8CIL
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4WV7
| HEAT SHOCK PROTEIN 70 SUBSTRATE BINDING DOMAIN WITH COVALENTLY LINKED NOVOLACTONE | 分子名称: | (5beta,6alpha,8alpha,14alpha)-13-ethenyl-5,6-dihydroxy-14-methylpodocarp-12-en-15-oic acid, Heat shock 70 kDa protein 1A/1B | 著者 | Kirby, C.A, Baird, J, Stams, T. | 登録日 | 2014-11-04 | 公開日 | 2015-01-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | 主引用文献 | The novolactone natural product disrupts the allosteric regulation of hsp70. Chem.Biol., 22, 2015
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4WV5
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4FN5
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5CS2
| Crystal structure of Plasmodium falciparum diadenosine triphosphate hydrolase in complex with Cyclomarin A | 分子名称: | CHLORIDE ION, Cyclomarin A, Histidine triad protein | 著者 | Ostermann, N, Schmitt, E, Gerhartz, B, Hinniger, A, Delmas, C. | 登録日 | 2015-07-23 | 公開日 | 2015-10-28 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Gift from Nature: Cyclomarin A Kills Mycobacteria and Malaria Parasites by Distinct Modes of Action. Chembiochem, 16, 2015
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6F0E
| Structure of yeast Sec14p with a picolinamide compound | 分子名称: | SEC14 cytosolic factor, ~{N}-(1,3-benzodioxol-5-ylmethyl)-5-bromanyl-3-fluoranyl-pyridine-2-carboxamide | 著者 | Hong, Z, Johnen, P, Schaaf, G, Bono, F. | 登録日 | 2017-11-20 | 公開日 | 2018-01-17 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Target Identification and Mechanism of Action of Picolinamide and Benzamide Chemotypes with Antifungal Properties. Cell Chem Biol, 25, 2018
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8DO3
| Cryo-EM structure of the human Sec61 complex inhibited by eeyarestatin I | 分子名称: | N'-(4-chlorophenyl)-N-[(4R)-3-(4-chlorophenyl)-5,5-dimethyl-1-(2-{(2E)-2-[(2E)-3-(5-nitrofuran-2-yl)prop-2-en-1-ylidene]hydrazinyl}-2-oxoethyl)-2-oxoimidazolidin-4-yl]-N-hydroxyurea, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... | 著者 | Park, E, Itskanov, S. | 登録日 | 2022-07-12 | 公開日 | 2023-05-24 | 最終更新日 | 2023-09-06 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
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8DNV
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8DNW
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8DO0
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8DO1
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8DO2
| Cryo-EM structure of the human Sec61 complex inhibited by cyclotriazadisulfonamide (CADA) | 分子名称: | 9-benzyl-1,5-bis(4-methylbenzene-1-sulfonyl)-3-methylidene-1,5,9-triazacyclododecane, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... | 著者 | Park, E, Itskanov, S. | 登録日 | 2022-07-12 | 公開日 | 2023-05-24 | 最終更新日 | 2023-09-06 | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | 主引用文献 | A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
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8DNY
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8DNZ
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8DNX
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