2QGH
| Crystal structure of diaminopimelate decarboxylase from Helicobacter pylori complexed with L-lysine | 分子名称: | Diaminopimelate decarboxylase, GLYCEROL, LYSINE, ... | 著者 | Hu, T, Wu, D, Jiang, H, Shen, X. | 登録日 | 2007-06-28 | 公開日 | 2008-05-27 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of diaminopimelate decarboxylase from Helicobacter pylori complexed with L-lysine TO BE PUBLISHED
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3F9G
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3F9E
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3FXO
| Crystal Structure of Human Protein phosphatase 1A (PPM1A) Bound with Phosphate at 1 mM of Mn2+ | 分子名称: | MANGANESE (II) ION, PHOSPHATE ION, Protein phosphatase 1A | 著者 | Hu, T, Wang, L, Wang, K, Jiang, H, Shen, X. | 登録日 | 2009-01-21 | 公開日 | 2010-01-26 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis for the Mn2+-dependent activation of human PPM1A To be published
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3FXM
| Crystal Structure of Human Protein phosphatase 1A (PPM1A) Bound with Citrate at 10 mM of Mn2+ | 分子名称: | CITRATE ANION, MANGANESE (II) ION, PHOSPHATE ION, ... | 著者 | Hu, T, Wang, L, Wang, K, Jiang, H, Shen, X. | 登録日 | 2009-01-21 | 公開日 | 2010-01-26 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis for the Mn2+-dependent activation of human PPM1A To be published
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3FXK
| Crystal Structure of Human Protein phosphatase 1A (PPM1A) Bound with Phosphate at 10 mM of Mn2+ | 分子名称: | MANGANESE (II) ION, PHOSPHATE ION, Protein phosphatase 1A | 著者 | Hu, T, Wang, L, Wang, K, Jiang, H, Shen, X. | 登録日 | 2009-01-21 | 公開日 | 2010-01-26 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural basis for the Mn2+-dependent activation of human PPM1A To be published
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3FXJ
| Crystal Structure of Human Protein phosphatase 1A (PPM1A) Bound with Phosphate at 3 mM of Mn2+ | 分子名称: | MANGANESE (II) ION, PHOSPHATE ION, Protein phosphatase 1A | 著者 | Hu, T, Wang, L, Wang, K, Jiang, H, Shen, X. | 登録日 | 2009-01-21 | 公開日 | 2010-01-26 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis for the Mn2+-dependent activation of human PPM1A To be published
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3FXL
| Crystal Structure of Human Protein phosphatase 1A (PPM1A) Bound with Citrate at 1 mM of Mn2+ | 分子名称: | CITRATE ANION, MANGANESE (II) ION, PHOSPHATE ION, ... | 著者 | Hu, T, Wang, L, Wang, K, Jiang, H, Shen, X. | 登録日 | 2009-01-21 | 公開日 | 2010-01-26 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural basis for the Mn2+-dependent activation of human PPM1A To be published
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3F9F
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3F9H
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4ZIA
| Crystal Structure of STAT3 N-terminal domain | 分子名称: | FORMIC ACID, MAGNESIUM ION, NICKEL (II) ION, ... | 著者 | Hu, T, Chopra, R. | 登録日 | 2015-04-28 | 公開日 | 2015-07-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Impact of the N-Terminal Domain of STAT3 in STAT3-Dependent Transcriptional Activity. Mol.Cell.Biol., 35, 2015
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3C5Q
| Crystal structure of diaminopimelate decarboxylase (I148L mutant) from Helicobacter pylori complexed with L-lysine | 分子名称: | Diaminopimelate decarboxylase, GLYCEROL, LYSINE, ... | 著者 | Hu, T, Wu, D, Jiang, H, Shen, X. | 登録日 | 2008-02-01 | 公開日 | 2008-05-27 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure of diaminopimelate decarboxylase from Helicobacter pylori To be Published
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5CZV
| Crystal structure of Notch3 NRR in complex with 20350 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Fab 20350 heavy chain, ... | 著者 | Hu, T, Fryer, C, Chopra, R, Clark, K. | 登録日 | 2015-08-01 | 公開日 | 2016-06-01 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | 主引用文献 | Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies. Oncogene, 35, 2016
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5CZX
| Crystal structure of Notch3 NRR in complex with 20358 Fab | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 20358 Fab heavy chain, ... | 著者 | Hu, T, Fryer, C, Chopra, R, Clark, K. | 登録日 | 2015-08-01 | 公開日 | 2016-06-01 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies. Oncogene, 35, 2016
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7WNX
| Cryo-EM structure of Mycobacterium smegmatis MmpL3 complexed with ST004 in lipid nanodiscs | 分子名称: | N-[2-(2-adamantylamino)ethyl]-1-[2,4-bis(fluoranyl)phenyl]-5-(4-chlorophenyl)-4-methyl-pyrazole-3-carboxamide, Trehalose monomycolate exporter MmpL3 | 著者 | Zhang, B, Hu, T, Yang, X, Liu, F, Rao, Z. | 登録日 | 2022-01-20 | 公開日 | 2022-08-03 | 最終更新日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | 主引用文献 | Structure-based design of anti-mycobacterial drug leads that target the mycolic acid transporter MmpL3. Structure, 30, 2022
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6EG3
| Crystal structure of human BRM in complex with compound 15 | 分子名称: | 3-[(4-{[(2-chloropyridin-4-yl)carbamoyl]amino}pyridin-2-yl)ethynyl]benzoic acid, ETHANOL, Maltose/maltodextrin-binding periplasmic protein,Probable global transcription activator SNF2L2 | 著者 | Zhu, X, Kulathila, R, Hu, T, Xie, X. | 登録日 | 2018-08-17 | 公開日 | 2018-10-31 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | 主引用文献 | Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. J. Med. Chem., 61, 2018
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6EG2
| Crystal structure of human BRM in complex with compound 16 | 分子名称: | ISOPROPYL ALCOHOL, Maltose/maltodextrin-binding periplasmic protein,Probable global transcription activator SNF2L2, N-(5-amino-2-chloropyridin-4-yl)-N'-(4-bromo-3-{[3-(hydroxymethyl)phenyl]ethynyl}-1,2-thiazol-5-yl)urea | 著者 | Zhu, X, Kulathila, R, Hu, T, Xie, X. | 登録日 | 2018-08-17 | 公開日 | 2018-10-31 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | 主引用文献 | Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. J. Med. Chem., 61, 2018
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2PWX
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2RJG
| Crystal structure of biosynthetic alaine racemase from Escherichia coli | 分子名称: | Alanine racemase, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION | 著者 | Wu, D, Hu, T, Zhang, L, Jiang, H, Shen, X. | 登録日 | 2007-10-15 | 公開日 | 2008-07-08 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis Protein Sci., 17, 2008
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2RJH
| Crystal structure of biosynthetic alaine racemase in D-cycloserine-bound form from Escherichia coli | 分子名称: | Alanine racemase, D-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-N,O-CYCLOSERYLAMIDE, SULFATE ION | 著者 | Wu, D, Hu, T, Zhang, L, Jiang, H, Shen, X. | 登録日 | 2007-10-15 | 公開日 | 2008-07-08 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis Protein Sci., 17, 2008
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5VEB
| Crystal structure of a Fab binding to extracellular domain 5 of Cadherin-6 | 分子名称: | 2-acetamido-2-deoxy-alpha-D-galactopyranose, Cadherin-6, anti-CDH6 Fab heavy chain, ... | 著者 | Zhu, X, Bialucha, C.U, London, A, Clark, K, Hu, T. | 登録日 | 2017-04-04 | 公開日 | 2017-06-07 | 最終更新日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | 主引用文献 | Discovery and Optimization of HKT288, a Cadherin-6-Targeting ADC for the Treatment of Ovarian and Renal Cancers. Cancer Discov, 7, 2017
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3B8W
| Crystal structure of Escherichia coli alaine racemase mutant E221P | 分子名称: | Alanine racemase, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION | 著者 | Wu, D, Hu, T, Zhang, L, Jiang, H, Shen, X. | 登録日 | 2007-11-02 | 公開日 | 2008-07-08 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis Protein Sci., 17, 2008
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3B8V
| Crystal structure of Escherichia coli alaine racemase mutant E221K | 分子名称: | Alanine racemase, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION | 著者 | Wu, D, Hu, T, Zhang, L, Jiang, H, Shen, X. | 登録日 | 2007-11-02 | 公開日 | 2008-07-08 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis Protein Sci., 17, 2008
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3B8T
| Crystal structure of Escherichia coli alaine racemase mutant P219A | 分子名称: | Alanine racemase, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION | 著者 | Wu, D, Hu, T, Zhang, L, Jiang, H, Shen, X. | 登録日 | 2007-11-02 | 公開日 | 2008-07-08 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis Protein Sci., 17, 2008
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3B8U
| Crystal structure of Escherichia coli alaine racemase mutant E221A | 分子名称: | Alanine racemase, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION | 著者 | Wu, D, Hu, T, Zhang, L, Jiang, H, Shen, X. | 登録日 | 2007-11-02 | 公開日 | 2008-07-08 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis Protein Sci., 17, 2008
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