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6V2E
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BU of 6v2e by Molmil
Crystal structure of the human CLR:RAMP2 extracellular domain heterodimer with bound high-affinity adrenomedullin S45R/K46L/S48G/Q50W variant
分子名称: ADM, AMINO GROUP, FORMIC ACID, ...
著者Booe, J.M, Pioszak, A.A.
登録日2019-11-22
公開日2020-08-05
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Picomolar Affinity Antagonist and Sustained Signaling Agonist Peptide Ligands for the Adrenomedullin and Calcitonin Gene-Related Peptide Receptors.
Acs Pharmacol Transl Sci, 3, 2020
5V6Y
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BU of 5v6y by Molmil
Crystal structure of the human CLR:RAMP1 extracellular domain heterodimer with bound high-affinity and altered selectivity adrenomedullin variant
分子名称: ADM, Maltose-binding periplasmic protein,Receptor activity-modifying protein 1,Calcitonin gene-related peptide type 1 receptor, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
著者Pioszak, A, Booe, J.
登録日2017-03-17
公開日2018-01-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Probing the Mechanism of Receptor Activity-Modifying Protein Modulation of GPCR Ligand Selectivity through Rational Design of Potent Adrenomedullin and Calcitonin Gene-Related Peptide Antagonists.
Mol. Pharmacol., 93, 2018
4RWF
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BU of 4rwf by Molmil
Crystal structure of the CLR:RAMP2 extracellular domain heterodimer with bound adrenomedullin
分子名称: 1,2-ETHANEDIOL, Adrenomedullin, Maltose transporter subunit, ...
著者Booe, J, Pioszak, A.
登録日2014-12-03
公開日2015-05-20
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor.
Mol.Cell, 58, 2015
4RWG
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BU of 4rwg by Molmil
Crystal structure of the CLR:RAMP1 extracellular domain heterodimer with bound high affinity CGRP analog
分子名称: CGRP analog, MAGNESIUM ION, Maltose-binding periplasmic protein, ...
著者Booe, J, Pioszak, A.
登録日2014-12-03
公開日2015-05-20
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.44 Å)
主引用文献Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor.
Mol.Cell, 58, 2015
6D1U
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BU of 6d1u by Molmil
Crystal structure of the human CLR:RAMP1 extracellular domain heterodimer in complex with adrenomedullin 2/intermedin
分子名称: ADM2, Maltose-binding periplasmic protein,Receptor activity-modifying protein 1,Calcitonin gene-related peptide type 1 receptor, SODIUM ION, ...
著者Pioszak, A, Roehrkasse, A.
登録日2018-04-12
公開日2018-09-05
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structure-function analyses reveal a triple beta-turn receptor-bound conformation of adrenomedullin 2/intermedin and enable peptide antagonist design.
J. Biol. Chem., 293, 2018

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件を2024-09-04に公開中

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