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4JVH
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BU of 4jvh by Molmil
Structure of the star domain of quaking protein in complex with RNA
分子名称: Protein quaking, RNA (5'-R(*UP*UP*CP*AP*CP*UP*AP*AP*CP*AP*A)-3'), SULFATE ION
著者Teplova, M, Hafner, M, Teplov, D, Essig, K, Tuschl, T, Patel, D.J.
登録日2013-03-25
公開日2013-05-08
実験手法X-RAY DIFFRACTION (3.501 Å)
主引用文献Structure-function studies of STAR family Quaking proteins bound to their in vivo RNA target sites.
Genes Dev., 27, 2013
4JVY
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BU of 4jvy by Molmil
Structure of the STAR (signal transduction and activation of RNA) domain of GLD-1 bound to RNA
分子名称: Female germline-specific tumor suppressor gld-1, RNA (5'-R(P*CP*UP*AP*AP*CP*AP*A)-3')
著者Teplova, M, Hafner, M, Teplov, D, Essig, K, Tuschl, T, Patel, D.J.
登録日2013-03-26
公開日2013-05-08
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.853 Å)
主引用文献Structure-function studies of STAR family Quaking proteins bound to their in vivo RNA target sites.
Genes Dev., 27, 2013
4EOW
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BU of 4eow by Molmil
Crystal structure of a disease-associated anti-human GM-CSF autoantibody MB007
分子名称: MB007 IgG1 Fab fragment light chain, MB007 human IgG1 Fab fragment heavy chain
著者Blech, M.
登録日2012-04-16
公開日2012-08-22
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Molecular structure of human GM-CSF in complex with a disease-associated anti-human GM-CSF autoantibody and its potential biological implications.
Biochem.J., 447, 2012
7TYQ
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BU of 7tyq by Molmil
TEAD2 bound to Compound 1
分子名称: Transcriptional enhancer factor TEF-4, ethyl (8S)-7-oxo-5-[4-(trifluoromethyl)phenyl]-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylate
著者Noland, C.L, Fong, R.
登録日2022-02-14
公開日2023-05-03
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Novel mechanism of YAP-TEAD inhibition results in targeted chromatin remodeling and reveals an expanded Hippo dependent landscape in cancers
To Be Published
7TYU
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BU of 7tyu by Molmil
TEAD2 bound to Compound 2
分子名称: (3R)-1-[(8S)-5-(4-cyclohexylphenyl)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonyl]pyrrolidine-3-carbonitrile, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Transcriptional enhancer factor TEF-4
著者Noland, C.L, Fong, R.
登録日2022-02-14
公開日2023-05-03
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Novel mechanism of YAP-TEAD inhibition results in targeted chromatin remodeling and reveals an expanded Hippo dependent landscape in cancers
To Be Published
7TYP
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BU of 7typ by Molmil
TEAD2 bound to GNE-7883
分子名称: (8S)-5-(4-cyclohexylphenyl)-3-[3-(fluoromethyl)azetidine-1-carbonyl]-2-(3-methylpyrazin-2-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Transcriptional enhancer factor TEF-4
著者Noland, C.L, Fong, R.
登録日2022-02-14
公開日2023-05-03
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Novel mechanism of YAP-TEAD inhibition results in targeted chromatin remodeling and reveals an expanded Hippo dependent landscape in cancers
To Be Published
8V1H
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BU of 8v1h by Molmil
Crystal structure of human pre-mascRNA
分子名称: SODIUM ION, pre-mascRNA
著者Skeparnias, I, Zhang, J.
登録日2023-11-20
公開日2024-07-10
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献Structural basis of MALAT1 RNA maturation and mascRNA biogenesis
Nat.Struct.Mol.Biol., 2024
8V1I
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BU of 8v1i by Molmil
Crystal structure of human mascRNA
分子名称: 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ...
著者Skeparnias, I, Zhang, J.
登録日2023-11-20
公開日2024-07-10
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis of MALAT1 RNA maturation and mascRNA biogenesis
Nat.Struct.Mol.Biol., 2024
6OQI
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BU of 6oqi by Molmil
CDK2 in complex with Cpd14 (5-fluoro-4-(4-methyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a]azepin-3-yl)-N-(5-(4-methylpiperazin-1-yl)pyridin-2-yl)pyrimidin-2-amine)
分子名称: 5-fluoro-N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]-4-[(4S)-4-methyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a]azepin-3-yl]pyrimidin-2-amine, Cyclin-dependent kinase 2
著者Murray, J.M.
登録日2019-04-26
公開日2020-07-29
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma.
Bioorg.Med.Chem.Lett., 29, 2019
6OQO
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BU of 6oqo by Molmil
CDK6 in complex with Cpd24 N-(5-(6-ethyl-2,6-diazaspiro[3.3]heptan-2-yl)pyridin-2-yl)-5-fluoro-4-(4-methyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a]azepin-3-yl)pyrimidin-2-amine
分子名称: Cyclin-dependent kinase 6, N-[5-(6-ethyl-2,6-diazaspiro[3.3]heptan-2-yl)pyridin-2-yl]-5-fluoro-4-[(4R)-4-methyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a]azepin-3-yl]pyrimidin-2-amine
著者Murray, J.M, Boenig, G.D.L.
登録日2019-04-26
公開日2020-07-29
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.977 Å)
主引用文献Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma.
Bioorg.Med.Chem.Lett., 29, 2019
6OQL
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BU of 6oql by Molmil
CDK6 in complex with Cpd13 (R)-5-fluoro-4-(4-methyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a]azepin-3-yl)-N-(5-(4-methylpiperazin-1-yl)pyridin-2-yl)pyrimidin-2-amine
分子名称: 5-fluoro-N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]-4-[(4R)-4-methyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a]azepin-3-yl]pyrimidin-2-amine, Cyclin-dependent kinase 6
著者Murray, J.M.
登録日2019-04-26
公開日2020-07-29
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.707 Å)
主引用文献Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma.
Bioorg.Med.Chem.Lett., 29, 2019
8QU5
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mt-LSU assembly intermediate in GTPBP8 knock-out cells, state 2
分子名称: 16S ribosomal RNA, 39S ribosomal protein L10, mitochondrial, ...
著者Valentin Gese, G, Cipullo, M, Rorbach, J, Hallberg, B.M.
登録日2023-10-13
公開日2024-06-26
実験手法ELECTRON MICROSCOPY (2.42 Å)
主引用文献GTPBP8 plays a role in mitoribosome formation in human mitochondria
Nat Commun, 2024
8QRM
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BU of 8qrm by Molmil
mt-SSU assembly intermediate in GTPBP8 knock-out cells, state 3
分子名称: 12S mitochondrial rRNA, 28S ribosomal protein S10, mitochondrial, ...
著者Valentin Gese, G, Cipullo, M, Rorbach, J, Hallberg, B.M.
登録日2023-10-09
公開日2024-06-26
実験手法ELECTRON MICROSCOPY (3.05 Å)
主引用文献GTPBP8 plays a role in mitoribosome formation in human mitochondria
Nat Commun, 2024
8QRK
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BU of 8qrk by Molmil
mt-SSU assembly intermediate in GTPBP8 knock-out cells, state 1
分子名称: 12S mitochondrial rRNA, 28S ribosomal protein S10, mitochondrial, ...
著者Valentin Gese, G, Cipullo, M, Rorbach, J, Hallberg, B.M.
登録日2023-10-09
公開日2024-06-26
実験手法ELECTRON MICROSCOPY (6.69 Å)
主引用文献GTPBP8 is essential for mitoribosome formation in human mitochondria
Nat Commun, 2024
8QRN
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BU of 8qrn by Molmil
mt-SSU in GTPBP8 knock-out cells, state 4
分子名称: 12S mitochondrial rRNA, 28S ribosomal protein S10, mitochondrial, ...
著者Valentin Gese, G, Cipullo, M, Rorbach, J, Hallberg, B.M.
登録日2023-10-09
公開日2024-06-26
実験手法ELECTRON MICROSCOPY (2.98 Å)
主引用文献GTPBP8 plays a role in mitoribosome formation in human mitochondria
Nat Commun, 2024
8QRL
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BU of 8qrl by Molmil
mt-SSU assembly intermediate in GTPBP8 knock-out cells, state 2
分子名称: 12S mitochondrial rRNA, 12S rRNA N4-methylcytidine (m4C) methyltransferase, 28S ribosomal protein S10, ...
著者Valentin Gese, G, Cipullo, M, Rorbach, J, Hallberg, B.M.
登録日2023-10-09
公開日2024-06-26
実験手法ELECTRON MICROSCOPY (3.34 Å)
主引用文献GTPBP8 is essential for mitoribosome formation in human mitochondria
Nat Commun, 2024
8QU1
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BU of 8qu1 by Molmil
mt-LSU assembly intermediate in GTPBP8 knock-out cells, state 1
分子名称: 16S ribosomal RNA, 39S ribosomal protein L10, mitochondrial, ...
著者Valentin Gese, G, Cipullo, M, Rorbach, J, Hallberg, B.M.
登録日2023-10-13
公開日2024-06-26
実験手法ELECTRON MICROSCOPY (2.74 Å)
主引用文献GTPBP8 plays a role in mitoribosome formation in human mitochondria
Nat Commun, 2024
4G6J
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BU of 4g6j by Molmil
Crystal structure of human IL-1beta in complex with the therapeutic antibody binding fragment of canakinumab
分子名称: Interleukin-1 beta, heavy chain of antibody binding fragment of canakinumab, light chain of antibody binding fragment of canakinumab
著者Blech, M, Hoerer, S.
登録日2012-07-19
公開日2012-12-19
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献One traget-two different binding modes: Structural insights into gevokizumab and canakinumab interactions to interleukin-1beta
J.Mol.Biol., 425, 2013
4G5Z
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BU of 4g5z by Molmil
Crystal structure of the therapeutical antibody fragment of canakinumab in its unbound state
分子名称: canakinumab antibody fragment heavy chain, canakinumab antibody fragment light chain
著者Blech, M, Hoerer, S.
登録日2012-07-18
公開日2012-12-19
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献One target-two different binding modes: Structural insights into gevokizumab and canakinumab interactions to interleukin-1beta
J.Mol.Biol., 425, 2013
4G6M
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BU of 4g6m by Molmil
Crystal structure of human IL-1beta in complex with therapeutic antibody binding fragment of gevokizumab
分子名称: Interleukin-1 beta, heavy chain of gevokizumab antibody binding fragment, light chain of gevokizumab antibody binding fragment
著者Blech, M, Hoerer, S.
登録日2012-07-19
公開日2012-12-19
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Crystal structure of human IL-1beta in complex with therapeutic antibody binding fragment of gevokizumab
J.Mol.Biol., 425, 2013
4G6K
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BU of 4g6k by Molmil
Crystal structure of the therapeutic antibody binding fragment of gevokizumab in its unbound state
分子名称: heavy chain of gevokizumab antibody binding fragment, light chain of gevokizumab antibody binding fragment
著者Blech, M, Hoerer, S.
登録日2012-07-19
公開日2012-12-19
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献One target-two different binding modes: Structural insights into gevokizumab and canakinumab interactions to interleukin-1beta
J.Mol.Biol., 425, 2013

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件を2024-07-10に公開中

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