4IKF
PFV intasome with inhibitor MB-76
Summary for 4IKF
Entry DOI | 10.2210/pdb4ikf/pdb |
Descriptor | Integrase, N-(4-fluorobenzyl)-2,3-dihydroxy-1-oxo-1,2-dihydroisoquinoline-4-carboxamide, 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3', ... (10 entities in total) |
Functional Keywords | integrase zinc binding, core and dna-binding domains, dna integration, inhibitor, nucleus, viral protein-dna-inhibitor complex, endonuclease, nucleotidyltransferase, recombination, hhcc motif, dde motif, viral protein/dna/inhibitor |
Biological source | Human spumaretrovirus (SFVcpz(hu)) |
Total number of polymer chains | 4 |
Total formula weight | 101082.61 |
Authors | Taltynov, O.,Demeulemeester, J.,Desimmie, B.A.,Suchaud, V.,Billamboz, M.,Lion, C.,Bailly, F.,Debyser, Z.,Cotelle, P.,Christ, F.,Strelkov, S.V. (deposition date: 2012-12-26, release date: 2013-04-03, Last modification date: 2024-02-28) |
Primary citation | Desimmie, B.A.,Demeulemeester, J.,Suchaud, V.,Taltynov, O.,Billamboz, M.,Lion, C.,Bailly, F.,Strelkov, S.V.,Debyser, Z.,Cotelle, P.,Christ, F. 2-Hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs), novel inhibitors of HIV integrase with a high barrier to resistance. Acs Chem.Biol., 8:1187-1194, 2013 Cited by PubMed: 23517458DOI: 10.1021/cb4000426 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.4 Å) |
Structure validation
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