8DKV

PPARg bound to JTP-426467 and Co-R peptide

Summary for 8DKV

• Entry DOI: 10.2210/pdb8dkv/pdb
• Descriptor: Peroxisome proliferator-activated receptor gamma, Nuclear receptor corepressor 1, 2-chloro-N-[4-(5-methyl-1,3-benzoxazol-2-yl)phenyl]-5-nitrobenzamide, ... (6 entities in total)
• Functional Keywords: pparg, inverse agonist, covalent, jtp-426467, nuclear protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 33672.57

Authors

Larsen, N.A. (deposition date: 2022-07-06, release date: 2022-09-07, Last modification date: 2023-10-25)

• Primary citation: Irwin, S.,Karr, C.,Furman, C.,Tsai, J.,Gee, P.,Banka, D.,Wibowo, A.S.,Dementiev, A.A.,O'Shea, M.,Yang, J.,Lowe, J.,Mitchell, L.,Ruppel, S.,Fekkes, P.,Zhu, P.,Korpal, M.,Larsen, N.A.; Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPAR gamma by inverse agonists.; J.Biol.Chem., 298:102539-102539, 2022; PubMed: 36179791; DOI: 10.1016/j.jbc.2022.102539

Experimental method

X-RAY DIFFRACTION (1.59 Å)