7XLP
 
 | | MEK1 bound to DS03090629 | | 分子名称: | (1~{R},3~{S})-3-[[6-[2-chloranyl-4-(4-methylpyrimidin-2-yl)oxy-phenyl]-3-methyl-1~{H}-indazol-4-yl]oxy]cyclohexan-1-amine, CALCIUM ION, DIMETHYL SULFOXIDE, ... | | 著者 | Kishikawa, S, Takano, K, Ubukata, O, Hanzawa, H. | | 登録日 | 2022-04-22 | | 公開日 | 2023-03-01 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Discovery of a Novel ATP-Competitive MEK Inhibitor DS03090629 that Overcomes Resistance Conferred by BRAF Overexpression in BRAF-Mutated Melanoma.
Mol.Cancer Ther., 22, 2023
|
|
7XNC
 | | MEK1 bound to DS94070624 | | 分子名称: | CALCIUM ION, DIMETHYL SULFOXIDE, Dual specificity mitogen-activated protein kinase kinase 1, ... | | 著者 | Kishikawa, S, Takano, K, Ubukata, O, Hanzawa, H. | | 登録日 | 2022-04-28 | | 公開日 | 2023-03-01 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Discovery of a Novel ATP-Competitive MEK Inhibitor DS03090629 that Overcomes Resistance Conferred by BRAF Overexpression in BRAF-Mutated Melanoma.
Mol.Cancer Ther., 22, 2023
|
|
6IF6
 | | Structure of the periplasmic domain of SflA | | 分子名称: | GLYCEROL, PHOSPHATE ION, Protein SflA | | 著者 | Nishikawa, S, Sakuma, M, Kojima, S, Homma, M, Imada, K. | | 登録日 | 2018-09-18 | | 公開日 | 2019-05-01 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structure of the periplasmic domain of SflA involved in spatial regulation of the flagellar biogenesis of Vibrio reveals a TPR/SLR-like fold.
J.Biochem., 166, 2019
|
|
3ZII
 | | Bacillus subtilis SepF G109K, C-terminal domain | | 分子名称: | CELL DIVISION PROTEIN SEPF | | 著者 | Duman, R, Ishikawa, S, Celik, I, Ogasawara, N, Lowe, J, Hamoen, L.W. | | 登録日 | 2013-01-09 | | 公開日 | 2013-11-27 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural and Genetic Analyses Reveal the Protein Sepf as a New Membrane Anchor for the Z Ring.
Proc.Natl.Acad.Sci.USA, 110, 2013
|
|
3WR7
 | | Crystal Structure of Spermidine Acetyltransferase from Escherichia coli | | 分子名称: | COENZYME A, SPERMIDINE, Spermidine N1-acetyltransferase | | 著者 | Sugiyama, S, Ishikawa, S, Tomitori, S, Niiyama, M, Hirose, M, Miyazaki, Y, Higashi, K, Adachi, H, Takano, K, Murakami, S, Inoue, T, Mori, Y, Kashiwagi, K, Igarashi, K, Matsumura, H. | | 登録日 | 2014-02-20 | | 公開日 | 2015-09-02 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Molecular mechanism underlying promiscuous polyamine recognition by spermidine acetyltransferase
Int.J.Biochem.Cell Biol., 76, 2016
|
|
2XXP
 | | A widespread family of bacterial cell wall assembly proteins | | 分子名称: | CPS2A, DI(HYDROXYETHYL)ETHER, MONO-TRANS, ... | | 著者 | Marles-Wright, J, Kawai, Y, Emmins, R, Ishikawa, S, Kuwano, M, Heinz, N, Cleverley, R.M, Bui, N.K, Ogasawara, N, Lewis, R.J, Vollmer, W, Daniel, R.A, Errington, J. | | 登録日 | 2010-11-11 | | 公開日 | 2011-10-19 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.692 Å) | | 主引用文献 | A Widespread Family of Bacterial Cell Wall Assembly Proteins.
Embo J., 30, 2011
|
|
2XXQ
 | | A widespread family of bacterial cell wall assembly proteins | | 分子名称: | (2Z,6Z,10Z,14Z,18Z,22Z,26Z)-3,7,11,15,19,23,27,31-octamethyldotriaconta-2,6,10,14,18,22,26,30-octaen-1-yl trihydrogen diphosphate, 1,2-ETHANEDIOL, ACETATE ION, ... | | 著者 | Marles-Wright, J, Kawai, Y, Emmins, R, Ishikawa, S, Kuwano, M, Heinz, N, Cleverley, R.M, Bui, N.K, Ogasawara, N, Lewis, R.J, Vollmer, W, Daniel, R.A, Errington, J. | | 登録日 | 2010-11-11 | | 公開日 | 2011-10-19 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | | 主引用文献 | A Widespread Family of Bacterial Cell Wall Assembly Proteins.
Embo J., 30, 2011
|
|
3TFL
 | | LytR-Cps2a-Psr family protein with bound octaprenyl pyrophosphate lipid | | 分子名称: | (2Z,6Z,10Z,14Z,18Z,22Z,26Z)-3,7,11,15,19,23,27,31-octamethyldotriaconta-2,6,10,14,18,22,26,30-octaen-1-yl trihydrogen diphosphate, 1,2-ETHANEDIOL, CPS2A, ... | | 著者 | Kawai, Y, Marles-Wright, J, Cleverley, R.M, Emmins, R, Ishikawa, S, Kuwano, M, Heinz, N, Khai Bui, N, Hoyland, C.N, Ogasawara, N, Lewis, R.J, Vollmer, W, Daniel, R.A, Errington, J. | | 登録日 | 2011-08-16 | | 公開日 | 2011-10-12 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | A widespread family of bacterial cell wall assembly proteins.
Embo J., 30, 2011
|
|
3TEP
 | | LytR-CPS2a-Psr family protein with bound octaprenyl pyrophosphate lipid and magnesium ion | | 分子名称: | (2Z,6Z,10Z,14Z,18Z,22Z,26Z)-3,7,11,15,19,23,27,31-octamethyldotriaconta-2,6,10,14,18,22,26,30-octaen-1-yl trihydrogen diphosphate, 1,2-ETHANEDIOL, CPS2A, ... | | 著者 | Kawai, Y, Marles-Wright, J, Cleverley, R.M, Emmins, R, Ishikawa, S, Kuwano, M, Heinz, N, Khai Bui, N, Hoyland, C.N, Ogasawara, N, Lewis, R.J, Vollmer, W, Daniel, R.A, Errington, J. | | 登録日 | 2011-08-15 | | 公開日 | 2011-10-12 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | | 主引用文献 | A widespread family of bacterial cell wall assembly proteins.
Embo J., 30, 2011
|
|
3TEL
 | | LytR-CPS2A-Psr family protein with bound octaprenyl pyrophosphate lipid and manganese ion | | 分子名称: | (2Z,6Z,10Z,14Z,18Z,22Z,26Z)-3,7,11,15,19,23,27,31-octamethyldotriaconta-2,6,10,14,18,22,26,30-octaen-1-yl trihydrogen diphosphate, 1,2-ETHANEDIOL, ACETATE ION, ... | | 著者 | Kawai, Y, Marles-Wright, J, Cleverley, R.M, Emmins, R, Ishikawa, S, Kuwano, M, Heinz, N, Khai Bui, N, Hoyland, C.N, Ogasawara, N, Lewis, R.J, Vollmer, W, Daniel, R.A, Errington, J. | | 登録日 | 2011-08-15 | | 公開日 | 2011-10-12 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | A widespread family of bacterial cell wall assembly proteins.
Embo J., 30, 2011
|
|
3ZIH
 | | Bacillus subtilis SepF, C-terminal domain | | 分子名称: | CELL DIVISION PROTEIN SEPF | | 著者 | Duman, R.E, Ishikawa, S, Celik, I, Ogasawara, N, Lowe, J, Hamoen, L.W. | | 登録日 | 2013-01-09 | | 公開日 | 2013-11-27 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural and Genetic Analyses Reveal the Protein Sepf as a New Membrane Anchor for the Z Ring.
Proc.Natl.Acad.Sci.USA, 110, 2013
|
|
3ZIG
 | | SepF-like protein from Pyrococcus furiosus | | 分子名称: | SEPF-LIKE PROTEIN | | 著者 | Duman, R, Ishikawa, S, Celik, I, Ogasawara, N, Lowe, J, Hamoen, L.W. | | 登録日 | 2013-01-09 | | 公開日 | 2013-11-27 | | 最終更新日 | 2013-12-11 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural and Genetic Analyses Reveal the Protein Sepf as a New Membrane Anchor for the Z Ring.
Proc.Natl.Acad.Sci.USA, 110, 2013
|
|
3ZIE
 | | SepF-like protein from Archaeoglobus fulgidus | | 分子名称: | SEPF-LIKE PROTEIN | | 著者 | Duman, R, Ishikawa, S, Celik, I, Ogasawara, N, Lowe, J, Hamoen, L.W. | | 登録日 | 2013-01-08 | | 公開日 | 2013-11-20 | | 最終更新日 | 2013-12-11 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural and Genetic Analyses Reveal the Protein Sepf as a New Membrane Anchor for the Z Ring
Proc.Natl.Acad.Sci.USA, 110, 2013
|
|
1NBK
 | | The structure of RNA aptamer for HIV Tat complexed with two argininamide molecules | | 分子名称: | 2-AMINO-5-GUANIDINO-PENTANOIC ACID, RNA aptamer | | 著者 | Matsugami, A, Kobayashi, S, Ouhashi, K, Uesugi, S, Yamamoto, R, Taira, K, Nishikawa, S, Kumar, P.K.R, Katahira, M. | | 登録日 | 2002-12-03 | | 公開日 | 2003-12-03 | | 最終更新日 | 2024-09-18 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural Basis of the Highly Efficient Trapping of the HIV Tat Protein by an RNA Aptamer
Structure, 11, 2003
|
|
2RQJ
 | | Quadruplex structure of an RNA aptamer against bovine prion protein | | 分子名称: | RNA (5'-R(*GP*GP*AP*GP*GP*AP*GP*GP*AP*GP*GP*A)-3') | | 著者 | Katahira, M, Mashima, T, Matsugami, A, Nishikawa, F, Nishikawa, S. | | 登録日 | 2009-07-18 | | 公開日 | 2009-11-17 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Unique quadruplex structure and interaction of an RNA aptamer against bovine prion protein
Nucleic Acids Res., 37, 2009
|
|
2RSK
 | | RNA aptamer against prion protein in complex with the partial binding peptide | | 分子名称: | RNA (5'-R(*GP*GP*AP*GP*GP*AP*GP*GP*AP*GP*GP*A)-3'), partial binding peptide of Major prion protein | | 著者 | Mashima, T, Nishikawa, F, Kamatari, Y.O, Fujiwara, H, Nishikawa, S, Kuwata, K, Katahira, M. | | 登録日 | 2012-03-08 | | 公開日 | 2013-02-13 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Anti-prion activity of an RNA aptamer and its structural basis
Nucleic Acids Res., 41, 2013
|
|
1OM2
 | | SOLUTION NMR STRUCTURE OF THE MITOCHONDRIAL PROTEIN IMPORT RECEPTOR TOM20 FROM RAT IN A COMPLEX WITH A PRESEQUENCE PEPTIDE DERIVED FROM RAT ALDEHYDE DEHYDROGENASE (ALDH) | | 分子名称: | PROTEIN (MITOCHONDRIAL ALDEHYDE DEHYDROGENASE), PROTEIN (MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20) | | 著者 | Abe, Y, Shodai, T, Muto, T, Mihara, K, Torii, H, Nishikawa, S, Endo, T, Kohda, D. | | 登録日 | 1999-04-23 | | 公開日 | 2000-02-02 | | 最終更新日 | 2023-12-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20.
Cell(Cambridge,Mass.), 100, 2000
|
|
7WJT
 | |
8JJS
 | | Human K-Ras G12D (GDP-bound) in complex with cyclic peptide inhibitor AP10343 | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, MAA-ILE-SAR-SAR-7T2-SAR-IAE-LEU-MEA-MLE-7TK, ... | | 著者 | Irie, M, Fukami, T.A, Tanada, M, Ohta, A, Torizawa, T. | | 登録日 | 2023-05-31 | | 公開日 | 2023-07-26 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.534 Å) | | 主引用文献 | Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor.
J.Am.Chem.Soc., 145, 2023
|
|
5WPH
 | | Crystal structure of ArsN, N-acetyltransferase with substrate AST from Pseudomonas putida KT2440 | | 分子名称: | (2S)-2-amino-4-[hydroxy(methyl)arsoryl]butanoic acid, Phosphinothricin N-acetyltransferase, SODIUM ION | | 著者 | Venkadesh, S, Dheeman, D.S, Yoshinaga, M, Kandavelu, P, Rosen, B.P. | | 登録日 | 2017-08-04 | | 公開日 | 2018-10-10 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | | 主引用文献 | Arsinothricin, an arsenic-containing non-proteinogenic amino acid analog of glutamate, is a broad-spectrum antibiotic.
Commun Biol, 2, 2019
|
|
5JTF
 | | Crystal structure of ArsN N-acetyltransferase from Pseudomonas putida KT2440 | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Putative Phosphinothricin N-acetyltransferase | | 著者 | Venkadesh, S, Dheeman, D.S, Kandavelu, P, Rosen, B.P. | | 登録日 | 2016-05-09 | | 公開日 | 2017-05-17 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.156 Å) | | 主引用文献 | Arsinothricin, an arsenic-containing non-proteinogenic amino acid analog of glutamate, is a broad-spectrum antibiotic.
Commun Biol, 2, 2019
|
|
7YV1
 | | Human K-Ras G12D (GDP-bound) in complex with cyclic peptide inhibitor LUNA18 and KA30L Fab | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, KA30L Fab H-chain, ... | | 著者 | Irie, M, Fukami, T.A, Matsuo, A, Saka, K, Nishimura, M, Saito, H, Torizawa, T, Tanada, M, Ohta, A. | | 登録日 | 2022-08-18 | | 公開日 | 2023-07-26 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.454 Å) | | 主引用文献 | Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets.
J.Am.Chem.Soc., 145, 2023
|
|
7YUZ
 | | Human K-Ras G12D (GDP-bound) in complex with cyclic peptide inhibitor AP8784 | | 分子名称: | AP8784, GUANOSINE-5'-DIPHOSPHATE, IODIDE ION, ... | | 著者 | Irie, M, Fukami, T.A, Tanada, M, Ohta, A, Torizawa, T. | | 登録日 | 2022-08-18 | | 公開日 | 2023-07-26 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.878 Å) | | 主引用文献 | Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets.
J.Am.Chem.Soc., 145, 2023
|
|
7ZZO
 | | HDAC2 in complex with an inhibitor | | 分子名称: | 2-(cyclohexylazaniumyl)ethanesulfonate, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Cleasby, A, Tisi, D. | | 登録日 | 2022-05-25 | | 公開日 | 2022-09-21 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor.
Acs Med.Chem.Lett., 13, 2022
|
|
7ZZT
 | | Ligand binding to HDAC2 | | 分子名称: | 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, CALCIUM ION, ... | | 著者 | Cleasby, A, Tisi, D. | | 登録日 | 2022-05-26 | | 公開日 | 2022-09-21 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | | 主引用文献 | Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor.
Acs Med.Chem.Lett., 13, 2022
|
|
