7PIM
| Partial structure of tyrosine hydroxylase lacking the first 35 residues in complex with dopamine. | 分子名称: | FE (III) ION, L-DOPAMINE, Regulatory domain alpha-helix, ... | 著者 | Bueno-Carrasco, M.T, Cuellar, J, Santiago, C, Valpuesta, J.M, Martinez, A, Flydal, M.I. | 登録日 | 2021-08-20 | 公開日 | 2021-12-22 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | 主引用文献 | Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation. Nat Commun, 13, 2022
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6ZVP
| Atomic model of the EM-based structure of the full-length tyrosine hydroxylase in complex with dopamine (residues 40-497) in which the regulatory domain (residues 40-165) has been included only with the backbone atoms | 分子名称: | FE (III) ION, L-DOPAMINE, Tyrosine 3-monooxygenase | 著者 | Bueno-Carrasco, M.T, Cuellar, J, Santiago, C, Valpuesta, J.M, Martinez, A, Flydal, M.I. | 登録日 | 2020-07-27 | 公開日 | 2021-11-17 | 最終更新日 | 2022-02-02 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation. Nat Commun, 13, 2022
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6ZZU
| Partial structure of the substrate-free tyrosine hydroxylase (apo-TH). | 分子名称: | FE (III) ION, Tyrosine 3-monooxygenase | 著者 | Bueno-Carrasco, M.T, Cuellar, J, Santiago, C, Valpuesta, J.M, Martinez, A, Flydal, M.I. | 登録日 | 2020-08-05 | 公開日 | 2021-11-17 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation. Nat Commun, 13, 2022
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7A2G
| Full-length structure of the substrate-free tyrosine hydroxylase (apo-TH). | 分子名称: | FE (III) ION, Tyrosine 3-monooxygenase | 著者 | Bueno-Carrasco, M.T, Cuellar, J, Santiago, C, Flydal, M.I, Martinez, A, Valpuesta, J.M. | 登録日 | 2020-08-17 | 公開日 | 2021-12-01 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation. Nat Commun, 13, 2022
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6ZN2
| Partial structure of tyrosine hydroxylase in complex with dopamine showing the catalytic domain and an alpha-helix from the regulatory domain involved in dopamine binding. | 分子名称: | FE (III) ION, L-DOPAMINE, SER-LEU-ILE-GLU-ASP-ALA-ARG-LYS-GLU-ARG-GLU-ALA-ALA-VAL-ALA-ALA-ALA-ALA, ... | 著者 | Bueno-Carrasco, M.T, Cuellar, J, Santiago, C, Valpuesta, J.M, Martinez, A, Flydal, M.I. | 登録日 | 2020-07-06 | 公開日 | 2021-12-08 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation. Nat Commun, 13, 2022
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8C89
| SARS-CoV-2 spike in complex with the 17T2 neutralizing antibody Fab fragment (local refinement of RBD and Fab) | 分子名称: | 17T2 Fab heavy chain, 17T2 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Modrego, A, Carlero, D, Bueno-Carrasco, M.T, Santiago, C, Carolis, C, Arranz, R, Blanco, J, Magri, G. | 登録日 | 2023-01-19 | 公開日 | 2024-01-10 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (4.41 Å) | 主引用文献 | A monoclonal antibody targeting a large surface of the receptor binding motif shows pan-neutralizing SARS-CoV-2 activity. Nat Commun, 15, 2024
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6QB8
| Human CCT:mLST8 complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, ... | 著者 | Cuellar, J, Santiago, C, Ludlam, W.G, Bueno-Carrasco, M.T, Valpuesta, J.M, Willardson, B.M. | 登録日 | 2018-12-20 | 公開日 | 2019-07-03 | 最終更新日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (3.97 Å) | 主引用文献 | Structural and functional analysis of the role of the chaperonin CCT in mTOR complex assembly. Nat Commun, 10, 2019
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8A8U
| Mycobacterium tuberculosis ClpC1 hexamer structure | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpC1, Bound polypeptide | 著者 | Felix, J, Fraga, H, Gragera, M, Bueno, T, Weinhaeupl, K. | 登録日 | 2022-06-24 | 公開日 | 2022-10-26 | 最終更新日 | 2022-11-23 | 実験手法 | ELECTRON MICROSCOPY (3.62 Å) | 主引用文献 | Structure of the drug target ClpC1 unfoldase in action provides insights on antibiotic mechanism of action. J.Biol.Chem., 298, 2022
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8A8V
| Mycobacterium tuberculosis ClpC1 hexamer structure bound to the natural product antibiotic Cyclomarin | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpC1, Bound polypeptide | 著者 | Felix, J, Fraga, H, Gragera, M, Bueno, T, Weinhaeupl, K. | 登録日 | 2022-06-24 | 公開日 | 2022-10-26 | 最終更新日 | 2022-11-23 | 実験手法 | ELECTRON MICROSCOPY (3.34 Å) | 主引用文献 | Structure of the drug target ClpC1 unfoldase in action provides insights on antibiotic mechanism of action. J.Biol.Chem., 298, 2022
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8A8W
| Mycobacterium tuberculosis ClpC1 hexamer structure bound to the natural product antibiotic Ecumycin (class 1) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpC1, Bound polypeptide | 著者 | Felix, J, Fraga, H, Gragera, M, Bueno, T, Weinhaeupl, K. | 登録日 | 2022-06-24 | 公開日 | 2022-10-26 | 最終更新日 | 2022-11-23 | 実験手法 | ELECTRON MICROSCOPY (4.29 Å) | 主引用文献 | Structure of the drug target ClpC1 unfoldase in action provides insights on antibiotic mechanism of action. J.Biol.Chem., 298, 2022
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