6WQH
 
 | | Molecular basis for the ATPase-powered substrate translocation by the Lon AAA+ protease | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Ig2 substrate, Lon protease, ... | | 著者 | Zhang, K, Li, S, Hsiehb, K, Sub, S, Pintilie, G, Chiu, W, Chang, C. | | 登録日 | 2020-04-28 | | 公開日 | 2021-06-09 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Molecular basis for ATPase-powered substrate translocation by the Lon AAA+ protease.
J.Biol.Chem., 297, 2021
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7YUH
 | | MtaLon-Apo for the spiral oligomers of trimer | | 分子名称: | Lon protease | | 著者 | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | | 登録日 | 2022-08-17 | | 公開日 | 2023-10-25 | | 最終更新日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
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7YUU
 | | MtaLon-ADP for the spiral oligomers of trimer | | 分子名称: | Lon protease | | 著者 | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | | 登録日 | 2022-08-17 | | 公開日 | 2023-10-25 | | 最終更新日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (5.8 Å) | | 主引用文献 | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
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7YUV
 | | MtaLon-ADP for the spiral oligomers of tetramer | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Lon protease | | 著者 | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | | 登録日 | 2022-08-17 | | 公開日 | 2023-10-25 | | 最終更新日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
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7YUP
 | | MtaLon-Apo for the spiral oligomers of pentamer | | 分子名称: | Lon protease | | 著者 | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | | 登録日 | 2022-08-17 | | 公開日 | 2023-10-25 | | 最終更新日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
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7YUT
 | | MtaLon-Apo for the spiral oligomers of hexamer | | 分子名称: | Lon protease | | 著者 | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | | 登録日 | 2022-08-17 | | 公開日 | 2023-10-25 | | 最終更新日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
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7YUX
 | | MtaLon-ADP for the spiral oligomers of hexamer | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Lon protease | | 著者 | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | | 登録日 | 2022-08-18 | | 公開日 | 2023-10-25 | | 最終更新日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
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7YUW
 | | MtaLon-ADP for the spiral oligomers of pentamer | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Lon protease | | 著者 | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | | 登録日 | 2022-08-18 | | 公開日 | 2023-10-25 | | 最終更新日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
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7YUM
 | | MtaLon-Apo for the spiral oligomers of tetramer | | 分子名称: | Lon protease | | 著者 | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | | 登録日 | 2022-08-17 | | 公開日 | 2023-10-25 | | 最終更新日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
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8K93
 | | CryoEM structure of LonC protease S582A open hexamer with lysozyme | | 分子名称: | Endopeptidase La, Monothiophosphate | | 著者 | Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S. | | 登録日 | 2023-07-31 | | 公開日 | 2024-08-07 | | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | | 主引用文献 | Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis
Fundam Res, 2024
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8K96
 | | CryoEM structure of LonC protease hepatmer with Bortezomib | | 分子名称: | N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE, PHOSPHATE ION, endopeptidase La | | 著者 | Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S. | | 登録日 | 2023-07-31 | | 公開日 | 2024-08-07 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | | 主引用文献 | Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis
Fundam Res, 2024
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8K97
 | | CryoEM structure of LonC protease hexamer with Bortezomib | | 分子名称: | N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE, PHOSPHATE ION, endopeptidase La | | 著者 | Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S. | | 登録日 | 2023-07-31 | | 公開日 | 2024-08-07 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (2.73 Å) | | 主引用文献 | Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis
Fundam Res, 2024
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8K8Y
 | | CryoEM structure of LonC heptamer in presence of AGS | | 分子名称: | Monothiophosphate, endopeptidase La | | 著者 | Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S. | | 登録日 | 2023-07-31 | | 公開日 | 2024-08-07 | | 実験手法 | ELECTRON MICROSCOPY (2.54 Å) | | 主引用文献 | Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis
Fundam Res, 2024
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8K8X
 | | CryoEM of LonC open pentamer, apo state | | 分子名称: | endopeptidase La | | 著者 | Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S. | | 登録日 | 2023-07-31 | | 公開日 | 2024-08-07 | | 実験手法 | ELECTRON MICROSCOPY (3.53 Å) | | 主引用文献 | Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis
Fundam Res, 2024
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8K92
 | | CryoEM structure of LonC S582A hexamer with Lysozyme | | 分子名称: | Endopeptidase La, Monothiophosphate | | 著者 | Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S. | | 登録日 | 2023-07-31 | | 公開日 | 2024-08-07 | | 実験手法 | ELECTRON MICROSCOPY (3.31 Å) | | 主引用文献 | Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis
Fundam Res, 2024
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8K90
 | | CryoEM structure of LonC protease open pentamer in presence of AGS | | 分子名称: | Monothiophosphate, endopeptidase La | | 著者 | Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S. | | 登録日 | 2023-07-31 | | 公開日 | 2024-08-07 | | 実験手法 | ELECTRON MICROSCOPY (3.43 Å) | | 主引用文献 | Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis
Fundam Res, 2024
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8K8V
 | | CryoEM structure of LonC protease hepatmer, apo state | | 分子名称: | PHOSPHATE ION, endopeptidase La | | 著者 | Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S. | | 登録日 | 2023-07-31 | | 公開日 | 2024-08-07 | | 実験手法 | ELECTRON MICROSCOPY (2.75 Å) | | 主引用文献 | Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis
Fundam Res, 2024
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8K8Z
 | | CryoEM structure of LonC protease hexamer in presence of AGS | | 分子名称: | Monothiophosphate, endopeptidase La | | 著者 | Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S. | | 登録日 | 2023-07-31 | | 公開日 | 2024-08-07 | | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | | 主引用文献 | Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis
Fundam Res, 2024
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8K91
 | | CryoEM structure of LonC S582A hepatmer with Lysozyme | | 分子名称: | Endopeptidase La, Monothiophosphate | | 著者 | Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S. | | 登録日 | 2023-07-31 | | 公開日 | 2024-08-07 | | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | | 主引用文献 | Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis
Fundam Res, 2024
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8K95
 | | CryoEM structure of LonC protease open Hexamer, AGS | | 分子名称: | Monothiophosphate, endopeptidase La | | 著者 | Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S. | | 登録日 | 2023-07-31 | | 公開日 | 2024-08-07 | | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | | 主引用文献 | Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis
Fundam Res, 2024
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8K94
 | | CryoEM structure of LonC protease S582A open pentamer with lysozyme | | 分子名称: | Endopeptidase La, Monothiophosphate | | 著者 | Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S. | | 登録日 | 2023-07-31 | | 公開日 | 2024-08-07 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis
Fundam Res, 2024
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8K8W
 | | CryoEM structure of LonC protease open hexamer, apo state | | 分子名称: | endopeptidase La | | 著者 | Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S. | | 登録日 | 2023-07-31 | | 公開日 | 2024-08-07 | | 実験手法 | ELECTRON MICROSCOPY (3.46 Å) | | 主引用文献 | Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis
Fundam Res, 2024
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7FID
 | | Processive cleavage of substrate at individual proteolytic active sites of the Lon proteasecomplex (conformation 1) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | | 著者 | Li, S, Hsieh, K, Kuo, C, Su, S, Huang, K, Zhang, K, Chang, C.I. | | 登録日 | 2021-07-31 | | 公開日 | 2021-11-24 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (2.44 Å) | | 主引用文献 | Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex.
Sci Adv, 7, 2021
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7FIZ
 | | Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex (conformation 3) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | | 著者 | Li, S, Hsieh, K, Kuo, C, Su, S, Huang, K, Zhang, K, Chang, C.I. | | 登録日 | 2021-08-01 | | 公開日 | 2021-11-24 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.28 Å) | | 主引用文献 | Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex.
Sci Adv, 7, 2021
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7FIE
 | | Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex (conformation 2) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | | 著者 | Li, S, Hsieh, K, Kuo, C, Su, S, Huang, K, Zhang, K, Chang, C.I. | | 登録日 | 2021-07-31 | | 公開日 | 2021-11-24 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (2.36 Å) | | 主引用文献 | Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex.
Sci Adv, 7, 2021
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