6I79

SEPIAPTERIN REDUCTASE IN COMPLEX WITH COMPOUND 4

Summary for 6I79

Entry DOI	10.2210/pdb6i79/pdb
Descriptor	Sepiapterin reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-[(4-~{tert}-butyl-1,3-thiazol-2-yl)methyl]-4,6-diazaspiro[2.4]heptane-5,7-dione, ... (4 entities in total)
Functional Keywords	sepiapterin-reductase, oxidoreductase, proteros biostructures gmbh
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	61942.46
Authors	Alen, J.,Schade, M.,Wagener, M.,Blaesse, M. (deposition date: 2018-11-16, release date: 2019-07-10, Last modification date: 2019-07-24)
Primary citation	Alen, J.,Schade, M.,Wagener, M.,Christian, F.,Nordhoff, S.,Merla, B.,Dunkern, T.R.,Bahrenberg, G.,Ratcliffe, P. Fragment-Based Discovery of Novel Potent Sepiapterin Reductase Inhibitors. J.Med.Chem., 62:6391-6397, 2019 Cited by PubMed: 31244106 DOI: 10.1021/acs.jmedchem.9b00218 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.63 Å)

Structure validation