2R3X

Crystal structure of an R15L hGSTA1-1 mutant complexed with S-hexyl-glutathione

Summary for 2R3X

Entry DOI	10.2210/pdb2r3x/pdb
Descriptor	Glutathione S-transferase A1, S-HEXYLGLUTATHIONE (3 entities in total)
Functional Keywords	human alpha class glutathione transferase 1-1, s-hexyl glutathione, x-ray crystal structure, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P08263
Total number of polymer chains	2
Total formula weight	52037.15
Authors	Burke, J.P.W.G.,Kinsley, N.,Sayed, M.,Sewell, T.,Dirr, H.W. (deposition date: 2007-08-30, release date: 2007-12-18, Last modification date: 2023-08-30)
Primary citation	Gildenhuys, S.,Dobreva, M.,Kinsley, N.,Sayed, Y.,Burke, J.,Pelly, S.,Gordon, G.P.,Sayed, M.,Sewell, T.,Dirr, H.W. Arginine 15 stabilizes an S(N)Ar reaction transition state and the binding of anionic ligands at the active site of human glutathione transferase A1-1. Biophys.Chem., 146:118-125, 2010 Cited by PubMed: 19959275 DOI: 10.1016/j.bpc.2009.11.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation