6V2E
Crystal structure of the human CLR:RAMP2 extracellular domain heterodimer with bound high-affinity adrenomedullin S45R/K46L/S48G/Q50W variant
Summary for 6V2E
| Entry DOI | 10.2210/pdb6v2e/pdb |
| Related PRD ID | PRD_900001 |
| Descriptor | Maltose/maltodextrin-binding periplasmic protein,Receptor activity-modifying protein 2,Calcitonin gene-related peptide type 1 receptor, ADM, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ... (6 entities in total) |
| Functional Keywords | class b gpcr, peptide hormone, membrane protein |
| Biological source | Escherichia coli (strain K12) More |
| Total number of polymer chains | 2 |
| Total formula weight | 68664.85 |
| Authors | Booe, J.M.,Pioszak, A.A. (deposition date: 2019-11-22, release date: 2020-08-05, Last modification date: 2023-10-11) |
| Primary citation | Booe, J.M.,Warner, M.L.,Pioszak, A.A. Picomolar Affinity Antagonist and Sustained Signaling Agonist Peptide Ligands for the Adrenomedullin and Calcitonin Gene-Related Peptide Receptors. Acs Pharmacol Transl Sci, 3:759-772, 2020 Cited by PubMed: 32832875DOI: 10.1021/acsptsci.0c00031 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.83 Å) |
Structure validation
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