7MLK
 
 | | Crystal structure of human PI3Ka (p110a subunit) with MMV085400 bound to the active site determined at 2.9 angstroms resolution | | 分子名称: | 4-[6-(3,4,5-trimethoxyanilino)pyrazin-2-yl]benzamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | | 著者 | Krake, S.H, Martinez, P.D.G, Poggi, M.L, Ferreira, M.S, Aguiar, A.C.C, Souza, G.E, Wenlock, M, Jones, B, Steinbrecher, T, Day, T, McPhail, J, Burke, J, Yeo, T, Mok, S, Uhlemann, A.C, Fidock, D.A, Chen, P, Grodsky, N, Deng, Y.L, Guido, R.V.C, Campbell, S.F, Willis, P.A, Dias, L.C. | | 登録日 | 2021-04-28 | | 公開日 | 2022-05-04 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.91 Å) | | 主引用文献 | Discovery of 2,6-disubstituted pyrazines as potent PI4K inhibitors with antimalarial activity
To Be Published
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1JQ5
 | | Bacillus Stearothermophilus Glycerol dehydrogenase complex with NAD+ | | 分子名称: | Glycerol dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ZINC ION | | 著者 | Ruzheinikov, S.N, Burke, J, Sedelnikova, S, Baker, P.J, Taylor, R, Bullough, P.A, Muir, N.M, Gore, M.G, Rice, D.W. | | 登録日 | 2001-08-03 | | 公開日 | 2001-10-01 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Glycerol dehydrogenase. structure, specificity, and mechanism of a family III polyol dehydrogenase.
Structure, 9, 2001
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1JPU
 | | Crystal Structure of Bacillus Stearothermophilus Glycerol Dehydrogenase | | 分子名称: | ZINC ION, glycerol dehydrogenase | | 著者 | Ruzheinikov, S.N, Burke, J, Sedelnikova, S, Baker, P.J, Taylor, R, Bullough, P.A, Muir, N.M, Gore, M.G, Rice, D.W. | | 登録日 | 2001-08-03 | | 公開日 | 2001-10-03 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Glycerol dehydrogenase. structure, specificity, and mechanism of a family III polyol dehydrogenase.
Structure, 9, 2001
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1JQA
 | | Bacillus stearothermophilus glycerol dehydrogenase complex with glycerol | | 分子名称: | GLYCEROL, Glycerol Dehydrogenase, ZINC ION | | 著者 | Ruzheinikov, S.N, Burke, J, Sedelnikova, S, Baker, P.J, Taylor, R, Bullough, P.A, Muir, N.M, Gore, M.G, Rice, D.W. | | 登録日 | 2001-08-04 | | 公開日 | 2001-10-03 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Glycerol dehydrogenase. structure, specificity, and mechanism of a family III polyol dehydrogenase.
Structure, 9, 2001
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1GJW
 | | Thermotoga maritima maltosyltransferase complex with maltose | | 分子名称: | MALTODEXTRIN GLYCOSYLTRANSFERASE, PHOSPHATE ION, alpha-D-glucopyranose, ... | | 著者 | Roujeinikova, A, Raasch, C, Burke, J, Baker, P.J, Liebl, W, Rice, D.W. | | 登録日 | 2001-08-03 | | 公開日 | 2001-09-06 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | The Crystal Structure of Thermotoga Maritima Maltosyltransferase and its Implications for the Molecular Basis of the Novel Transfer Specificity
J.Mol.Biol., 312, 2001
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1GJU
 | | Maltosyltransferase from Thermotoga maritima | | 分子名称: | MALTODEXTRIN GLYCOSYLTRANSFERASE, PHOSPHATE ION | | 著者 | Roujeinikova, A, Raasch, C, Burke, J, Baker, P.J, Liebl, W, Rice, D.W. | | 登録日 | 2001-08-02 | | 公開日 | 2001-09-06 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | The Crystal Structure of Thermotoga Maritima Maltosyltransferase and its Implications for the Molecular Basis of the Novel Transfer Specificity
J.Mol.Biol., 312, 2001
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3L0H
 | | Crystal Structure Analysis of W21A mutant of human GSTA1-1 in complex with S-hexylglutathione | | 分子名称: | Glutathione S-transferase A1, S-HEXYLGLUTATHIONE | | 著者 | Fanucchi, S, Achilonu, I.A, Adamson, R.J, Fernandes, M.A, Burke, J.P, Dirr, H.W. | | 登録日 | 2009-12-10 | | 公開日 | 2010-01-12 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | | 主引用文献 | Stability of the domain interface contributes towards the catalytic function at the H-site of class alpha glutathione transferase A1-1.
Biochim.Biophys.Acta, 1804, 2010
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3KTL
 | | Crystal Structure of an I71A human GSTA1-1 mutant in complex with S-hexylglutathione | | 分子名称: | Glutathione S-transferase A1, S-HEXYLGLUTATHIONE | | 著者 | Achilonu, I.A, Gildenhuys, S, Fernandes, M.A, Fanucchi, S, Dirr, H.W. | | 登録日 | 2009-11-25 | | 公開日 | 2009-12-22 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | The role of a topologically conserved isoleucine in glutathione transferase structure, stability and function.
Acta Crystallogr.,Sect.F, 66, 2010
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2R3X
 | | Crystal structure of an R15L hGSTA1-1 mutant complexed with S-hexyl-glutathione | | 分子名称: | Glutathione S-transferase A1, S-HEXYLGLUTATHIONE | | 著者 | Burke, J.P.W.G, Kinsley, N, Sayed, M, Sewell, T, Dirr, H.W. | | 登録日 | 2007-08-30 | | 公開日 | 2007-12-18 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Arginine 15 stabilizes an S(N)Ar reaction transition state and the binding of anionic ligands at the active site of human glutathione transferase A1-1.
Biophys.Chem., 146, 2010
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2R6K
 | | Crystal structure of an I71V hGSTA1-1 mutant in complex with S-hexylglutathione | | 分子名称: | Glutathione S-transferase A1, S-HEXYLGLUTATHIONE | | 著者 | Dirr, H.W, Fisher, L, Burke, J.P.W.G, Sayed, M, Sewell, T. | | 登録日 | 2007-09-06 | | 公開日 | 2008-08-19 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | | 主引用文献 | The role of a topologically conserved isoleucine in glutathione transferase structure, stability and function.
Acta Crystallogr.,Sect.F, 66, 2010
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2B5W
 | | Crystal structure of D38C glucose dehydrogenase mutant from Haloferax mediterranei | | 分子名称: | CITRATE ANION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, POTASSIUM ION, ... | | 著者 | Britton, K.L, Baker, P.J, Fisher, M, Ruzheinikov, S, Gilmour, D.J, Bonete, M.-J, Ferrer, J, Pire, C, Esclapez, J, Rice, D.W. | | 登録日 | 2005-09-29 | | 公開日 | 2006-04-04 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Analysis of protein solvent interactions in glucose dehydrogenase from the extreme halophile Haloferax mediterranei.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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2B5V
 | | Crystal structure of glucose dehydrogenase from Haloferax mediterranei | | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, glucose dehydrogenase | | 著者 | Britton, K.L, Baker, P.J, Fisher, M, Ruzheinikov, S, Gilmour, D.J, Bonete, M.-J, Ferrer, J, Pire, C, Esclapez, J, Rice, D.W. | | 登録日 | 2005-09-29 | | 公開日 | 2006-04-04 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Analysis of protein solvent interactions in glucose dehydrogenase from the extreme halophile Haloferax mediterranei.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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3SXS
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3SXR
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1F8G
 | | THE X-RAY STRUCTURE OF NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE FROM RHODOSPIRILLUM RUBRUM COMPLEXED WITH NAD+ | | 分子名称: | NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | 著者 | Buckley, P.A, Baz Jackson, J, Schneider, T, White, S.A, Rice, D.W, Baker, P.J. | | 登録日 | 2000-06-30 | | 公開日 | 2001-06-30 | | 最終更新日 | 2017-09-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Protein-protein recognition, hydride transfer and proton pumping in the transhydrogenase complex.
Structure Fold.Des., 8, 2000
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