3LPU
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![BU of 3lpu by Molmil](/molmil-images/mine/3lpu) | HIV integrase | 分子名称: | (2S)-2-(6-chloro-2-methyl-4-phenylquinolin-3-yl)pentanoic acid, 2-[3-[3-(2-hydroxyethoxy)propoxy]propoxy]ethanol, CALCIUM ION, ... | 著者 | Nicolet, S, Christ, F, Voet, A, Marchand, A, Strelkov, S.V, de Maeyer, M, Chaltin, P, Debyzer, Z. | 登録日 | 2010-02-06 | 公開日 | 2010-05-12 | 最終更新日 | 2021-11-10 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication. Nat.Chem.Biol., 6, 2010
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3LPT
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![BU of 3lpt by Molmil](/molmil-images/mine/3lpt) | HIV integrase | 分子名称: | (6-chloro-2-oxo-4-phenyl-1,2-dihydroquinolin-3-yl)acetic acid, 2-[3-[3-(2-hydroxyethoxy)propoxy]propoxy]ethanol, CALCIUM ION, ... | 著者 | Nicolet, S, Christ, F, Voet, A, Marchand, A, Strelkov, S.V, de Maeyer, M, Chaltin, P, Debyzer, Z. | 登録日 | 2010-02-05 | 公開日 | 2010-05-12 | 最終更新日 | 2021-11-10 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication. Nat.Chem.Biol., 6, 2010
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7ALX
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![BU of 7alx by Molmil](/molmil-images/mine/7alx) | Sav-SOD: Chimeric Streptavidin-cSOD as Host for Artificial Metalloenzymes | 分子名称: | ((4S)-1,3-dimesityl-4-((5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)methyl)imidazolidin-2-yl)gold, Streptavidin,Superoxide dismutase [Cu-Zn],Streptavidin | 著者 | Igareta, N.V, Christoffel, F, Peterson, R.L, Ward, T.R. | 登録日 | 2020-10-07 | 公開日 | 2021-07-14 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Design and evolution of chimeric streptavidin for protein-enabled dual gold catalysis Nat Catal, 4, 2021
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4IKF
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![BU of 4ikf by Molmil](/molmil-images/mine/4ikf) | PFV intasome with inhibitor MB-76 | 分子名称: | 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3', 5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3', AMMONIUM ION, ... | 著者 | Taltynov, O, Demeulemeester, J, Desimmie, B.A, Suchaud, V, Billamboz, M, Lion, C, Bailly, F, Debyser, Z, Cotelle, P, Christ, F, Strelkov, S.V. | 登録日 | 2012-12-26 | 公開日 | 2013-04-03 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | 2-Hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs), novel inhibitors of HIV integrase with a high barrier to resistance. Acs Chem.Biol., 8, 2013
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2N3A
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![BU of 2n3a by Molmil](/molmil-images/mine/2n3a) | Solution structure of LEDGF/p75 IBD in complex with POGZ peptide (1389-1404) | 分子名称: | PC4 and SFRS1-interacting protein, Pogo transposable element with ZNF domain | 著者 | Tesina, P, Cermakova, K, Horejsi, M, Prochazkova, K, Fabry, M, Sharma, S, Christ, F, Demeulemeester, J, Debyser, Z, De Rijck, J, Veverka, V, Rezacova, P. | 登録日 | 2015-05-26 | 公開日 | 2015-08-19 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif. Nat Commun, 6, 2015
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3EY4
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![BU of 3ey4 by Molmil](/molmil-images/mine/3ey4) | Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11-hydroxysteroid dehydrogenase type 1 (11-HSD1) inhibitors: Reducing pregnane X receptor (PXR) activity and exploring activity in a monkey pharmacodynamic model | 分子名称: | (5S)-2-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-5-(1-hydroxy-1-methylethyl)-5-methyl-1,3-thiazol-4(5H)-one, 11-beta-Hydroxysteroid Dehydrogenase 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Zhang, J.D, Jordan, S.R, Li, V. | 登録日 | 2008-10-17 | 公開日 | 2008-11-11 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11-hydroxysteroid dehydrogenase type 1 (11-HSD1) inhibitors: Reducing pregnane X receptor (PXR) activity and exploring activity in a monkey pharmacodynamic model To be Published, 2008
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6T3I
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![BU of 6t3i by Molmil](/molmil-images/mine/6t3i) | Solution structure of the HRP2 IBD | 分子名称: | Hepatoma-derived growth factor-related protein 2 | 著者 | Veverka, V. | 登録日 | 2019-10-11 | 公開日 | 2020-11-18 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | Unlike Its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival. Cells, 10, 2021
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5YI9
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![BU of 5yi9 by Molmil](/molmil-images/mine/5yi9) | |
6TRJ
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![BU of 6trj by Molmil](/molmil-images/mine/6trj) | LEDGF/p75 IBD dimer | 分子名称: | PC4 and SFRS1-interacting protein | 著者 | Kugler, M, Brynda, J. | 登録日 | 2019-12-19 | 公開日 | 2020-09-09 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Fine-tuning of the LEDGF/p75 interaction network by dimerization Structure
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6TVM
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![BU of 6tvm by Molmil](/molmil-images/mine/6tvm) | |
6EMR
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![BU of 6emr by Molmil](/molmil-images/mine/6emr) | |
6EMP
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![BU of 6emp by Molmil](/molmil-images/mine/6emp) | |
6EMO
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![BU of 6emo by Molmil](/molmil-images/mine/6emo) | |
6EMQ
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![BU of 6emq by Molmil](/molmil-images/mine/6emq) | |
4OL0
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![BU of 4ol0 by Molmil](/molmil-images/mine/4ol0) | Crystal structure of transportin-SR2, a karyopherin involved in human disease, in complex with Ran | 分子名称: | GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Tsirkone, V.G, Strelkov, S.V. | 登録日 | 2014-01-23 | 公開日 | 2014-04-09 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structure of transportin SR2, a karyopherin involved in human disease, in complex with Ran. Acta Crystallogr.,Sect.F, 70, 2014
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6I6F
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![BU of 6i6f by Molmil](/molmil-images/mine/6i6f) | SEPIAPTERIN REDUCTASE IN COMPLEX WITH COMPOUND 1 | 分子名称: | 1,2-ETHANEDIOL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Sepiapterin reductase, ... | 著者 | Alen, J, Schade, M, Wagener, M, Blaesse, M. | 登録日 | 2018-11-15 | 公開日 | 2019-07-10 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Fragment-Based Discovery of Novel Potent Sepiapterin Reductase Inhibitors. J.Med.Chem., 62, 2019
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6I6V
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![BU of 6i6v by Molmil](/molmil-images/mine/6i6v) | SEPIAPTERIN REDUCTASE IN COMPLEX WITH COMPOUND 6 | 分子名称: | 1,2-ETHANEDIOL, 2-[[(3~{R})-oxan-3-yl]methylsulfonyl]-2-azaspiro[4.5]decane, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Alen, J, Schade, M, Wagener, M, Blaesse, M. | 登録日 | 2018-11-15 | 公開日 | 2019-07-10 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | 主引用文献 | Fragment-Based Discovery of Novel Potent Sepiapterin Reductase Inhibitors. J.Med.Chem., 62, 2019
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6I6P
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![BU of 6i6p by Molmil](/molmil-images/mine/6i6p) | SEPIAPTERIN REDUCTASE IN COMPLEX WITH COMPOUND 3 | 分子名称: | 1,2-ETHANEDIOL, 6-azaspiro[3.4]octan-6-yl-[2,4-bis(chloranyl)-6-oxidanyl-phenyl]methanone, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Alen, J, Schade, M, Wagener, M, Blaesse, M. | 登録日 | 2018-11-15 | 公開日 | 2019-07-10 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Fragment-Based Discovery of Novel Potent Sepiapterin Reductase Inhibitors. J.Med.Chem., 62, 2019
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6I6C
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![BU of 6i6c by Molmil](/molmil-images/mine/6i6c) | SEPIAPTERIN REDUCTASE IN COMPLEX WITH COMPOUND 2 | 分子名称: | (1~{R},2~{S},4~{S})-~{N}-(3-chloranyl-4-cyano-phenyl)sulfonylbicyclo[2.2.1]heptane-2-carboxamide, 1,2-ETHANEDIOL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Alen, J, Schade, M, Wagener, M, Blaesse, M. | 登録日 | 2018-11-15 | 公開日 | 2019-07-10 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Fragment-Based Discovery of Novel Potent Sepiapterin Reductase Inhibitors. J.Med.Chem., 62, 2019
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6I6T
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![BU of 6i6t by Molmil](/molmil-images/mine/6i6t) | SEPIAPTERIN REDUCTASE IN COMPLEX WITH COMPOUND 5 | 分子名称: | 1,2-ETHANEDIOL, 4-bromanyl-1-oxidanyl-naphthalene-2-carboxylic acid, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Alen, J, Schade, M, Wagener, M, Blaesse, M. | 登録日 | 2018-11-15 | 公開日 | 2019-07-10 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Fragment-Based Discovery of Novel Potent Sepiapterin Reductase Inhibitors. J.Med.Chem., 62, 2019
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6I79
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![BU of 6i79 by Molmil](/molmil-images/mine/6i79) | SEPIAPTERIN REDUCTASE IN COMPLEX WITH COMPOUND 4 | 分子名称: | 6-[(4-~{tert}-butyl-1,3-thiazol-2-yl)methyl]-4,6-diazaspiro[2.4]heptane-5,7-dione, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Sepiapterin reductase | 著者 | Alen, J, Schade, M, Wagener, M, Blaesse, M. | 登録日 | 2018-11-16 | 公開日 | 2019-07-10 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Fragment-Based Discovery of Novel Potent Sepiapterin Reductase Inhibitors. J.Med.Chem., 62, 2019
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