7D56
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7D8N
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![BU of 7d8n by Molmil](/molmil-images/mine/7d8n) | Structure of the inactive form of wild-type peptidylarginine deiminase type III (PAD3) crystallized under the condition with high concentrations of Ca2+ | 分子名称: | CALCIUM ION, CHLORIDE ION, GLYCEROL, ... | 著者 | Funabashi, K, Sawata, M, Unno, M. | 登録日 | 2020-10-08 | 公開日 | 2021-06-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.753 Å) | 主引用文献 | Structures of human peptidylarginine deiminase type III provide insights into substrate recognition and inhibitor design. Arch.Biochem.Biophys., 708, 2021
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3A60
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![BU of 3a60 by Molmil](/molmil-images/mine/3a60) | Crystal structure of unphosphorylated p70S6K1 (Form I) | 分子名称: | Ribosomal protein S6 kinase beta-1, STAUROSPORINE | 著者 | Sunami, T, Byrne, N, Diehl, R.E, Funabashi, K, Hall, D.L, Ikuta, M, Patel, S.B, Shipman, J.M, Smith, R.F, Takahashi, I, Zugay-Murphy, J, Iwasawa, Y, Lumb, K.J, Munshi, S.K, Sharma, S. | 登録日 | 2009-08-17 | 公開日 | 2009-10-27 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation. J.Biol.Chem., 285, 2010
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3A62
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![BU of 3a62 by Molmil](/molmil-images/mine/3a62) | Crystal structure of phosphorylated p70S6K1 | 分子名称: | MANGANESE (II) ION, Ribosomal protein S6 kinase beta-1, STAUROSPORINE | 著者 | Sunami, T, Byrne, N, Diehl, R.E, Funabashi, K, Hall, D.L, Ikuta, M, Patel, S.B, Shipman, J.M, Smith, R.F, Takahashi, I, Zugay-Murphy, J, Iwasawa, Y, Lumb, K.J, Munshi, S.K, Sharma, S. | 登録日 | 2009-08-18 | 公開日 | 2009-10-27 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation. J.Biol.Chem., 285, 2010
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3A61
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![BU of 3a61 by Molmil](/molmil-images/mine/3a61) | Crystal structure of unphosphorylated p70S6K1 (Form II) | 分子名称: | Ribosomal protein S6 kinase beta-1, STAUROSPORINE | 著者 | Sunami, T, Byrne, N, Diehl, R.E, Funabashi, K, Hall, D.L, Ikuta, M, Patel, S.B, Shipman, J.M, Smith, R.F, Takahashi, I, Zugay-Murphy, J, Iwasawa, Y, Lumb, K.J, Munshi, S.K, Sharma, S. | 登録日 | 2009-08-18 | 公開日 | 2009-10-27 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.43 Å) | 主引用文献 | Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation. J.Biol.Chem., 285, 2010
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7D5V
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![BU of 7d5v by Molmil](/molmil-images/mine/7d5v) | Structure of the C646A mutant of peptidylarginine deiminase type III (PAD3) | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, Protein-arginine deiminase type-3 | 著者 | Akimoto, M, Mashimo, R, Unno, M. | 登録日 | 2020-09-28 | 公開日 | 2021-06-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.102 Å) | 主引用文献 | Structures of human peptidylarginine deiminase type III provide insights into substrate recognition and inhibitor design. Arch.Biochem.Biophys., 708, 2021
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7DAN
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7D5R
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![BU of 7d5r by Molmil](/molmil-images/mine/7d5r) | Structure of the Ca2+-bound C646A mutant of peptidylarginine deiminase type III (PAD3) | 分子名称: | CALCIUM ION, CHLORIDE ION, GLYCEROL, ... | 著者 | Mashimo, R, Akimoto, M, Unno, M. | 登録日 | 2020-09-28 | 公開日 | 2021-06-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.148 Å) | 主引用文献 | Structures of human peptidylarginine deiminase type III provide insights into substrate recognition and inhibitor design. Arch.Biochem.Biophys., 708, 2021
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7D4Y
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5ZR3
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![BU of 5zr3 by Molmil](/molmil-images/mine/5zr3) | Crystal structure of Hsp90-alpha N-terminal domain in complex with 4-(3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-3-methylbenzamide | 分子名称: | 3-methyl-4-{4-[4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide, Heat shock protein HSP 90-alpha | 著者 | Uno, T, Chong, K.T, Suzuki, T. | 登録日 | 2018-04-23 | 公開日 | 2019-01-02 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Discovery of 3-Ethyl-4-(3-isopropyl-4-(4-(1-methyl-1 H-pyrazol-4-yl)-1 H-imidazol-1-yl)-1 H-pyrazolo[3,4- b]pyridin-1-yl)benzamide (TAS-116) as a Potent, Selective, and Orally Available HSP90 Inhibitor. J. Med. Chem., 62, 2019
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