3LPU

HIV integrase

Summary for 3LPU

• Entry DOI: 10.2210/pdb3lpu/pdb
• Related: 1HYV 3LPT
• Descriptor: Integrase, (2S)-2-(6-chloro-2-methyl-4-phenylquinolin-3-yl)pentanoic acid, 2-[3-[3-(2-hydroxyethoxy)propoxy]propoxy]ethanol, ... (7 entities in total)
• Functional Keywords: hiv, integrase, ledgf/p75 small molecule, inhibitor, endonuclease, hydrolase, nuclease, transferase, viral protein
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 1
• Total formula weight: 19551.35

Authors

Nicolet, S.,Christ, F.,Voet, A.,Marchand, A.,Strelkov, S.V.,de Maeyer, M.,Chaltin, P.,Debyzer, Z. (deposition date: 2010-02-06, release date: 2010-05-12, Last modification date: 2021-11-10)

• Primary citation: Christ, F.,Voet, A.,Marchand, A.,Nicolet, S.,Desimmie, B.A.,Marchand, D.,Bardiot, D.,Van der Veken, N.J.,Van Remoortel, B.,Strelkov, S.V.,De Maeyer, M.,Chaltin, P.,Debyser, Z.; Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication.; Nat.Chem.Biol., 6:442-448, 2010; PubMed: 20473303; DOI: 10.1038/nchembio.370

Experimental method

X-RAY DIFFRACTION (1.95 Å)