8DSZ

PPARg bound to partial agonist H3B-487

Summary for 8DSZ

Entry DOI	10.2210/pdb8dsz/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, (2R)-2-{5-[(5-{[(1R)-1-(4-tert-butylphenyl)ethyl]carbamoyl}-2,3-dimethyl-1H-indol-1-yl)methyl]-2-chlorophenoxy}propanoic acid (3 entities in total)
Functional Keywords	pparg, partial agonist, h3b-487, nuclear protein
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	63424.59
Authors	Larsen, N.A. (deposition date: 2022-07-24, release date: 2022-09-07, Last modification date: 2023-10-25)
Primary citation	Irwin, S.,Karr, C.,Furman, C.,Tsai, J.,Gee, P.,Banka, D.,Wibowo, A.S.,Dementiev, A.A.,O'Shea, M.,Yang, J.,Lowe, J.,Mitchell, L.,Ruppel, S.,Fekkes, P.,Zhu, P.,Korpal, M.,Larsen, N.A. Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPAR gamma by inverse agonists. J.Biol.Chem., 298:102539-102539, 2022 Cited by PubMed: 36179791 DOI: 10.1016/j.jbc.2022.102539 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation