8U0Q
 
 | | Co-crystal structure of optimized analog TDI-13537 provided new insights into the potency determinants of the sulfonamide inhibitor series | | 分子名称: | Dihydrolipoyl dehydrogenase, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | | 著者 | Dementiev, A.A, Michino, M, Vendome, J, Ginn, J, Bryk, R, Olland, A. | | 登録日 | 2023-08-29 | | 公開日 | 2024-01-03 | | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | | 主引用文献 | Shape-Based Virtual Screening of a Billion-Compound Library Identifies Mycobacterial Lipoamide Dehydrogenase Inhibitors.
Acs Bio Med Chem Au, 3, 2023
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3H5C
 | | X-Ray Structure of Protein Z-Protein Z Inhibitor Complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Protein Z-dependent protease inhibitor, Vitamin K-dependent protein Z, ... | | 著者 | Dementiev, A.A, Huang, X, Olson, S.T, Gettins, P.G.W. | | 登録日 | 2009-04-21 | | 公開日 | 2010-04-28 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3.26 Å) | | 主引用文献 | Basis for the specificity and activation of the serpin protein Z-dependent proteinase inhibitor (ZPI) as an inhibitor of membrane-associated factor Xa.
J.Biol.Chem., 285, 2010
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6B77
 | | Structures of the two-chain human plasma factor XIIa co-crystallized with potent inhibitors | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Coagulation factor XII, GLYCEROL, ... | | 著者 | Dementiev, A.A, Silva, A, Yee, C, Flavin, M.T, Partridge, J.R. | | 登録日 | 2017-10-03 | | 公開日 | 2018-03-21 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.37 Å) | | 主引用文献 | Structures of human plasma beta-factor XIIa cocrystallized with potent inhibitors.
Blood Adv, 2, 2018
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6B74
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1RGH
 | | HYDROLASE, GUANYLORIBONUCLEASE | | 分子名称: | RIBONUCLEASE, SULFATE ION | | 著者 | Sevcik, J, Dauter, Z, Lamzin, V.S, Wilson, K.S. | | 登録日 | 1995-06-05 | | 公開日 | 1996-10-14 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Ribonuclease from Streptomyces aureofaciens at atomic resolution.
Acta Crystallogr.,Sect.D, 52, 1996
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1RGE
 | | HYDROLASE, GUANYLORIBONUCLEASE | | 分子名称: | GUANOSINE-2'-MONOPHOSPHATE, RIBONUCLEASE, SULFATE ION | | 著者 | Sevcik, J, Dauter, Z, Lamzin, V.S, Wilson, K.S. | | 登録日 | 1995-06-05 | | 公開日 | 1996-10-14 | | 最終更新日 | 2017-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | | 主引用文献 | Ribonuclease from Streptomyces aureofaciens at atomic resolution.
Acta Crystallogr.,Sect.D, 52, 1996
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1RGG
 | | HYDROLASE, GUANYLORIBONUCLEASE | | 分子名称: | RIBONUCLEASE, SULFATE ION | | 著者 | Sevcik, J, Dauter, Z, Lamzin, V.S, Wilson, K.S. | | 登録日 | 1995-06-05 | | 公開日 | 1996-10-14 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Ribonuclease from Streptomyces aureofaciens at atomic resolution.
Acta Crystallogr.,Sect.D, 52, 1996
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1RGF
 | | HYDROLASE, GUANYLORIBONUCLEASE | | 分子名称: | RIBONUCLEASE, SULFATE ION | | 著者 | Sevcik, J, Dauter, Z, Lamzin, V.S, Wilson, K.S. | | 登録日 | 1995-06-05 | | 公開日 | 1996-10-14 | | 最終更新日 | 2017-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Ribonuclease from Streptomyces aureofaciens at atomic resolution.
Acta Crystallogr.,Sect.D, 52, 1996
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1RSN
 | | RIBONUCLEASE (RNASE SA) (E.C.3.1.4.8) COMPLEXED WITH EXO-2',3'-CYCLOPHOSPHOROTHIOATE | | 分子名称: | GUANOSINE-2',3'-CYCLOPHOSPHOROTHIOATE, RIBONUCLEASE SA, SULFATE ION | | 著者 | Sevcik, J, Dauter, Z, Lamzin, V.S, Wilson, K.S. | | 登録日 | 1995-09-01 | | 公開日 | 1995-12-07 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Complex of ribonuclease Sa with a cyclic nucleotide and a proposed model for the reaction intermediate.
Eur.J.Biochem., 216, 1993
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8DKN
 | | PPARg bound to T0070907 and Co-R peptide | | 分子名称: | 2-chloro-5-nitro-N-(pyridin-4-yl)benzamide, 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Nuclear receptor corepressor 1 peptide, ... | | 著者 | Larsen, N.A, Tsai, J. | | 登録日 | 2022-07-05 | | 公開日 | 2022-09-07 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPAR gamma by inverse agonists.
J.Biol.Chem., 298, 2022
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8DKV
 | | PPARg bound to JTP-426467 and Co-R peptide | | 分子名称: | 2-chloro-N-[4-(5-methyl-1,3-benzoxazol-2-yl)phenyl]-5-nitrobenzamide, 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Nuclear receptor corepressor 1, ... | | 著者 | Larsen, N.A. | | 登録日 | 2022-07-06 | | 公開日 | 2022-09-07 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | | 主引用文献 | Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPAR gamma by inverse agonists.
J.Biol.Chem., 298, 2022
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8DSZ
 | | PPARg bound to partial agonist H3B-487 | | 分子名称: | (2R)-2-{5-[(5-{[(1R)-1-(4-tert-butylphenyl)ethyl]carbamoyl}-2,3-dimethyl-1H-indol-1-yl)methyl]-2-chlorophenoxy}propanoic acid, Peroxisome proliferator-activated receptor gamma | | 著者 | Larsen, N.A. | | 登録日 | 2022-07-24 | | 公開日 | 2022-09-07 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPAR gamma by inverse agonists.
J.Biol.Chem., 298, 2022
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8DSY
 | | PPARg bound to inverse agonist H3B-343 | | 分子名称: | Peroxisome proliferator-activated receptor gamma, {5-[(5-{[(4-tert-butylphenyl)methyl]carbamoyl}-2,3-dimethyl-1H-indol-1-yl)methyl]-2-chlorophenoxy}acetic acid | | 著者 | Larsen, N.A. | | 登録日 | 2022-07-24 | | 公開日 | 2022-09-07 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPAR gamma by inverse agonists.
J.Biol.Chem., 298, 2022
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