PROTEINS BY 129XE NMR SPECTROSCOPY J.MOL.BIOL., 322, 2002
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1MNL
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![BU of 1mnl by Molmil](/molmil-images/mine/1mnl) | HIGH-RESOLUTION SOLUTION STRUCTURE OF A SWEET PROTEIN SINGLE-CHAIN MONELLIN (SCM) DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND DYNAMICAL SIMULATED ANNEALING CALCULATIONS, 21 STRUCTURES | 分子名称: | MONELLIN | 著者 | Lee, S.-Y, Lee, J.-H, Chang, H.-J, Jo, J.-M, Jung, J.-W, Lee, W. | 登録日 | 1998-08-06 | 公開日 | 1999-06-08 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of a sweet protein single-chain monellin determined by nuclear magnetic resonance and dynamical simulated annealing calculations. Biochemistry, 38, 1999
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6D73
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![BU of 6d73 by Molmil](/molmil-images/mine/6d73) | Cryo-EM structure of the zebrafish TRPM2 channel in the presence of Ca2+ | 分子名称: | CALCIUM ION, Transient receptor potential cation channel, subfamily M | 著者 | Yin, Y, Wu, M, Borschel, W.F, Lander, G.C, Lee, S.-Y. | 登録日 | 2018-04-23 | 公開日 | 2019-05-15 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel. Nat Commun, 10, 2019
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6DT0
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![BU of 6dt0 by Molmil](/molmil-images/mine/6dt0) | Cryo-EM structure of a mitochondrial calcium uniporter | 分子名称: | CALCIUM ION, Mitochondrial calcium uniporter | 著者 | Yoo, J, Wu, M, Yin, Y, Herzik, M.A.J, Lander, G.C, Lee, S.-Y. | 登録日 | 2018-06-14 | 公開日 | 2018-07-11 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Cryo-EM structure of a mitochondrial calcium uniporter. Science, 361, 2018
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9B70
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![BU of 9b70 by Molmil](/molmil-images/mine/9b70) | Cryo-EM structure of MraY in complex with analogue 2 | 分子名称: | (2~{S},3~{S})-3-[(2~{S},3~{R},4~{S},5~{R})-5-(aminomethyl)-3,4-bis(oxidanyl)oxolan-2-yl]oxy-2-[[3-[[[(2~{S})-6-azanyl-2-(hexadecanoylamino)hexanoyl]amino]methyl]phenyl]methylamino]-3-[(2~{S},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]propanoic acid, MraYAA nanobody, Phospho-N-acetylmuramoyl-pentapeptide-transferase | 著者 | Hao, A, Lee, S.-Y. | 登録日 | 2024-03-26 | 公開日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | 主引用文献 | Development of a natural product optimization strategy for inhibitors against MraY, a promising antibacterial target. Nat Commun, 15, 2024
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9B71
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![BU of 9b71 by Molmil](/molmil-images/mine/9b71) | Cryo-EM structure of MraY in complex with analogue 3 | 分子名称: | (2~{S},3~{S})-3-[(2~{S},3~{R},4~{S},5~{R})-5-(aminomethyl)-3,4-bis(oxidanyl)oxolan-2-yl]oxy-3-[(2~{S},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]-2-[[4-[[[(2~{S})-5-carbamimidamido-2-(hexadecanoylamino)pentanoyl]amino]methyl]phenyl]methylamino]propanoic acid, MraYAA Nanobody, Phospho-N-acetylmuramoyl-pentapeptide-transferase | 著者 | Hao, A, Lee, S.-Y. | 登録日 | 2024-03-26 | 公開日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Development of a natural product optimization strategy for inhibitors against MraY, a promising antibacterial target. Nat Commun, 15, 2024
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7RQZ
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![BU of 7rqz by Molmil](/molmil-images/mine/7rqz) | Cryo-EM structure of the full-length TRPV1 with RTx at 48 degrees Celsius, in an open state, class alpha | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate, ... | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | 登録日 | 2021-08-08 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. Nat Commun, 13, 2022
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7RQY
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![BU of 7rqy by Molmil](/molmil-images/mine/7rqy) | Cryo-EM structure of the full-length TRPV1 with RTx at 25 degrees Celsius, in an open state, class B | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate, ... | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | 登録日 | 2021-08-08 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. Nat Commun, 13, 2022
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7RQX
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![BU of 7rqx by Molmil](/molmil-images/mine/7rqx) | Cryo-EM structure of the full-length TRPV1 with RTx at 25 degrees Celsius, in an intermediate-open state, class A | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ... | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | 登録日 | 2021-08-08 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. Nat Commun, 13, 2022
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7RQU
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![BU of 7rqu by Molmil](/molmil-images/mine/7rqu) | Cryo-EM structure of the full-length TRPV1 with RTx at 4 degrees Celsius, in a closed state, class I | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, SODIUM ION, ... | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | 登録日 | 2021-08-08 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. Nat Commun, 13, 2022
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7RQW
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![BU of 7rqw by Molmil](/molmil-images/mine/7rqw) | Cryo-EM structure of the full-length TRPV1 with RTx at 4 degrees Celsius, in an open state, class III | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, ... | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | 登録日 | 2021-08-08 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. Nat Commun, 13, 2022
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7RQV
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![BU of 7rqv by Molmil](/molmil-images/mine/7rqv) | Cryo-EM structure of the full-length TRPV1 with RTx at 4 degrees Celsius, in an intermediate-closed state, class II | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ... | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | 登録日 | 2021-08-08 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. Nat Commun, 13, 2022
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7TX7
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![BU of 7tx7 by Molmil](/molmil-images/mine/7tx7) | |
7TX6
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![BU of 7tx6 by Molmil](/molmil-images/mine/7tx6) | Cryo-EM structure of the human reduced folate carrier in complex with methotrexate | 分子名称: | Digitonin, METHOTREXATE, Reduced folate transporter,Soluble cytochrome b562 | 著者 | Wright, N.J, Fedor, J.G, Lee, S.-Y. | 登録日 | 2022-02-07 | 公開日 | 2022-09-21 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Methotrexate recognition by the human reduced folate carrier SLC19A1. Nature, 609, 2022
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5U9W
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![BU of 5u9w by Molmil](/molmil-images/mine/5u9w) | |
5T77
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![BU of 5t77 by Molmil](/molmil-images/mine/5t77) | Crystal structure of the MOP flippase MurJ | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CALCIUM ION, ... | 著者 | Kuk, A.C.Y, Lee, S.-Y. | 登録日 | 2016-09-02 | 公開日 | 2016-12-28 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of the MOP flippase MurJ in an inward-facing conformation. Nat. Struct. Mol. Biol., 24, 2017
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9B6D
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![BU of 9b6d by Molmil](/molmil-images/mine/9b6d) | Cryo-EM structure of the mouse TRPM8 channel in the ligand-free desensitized state | 分子名称: | CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 8 | 著者 | Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y. | 登録日 | 2024-03-25 | 公開日 | 2024-08-21 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8. Sci Adv, 10, 2024
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9B6I
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![BU of 9b6i by Molmil](/molmil-images/mine/9b6i) | Cryo-EM structure of the avian great tit TRPM8 channel in complex with the antagonist TC-I 2014 | 分子名称: | 3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y. | 登録日 | 2024-03-25 | 公開日 | 2024-08-21 | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | 主引用文献 | Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8. Sci Adv, 10, 2024
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9B6E
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![BU of 9b6e by Molmil](/molmil-images/mine/9b6e) | Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist TC-I 2014 | 分子名称: | 3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene, CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 8 | 著者 | Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y. | 登録日 | 2024-03-25 | 公開日 | 2024-08-21 | 実験手法 | ELECTRON MICROSCOPY (2.91 Å) | 主引用文献 | Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8. Sci Adv, 10, 2024
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9B6F
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![BU of 9b6f by Molmil](/molmil-images/mine/9b6f) | Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist AMG2850 | 分子名称: | (8R)-8-[4-(trifluoromethyl)phenyl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]-5,8-dihydro-1,7-naphthyridine-7(6H)-carboxamide, CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 8 | 著者 | Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y. | 登録日 | 2024-03-25 | 公開日 | 2024-08-21 | 実験手法 | ELECTRON MICROSCOPY (3.42 Å) | 主引用文献 | Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8. Sci Adv, 10, 2024
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9B6G
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![BU of 9b6g by Molmil](/molmil-images/mine/9b6g) | Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist AMTB | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, N-(3-aminopropyl)-2-[(3-methylphenyl)methoxy]-N-[(thiophen-2-yl)methyl]benzamide, ... | 著者 | Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y. | 登録日 | 2024-03-25 | 公開日 | 2024-08-21 | 実験手法 | ELECTRON MICROSCOPY (2.81 Å) | 主引用文献 | Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8. Sci Adv, 10, 2024
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9B6K
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![BU of 9b6k by Molmil](/molmil-images/mine/9b6k) | Cryo-EM structure of the mouse TRPM8 channel in complex with Ca2+ in the absence of PI(4,5)P2 | 分子名称: | CALCIUM ION, Transient receptor potential cation channel subfamily M member 8 | 著者 | Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y. | 登録日 | 2024-03-25 | 公開日 | 2024-08-21 | 実験手法 | ELECTRON MICROSCOPY (4.13 Å) | 主引用文献 | Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8. Sci Adv, 10, 2024
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