3OR6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3or6 by Molmil](/molmil-images/mine/3or6) | On the structural basis of modal gating behavior in K+channels - E71Q | 分子名称: | POTASSIUM ION, Voltage-gated potassium channel, antibody fab fragment heavy chain, ... | 著者 | Chakrapani, S, Cordero-Morales, J.F, Jogini, V, Perozo, E. | 登録日 | 2010-09-06 | 公開日 | 2011-01-05 | 最終更新日 | 2018-08-29 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | On the structural basis of modal gating behavior in K(+) channels. Nat.Struct.Mol.Biol., 18, 2011
|
|
3OR7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3or7 by Molmil](/molmil-images/mine/3or7) | On the structural basis of modal gating behavior in K+channels - E71I | 分子名称: | POTASSIUM ION, Voltage-gated potassium channel, antibody fab fragment heavy chain, ... | 著者 | Chakrapani, S, Cordero-Morales, J.F, Jogini, V, Pan, A.C, Cortes, D.M, Roux, B, Perozo, E. | 登録日 | 2010-09-06 | 公開日 | 2011-01-05 | 最終更新日 | 2018-08-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | On the structural basis of modal gating behavior in K(+) channels. Nat.Struct.Mol.Biol., 18, 2011
|
|
4YEU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4yeu by Molmil](/molmil-images/mine/4yeu) | |
6W1J
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6w1j by Molmil](/molmil-images/mine/6w1j) | Cryo-EM structure of 5HT3A receptor in presence of Alosetron | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(4-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, ... | 著者 | Basak, S, Chakrapani, S. | 登録日 | 2020-03-04 | 公開日 | 2021-01-13 | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | 主引用文献 | High-resolution structures of multiple 5-HT 3A R-setron complexes reveal a novel mechanism of competitive inhibition. Elife, 9, 2020
|
|
6VM3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6vm3 by Molmil](/molmil-images/mine/6vm3) | Full length Glycine receptor reconstituted in lipid nanodisc in Gly/IVM-conformation (State-3) | 分子名称: | (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCINE, ... | 著者 | Kumar, A, Basak, S, Chakrapani, S. | 登録日 | 2020-01-27 | 公開日 | 2020-07-29 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | 主引用文献 | Mechanisms of activation and desensitization of full-length glycine receptor in lipid nanodiscs. Nat Commun, 11, 2020
|
|
6NP0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6np0 by Molmil](/molmil-images/mine/6np0) | Cryo-EM structure of 5HT3A receptor in presence of granisetron | 分子名称: | 1-methyl-N-[(1R,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Basak, S, Chakrapani, S. | 登録日 | 2019-01-17 | 公開日 | 2019-07-24 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | 主引用文献 | Molecular mechanism of setron-mediated inhibition of full-length 5-HT3Areceptor. Nat Commun, 10, 2019
|
|
5J0Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5j0z by Molmil](/molmil-images/mine/5j0z) | Crystal structure of GLIC in complex with DHA | 分子名称: | ACETATE ION, CHLORIDE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, ... | 著者 | Basak, S, Schmandt, N, Chakrapani, S. | 登録日 | 2016-03-28 | 公開日 | 2017-03-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Crystal structure and dynamics of a lipid-induced potential desensitized-state of a pentameric ligand-gated channel. Elife, 6, 2017
|
|
7M6M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7m6m by Molmil](/molmil-images/mine/7m6m) | Full length alpha1 Glycine receptor in presence of 32uM Tetrahydrocannabinol | 分子名称: | (6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycine receptor subunit alphaZ1 | 著者 | Kumar, A, Chakrapani, S. | 登録日 | 2021-03-26 | 公開日 | 2022-08-03 | 最終更新日 | 2022-09-07 | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | 主引用文献 | Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs. Nat Commun, 13, 2022
|
|
7M6N
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7m6n by Molmil](/molmil-images/mine/7m6n) | |
7M6Q
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7m6q by Molmil](/molmil-images/mine/7m6q) | Full length alpha1 Glycine receptor in presence of 1mM Glycine and 32uM Tetrahydrocannabinol State 1 | 分子名称: | (6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCINE, ... | 著者 | Kumar, A, Chakrapani, S. | 登録日 | 2021-03-26 | 公開日 | 2022-08-03 | 最終更新日 | 2022-09-07 | 実験手法 | ELECTRON MICROSCOPY (2.91 Å) | 主引用文献 | Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs. Nat Commun, 13, 2022
|
|
7M6R
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7m6r by Molmil](/molmil-images/mine/7m6r) | |
7M6S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7m6s by Molmil](/molmil-images/mine/7m6s) | |
7M6O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7m6o by Molmil](/molmil-images/mine/7m6o) | Full length alpha1 Glycine receptor in presence of 0.1mM Glycine and 32uM Tetrahydrocannabinol | 分子名称: | (6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCINE, ... | 著者 | Kumar, A, Chakrapani, S. | 登録日 | 2021-03-26 | 公開日 | 2022-08-03 | 最終更新日 | 2022-09-07 | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | 主引用文献 | Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs. Nat Commun, 13, 2022
|
|
7M6P
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7m6p by Molmil](/molmil-images/mine/7m6p) | |
6DG8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6dg8 by Molmil](/molmil-images/mine/6dg8) | |
6DG7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6dg7 by Molmil](/molmil-images/mine/6dg7) | |
6B5V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6b5v by Molmil](/molmil-images/mine/6b5v) | Structure of TRPV5 in complex with econazole | 分子名称: | 1-[(2R)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, CALCIUM ION, Transient receptor potential cation channel subfamily V member 5 | 著者 | Hughes, T.E.T, Lodowski, D.T, Huynh, K.W, Yazici, A, del Rosario, J, Kapoor, A, Basak, S, Samanta, A, Chakrapani, S, Zhou, Z.H, Filizola, M, Rohacs, T, Han, S, Moiseenkova-Bell, V.Y. | 登録日 | 2017-09-29 | 公開日 | 2017-12-27 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM. Nat. Struct. Mol. Biol., 25, 2018
|
|
7TVI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7tvi by Molmil](/molmil-images/mine/7tvi) | Alpha1/BetaB Heteromeric Glycine Receptor in Glycine-Bound State | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCINE, Glycine receptor beta subunit 2, ... | 著者 | Gibbs, E, Chakrapani, S, Kumar, A. | 登録日 | 2022-02-04 | 公開日 | 2023-03-22 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Conformational transitions and allosteric modulation in a heteromeric glycine receptor Nat Commun, 14, 2023
|
|
7TU9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7tu9 by Molmil](/molmil-images/mine/7tu9) | Alpha1/BetaB Heteromeric Glycine Receptor in Strychnine-Bound State | 分子名称: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycine receptor beta subunit 2, ... | 著者 | Gibbs, E, Kumar, A, Chakrapani, S. | 登録日 | 2022-02-02 | 公開日 | 2023-03-22 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Conformational transitions and allosteric modulation in a heteromeric glycine receptor Nat Commun, 14, 2023
|
|
6BE1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6be1 by Molmil](/molmil-images/mine/6be1) | Cryo-EM structure of serotonin receptor | 分子名称: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Basak, S, Chakrapani, S. | 登録日 | 2017-10-24 | 公開日 | 2018-02-07 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (4.31 Å) | 主引用文献 | Cryo-EM structure of 5-HT Nat Commun, 9, 2018
|
|
6W1M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6w1m by Molmil](/molmil-images/mine/6w1m) | Cryo-EM structure of 5HT3A receptor in presence of Ondansetron | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(4-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, ... | 著者 | Basak, S, Chakrapani, S. | 登録日 | 2020-03-04 | 公開日 | 2021-01-13 | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | 主引用文献 | High-resolution structures of multiple 5-HT 3A R-setron complexes reveal a novel mechanism of competitive inhibition. Elife, 9, 2020
|
|
6W1Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6w1y by Molmil](/molmil-images/mine/6w1y) | Cryo-EM structure of 5HT3A receptor in presence of Palonosetron | 分子名称: | (3~{a}~{S})-2-[(3~{S})-1-azabicyclo[2.2.2]octan-3-yl]-3~{a},4,5,6-tetrahydro-3~{H}-benzo[de]isoquinolin-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(4-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Basak, S, Chakrapani, S. | 登録日 | 2020-03-04 | 公開日 | 2021-01-13 | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | 主引用文献 | High-resolution structures of multiple 5-HT 3A R-setron complexes reveal a novel mechanism of competitive inhibition. Elife, 9, 2020
|
|
8FE1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8fe1 by Molmil](/molmil-images/mine/8fe1) | Alpha1/BetaB Heteromeric Glycine Receptor in 1 mM Glycine 20 uM Ivermectin State | 分子名称: | (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Gibbs, E, Chakrapani, S. | 登録日 | 2022-12-05 | 公開日 | 2023-03-22 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Conformational transitions and allosteric modulation in a heteromeric glycine receptor. Nat Commun, 14, 2023
|
|
3FB7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3fb7 by Molmil](/molmil-images/mine/3fb7) | Open KcsA potassium channel in the presence of Rb+ ion | 分子名称: | RUBIDIUM ION, Voltage-gated potassium channel, antibody fab fragment heavy chain, ... | 著者 | Cuello, L.G, Jogini, V, Cortes, D.M, Pan, A.C, Gagnon, D.H, Cordero-Morales, J.F, Chakrapani, S, Roux, B, Perozo, E. | 登録日 | 2008-11-18 | 公開日 | 2010-07-14 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Open KcsA potassium channel in the presence of Rb+ ion TO BE PUBLISHED
|
|
8FSZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8fsz by Molmil](/molmil-images/mine/8fsz) | Full-length mouse 5-HT3A receptor in complex with ALB148471, open-like | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-[(1R,3S,5R)-1-azabicyclo[3.2.2]nonan-3-yl]-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indazol-6-one, 5-hydroxytryptamine receptor 3A | 著者 | Felt, K.C, Chakrapani, S. | 登録日 | 2023-01-11 | 公開日 | 2023-12-27 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.79 Å) | 主引用文献 | Structural basis for partial agonism in 5-HT 3A receptors. Nat.Struct.Mol.Biol., 31, 2024
|
|