5U8T
| Structure of Eukaryotic CMG Helicase at a Replication Fork and Implications | 分子名称: | Cell division control protein 45, DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), DNA replication complex GINS protein PSF1, ... | 著者 | Li, B, Georgescu, R, Yuan, Z, Santos, R, Sun, J, Zhang, D, Yurieva, O, Li, H, O'Donnell, M.E. | 登録日 | 2016-12-15 | 公開日 | 2017-02-08 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | 主引用文献 | Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5U8S
| Structure of eukaryotic CMG helicase at a replication fork | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, DNA (26-MER), ... | 著者 | Li, H, Li, B, Georgescu, R, Yuan, Z, Santos, R, Sun, J, Zhang, D, Yurieva, O, O'Donnell, M.E. | 登録日 | 2016-12-14 | 公開日 | 2017-01-25 | 最終更新日 | 2020-01-01 | 実験手法 | ELECTRON MICROSCOPY (6.101 Å) | 主引用文献 | Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6WJV
| Structure of the Saccharomyces cerevisiae polymerase epsilon holoenzyme | 分子名称: | DNA polymerase epsilon catalytic subunit A, DNA polymerase epsilon subunit B, DNA polymerase epsilon subunit C, ... | 著者 | Yuan, Z, Georgescu, R, Schauer, G.D, O'Donnell, M, Li, H. | 登録日 | 2020-04-14 | 公開日 | 2020-07-08 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structure of the polymerase epsilon holoenzyme and atomic model of the leading strand replisome. Nat Commun, 11, 2020
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6U0M
| Structure of the S. cerevisiae replicative helicase CMG in complex with a forked DNA | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, DNA (15-MER), ... | 著者 | Yuan, Z, Georgescu, R, Bai, L, Zhang, D, O'Donnell, M, Li, H. | 登録日 | 2019-08-14 | 公開日 | 2020-03-25 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | DNA unwinding mechanism of a eukaryotic replicative CMG helicase. Nat Commun, 11, 2020
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6PTO
| Structure of Ctf4 trimer in complex with three CMG helicases | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, DNA polymerase alpha-binding protein, ... | 著者 | Yuan, Z, Georgescu, R, Bai, L, Santos, R, Donnell, M, Li, H. | 登録日 | 2019-07-16 | 公開日 | 2019-11-20 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (7 Å) | 主引用文献 | Ctf4 organizes sister replisomes and Pol alpha into a replication factory. Elife, 8, 2019
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6PTJ
| Structure of Ctf4 trimer in complex with one CMG helicase | 分子名称: | Cell division control protein 45, DNA polymerase alpha-binding protein, DNA replication complex GINS protein PSF1, ... | 著者 | Yuan, Z, Georgescu, R, Bai, L, Santos, R, Donnell, M, Li, H. | 登録日 | 2019-07-15 | 公開日 | 2019-11-20 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Ctf4 organizes sister replisomes and Pol alpha into a replication factory. Elife, 8, 2019
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6PTN
| Structure of Ctf4 trimer in complex with two CMG helicases | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, DNA polymerase alpha-binding protein, ... | 著者 | Yuan, Z, Georgescu, R, Bai, L, Santos, R, Donnell, M, Li, H. | 登録日 | 2019-07-16 | 公開日 | 2019-11-20 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (5.8 Å) | 主引用文献 | Ctf4 organizes sister replisomes and Pol alpha into a replication factory. Elife, 8, 2019
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8FOJ
| Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in the post RNA handoff state | 分子名称: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | 著者 | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | 登録日 | 2022-12-30 | 公開日 | 2023-05-31 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
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8FOH
| Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in the RNA synthesis state | 分子名称: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | 著者 | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | 登録日 | 2022-12-30 | 公開日 | 2023-05-31 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | 主引用文献 | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
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8FOC
| Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase in Apo state conformation I | 分子名称: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | 著者 | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | 登録日 | 2022-12-30 | 公開日 | 2023-05-31 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
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8FOE
| Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex bound to a template DNA | 分子名称: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | 著者 | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | 登録日 | 2022-12-30 | 公開日 | 2023-05-31 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (5.6 Å) | 主引用文献 | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
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8FOK
| Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in the DNA elongation state | 分子名称: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | 著者 | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | 登録日 | 2022-12-30 | 公開日 | 2023-05-31 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.56 Å) | 主引用文献 | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
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8FOD
| Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in Apo state conformation II | 分子名称: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | 著者 | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | 登録日 | 2022-12-30 | 公開日 | 2023-05-31 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
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7TFL
| Atomic model of S. cerevisiae clamp loader RFC bound to DNA | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | 著者 | Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H. | 登録日 | 2022-01-06 | 公開日 | 2022-11-16 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.33 Å) | 主引用文献 | Cryo-EM structures reveal that RFC recognizes both the 3'- and 5'-DNA ends to load PCNA onto gaps for DNA repair. Elife, 11, 2022
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7TFI
| Atomic model of the S. cerevisiae clamp-clamp loader complex PCNA-RFC bound to DNA with an open clamp | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | 著者 | Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H. | 登録日 | 2022-01-06 | 公開日 | 2022-11-16 | 実験手法 | ELECTRON MICROSCOPY (3.41 Å) | 主引用文献 | Cryo-EM structures reveal that RFC recognizes both the 3'- and 5'-DNA ends to load PCNA onto gaps for DNA repair. Elife, 11, 2022
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7TFH
| Atomic model of the S. cerevisiae clamp-clamp loader complex PCNA-RFC bound to two DNA molecules, one at the 5'-recessed end and the other at the 3'-recessed end | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | 著者 | Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H. | 登録日 | 2022-01-06 | 公開日 | 2022-11-16 | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | 主引用文献 | Cryo-EM structures reveal that RFC recognizes both the 3'- and 5'-DNA ends to load PCNA onto gaps for DNA repair. Elife, 11, 2022
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7TFJ
| Atomic model of S. cerevisiae clamp-clamp loader complex PCNA-RFC bound to DNA with a closed clamp ring | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | 著者 | Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H. | 登録日 | 2022-01-06 | 公開日 | 2022-11-16 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Cryo-EM structures reveal that RFC recognizes both the 3'- and 5'-DNA ends to load PCNA onto gaps for DNA repair. Elife, 11, 2022
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7TFK
| Atomic model of S. cerevisiae clamp loader RFC bound to two DNA molecules, one at the 5'-recessed end and the other at the 3'-recessed end | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | 著者 | Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H. | 登録日 | 2022-01-06 | 公開日 | 2022-11-16 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | 主引用文献 | Cryo-EM structures reveal that RFC recognizes both the 3'- and 5'-DNA ends to load PCNA onto gaps for DNA repair. Elife, 11, 2022
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8THD
| Structure of the Saccharomyces cerevisiae clamp unloader Elg1-RFC bound to PCNA | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ELG1 isoform 1, MAGNESIUM ION, ... | 著者 | Zheng, F, Yao, Y.N, Georgescu, R, O'Donnell, M.E, Li, H. | 登録日 | 2023-07-14 | 公開日 | 2024-05-22 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | 主引用文献 | Structure of the PCNA unloader Elg1-RFC. Sci Adv, 10, 2024
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7SGZ
| Structure of the yeast Rad24-RFC loader bound to DNA and the closed 9-1-1 clamp | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Checkpoint protein RAD24, Crick strand, ... | 著者 | Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H. | 登録日 | 2021-10-07 | 公開日 | 2022-03-23 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.17 Å) | 主引用文献 | DNA is loaded through the 9-1-1 DNA checkpoint clamp in the opposite direction of the PCNA clamp. Nat.Struct.Mol.Biol., 29, 2022
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7SH2
| Structure of the yeast Rad24-RFC loader bound to DNA and the open 9-1-1 clamp | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Checkpoint protein RAD24, Crick strand, ... | 著者 | Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H. | 登録日 | 2021-10-07 | 公開日 | 2022-03-23 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | 主引用文献 | DNA is loaded through the 9-1-1 DNA checkpoint clamp in the opposite direction of the PCNA clamp. Nat.Struct.Mol.Biol., 29, 2022
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7KC0
| Structure of the Saccharomyces cerevisiae replicative polymerase delta in complex with a primer/template and the PCNA clamp | 分子名称: | 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, DNA (25-MER), DNA (5'-D(P*AP*TP*GP*AP*CP*CP*AP*TP*GP*AP*TP*TP*AP*CP*GP*AP*AP*TP*TP*GP*C)-3'), ... | 著者 | Zheng, F, Georgescu, R, Li, H, O'Donnell, M.E. | 登録日 | 2020-10-04 | 公開日 | 2020-12-02 | 最終更新日 | 2020-12-16 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structure of eukaryotic DNA polymerase delta bound to the PCNA clamp while encircling DNA. Proc.Natl.Acad.Sci.USA, 117, 2020
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8THB
| Structure of the Saccharomyces cerevisiae PCNA clamp unloader Elg1-RFC complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ELG1 isoform 1, MAGNESIUM ION, ... | 著者 | Zheng, F, Yao, Y.N, Georgescu, R, O'Donnell, M.E, Li, H. | 登録日 | 2023-07-14 | 公開日 | 2024-05-22 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structure of the PCNA unloader Elg1-RFC. Sci Adv, 10, 2024
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8THC
| Structure of the Saccharomyces cerevisiae clamp unloader Elg1-RFC bound to a cracked PCNA | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ELG1 isoform 1, MAGNESIUM ION, ... | 著者 | Zheng, F, Yao, Y.N, Georgescu, R, O'Donnell, M.E, Li, H. | 登録日 | 2023-07-14 | 公開日 | 2024-05-22 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.67 Å) | 主引用文献 | Structure of the PCNA unloader Elg1-RFC. Sci Adv, 10, 2024
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3JC6
| Structure of the eukaryotic replicative CMG helicase and pumpjack motion | 分子名称: | Cell division control protein 45, DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, ... | 著者 | Li, H, Bai, L, Yuan, Z, Sun, J, Georgescu, R.E, Liu, J, O'Donnell, M.E. | 登録日 | 2015-11-24 | 公開日 | 2016-02-10 | 最終更新日 | 2018-07-18 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation. Nat.Struct.Mol.Biol., 23, 2016
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