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9BWT
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BU of 9bwt by Molmil
human sodium chloride cotransporter NCC S344E in the phosphorylation state and in complex with hydrochlorothiazide
分子名称: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, ADENOSINE-5'-TRIPHOSPHATE, Solute carrier family 12 member 3
著者Cao, E.H, Zhao, Y.X.
登録日2024-05-21
公開日2024-09-04
実験手法ELECTRON MICROSCOPY (2.5 Å)
主引用文献Structural bases for Na + -Cl - cotransporter inhibition by thiazide diuretic drugs and activation by kinases.
Nat Commun, 15, 2024
7TTI
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BU of 7tti by Molmil
Human KCC1 bound with VU0463271 In an outward-open state
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-cyclopropyl-N-(4-methyl-1,3-thiazol-2-yl)-2-[(6-phenylpyridazin-3-yl)sulfanyl]acetamide, Solute carrier family 12 member 4
著者Zhao, Y.X, Cao, E.H.
登録日2022-02-01
公開日2022-06-29
最終更新日2022-07-13
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structure of the human cation-chloride cotransport KCC1 in an outward-open state.
Proc.Natl.Acad.Sci.USA, 119, 2022
7TTH
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BU of 7tth by Molmil
Human potassium-chloride cotransporter 1 in inward-open state
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, POTASSIUM ION, Solute carrier family 12 member 4
著者Zhao, Y.X, Cao, E.H.
登録日2022-02-01
公開日2022-06-29
最終更新日2022-07-13
実験手法ELECTRON MICROSCOPY (3.25 Å)
主引用文献Structure of the human cation-chloride cotransport KCC1 in an outward-open state.
Proc.Natl.Acad.Sci.USA, 119, 2022
7S1X
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BU of 7s1x by Molmil
Cryo-EM structure of human NKCC1 K289NA492EL671C bound with bumetanide
分子名称: 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid, CHLORIDE ION, POTASSIUM ION, ...
著者Zhao, Y.X, Cao, E.H.
登録日2021-09-02
公開日2022-05-25
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide
Nat Commun, 13, 2022
7S1Z
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BU of 7s1z by Molmil
Cryo-EM structure of Human NKCC1 K289NA492EL671C
分子名称: Solute carrier family 12 member 2
著者Zhao, Y.X, Cao, E.H.
登録日2021-09-02
公開日2022-05-25
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide
Nat Commun, 13, 2022
7S1Y
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BU of 7s1y by Molmil
Cryo-EM structure of human NKCC1 K289NA492E bound with bumetanide
分子名称: 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid, CHLORIDE ION, POTASSIUM ION, ...
著者Zhao, Y.X, Cao, E.h.
登録日2021-09-02
公開日2022-05-25
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide
Nat Commun, 13, 2022
8VPN
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BU of 8vpn by Molmil
Phosphorylated human NCC in complex with indapamide
分子名称: 4-chloro-N-[(2S)-2-methyl-2,3-dihydro-1H-indol-1-yl]-3-sulfamoylbenzamide, ADENOSINE-5'-TRIPHOSPHATE, Solute carrier family 12 member 3
著者Zhao, Y.X, Cao, E.H.
登録日2024-01-16
公開日2024-09-04
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Structural bases for Na + -Cl - cotransporter inhibition by thiazide diuretic drugs and activation by kinases.
Nat Commun, 15, 2024
8VPP
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BU of 8vpp by Molmil
Phosphorylated human NCC in complex with chlorthalidone
分子名称: 2-chloro-5-[(1S)-1-hydroxy-3-oxo-2H-isoindol-1-yl]benzenesulfonamide, Solute carrier family 12 member 3
著者Zhao, Y.X, Cao, E.H.
登録日2024-01-16
公開日2024-09-04
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural bases for Na + -Cl - cotransporter inhibition by thiazide diuretic drugs and activation by kinases.
Nat Commun, 15, 2024

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件を2024-10-02に公開中

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