4A7J
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![BU of 4a7j by Molmil](/molmil-images/mine/4a7j) | Symmetric Dimethylation of H3 Arginine 2 is a Novel Histone Mark that Supports Euchromatin Maintenance | 分子名称: | HISTONE H3.1T, WD REPEAT-CONTAINING PROTEIN 5 | 著者 | Migliori, V, Muller, J, Phalke, S, Low, D, Bezzi, M, ChuenMok, W, Gunaratne, J, Capasso, P, Bassi, C, Cecatiello, V, DeMarco, A, Blackstock, W, Kuznetsov, V, Amati, B, Mapelli, M, Guccione, E. | 登録日 | 2011-11-14 | 公開日 | 2012-01-11 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Symmetric Dimethylation of H3R2 is a Newly Identified Histone Mark that Supports Euchromatin Maintenance Nat.Struct.Mol.Biol., 19, 2012
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8BN8
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![BU of 8bn8 by Molmil](/molmil-images/mine/8bn8) | METTL3-METTL14 heterodimer bound to the SAM competitive small molecule inhibitor STM3006 | 分子名称: | 2-[[4-(6-bromanyl-2~{H}-indazol-4-yl)-1,2,3-triazol-1-yl]methyl]-6-[(4,4-dimethylpiperidin-1-yl)methyl]imidazo[1,2-a]pyridine, N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit | 著者 | Pilka, E.S, Thomas, B, Blackaby, W, Hardick, D, Feeney, K, Ridgill, M, Rotty, B, Rausch, O. | 登録日 | 2022-11-13 | 公開日 | 2023-09-20 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.213 Å) | 主引用文献 | Inhibition of METTL3 Results in a Cell-Intrinsic Interferon Response That Enhances Antitumor Immunity. Cancer Discov, 13, 2023
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7O2I
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![BU of 7o2i by Molmil](/molmil-images/mine/7o2i) | METTL3-METTL14 heterodimer bound to the SAM competitive small molecule inhibitor STM2457 | 分子名称: | DIMETHYL SULFOXIDE, N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit, ... | 著者 | Pilka, E.S, Blackaby, W, Hardick, D, Harper, C, Hewstone, D, Ridgill, M, Rotty, B, Rausch, O. | 登録日 | 2021-03-30 | 公開日 | 2021-04-14 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia. Nature, 593, 2021
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7TZL
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![BU of 7tzl by Molmil](/molmil-images/mine/7tzl) | The DH dehydratase domain of AlnB | 分子名称: | 3-oxoacyl-[acyl-carrier-protein] reductase | 著者 | Swain, K, Blackson, W, Wang, B, Zhao, H, Nannenga, B.L. | 登録日 | 2022-02-16 | 公開日 | 2023-02-22 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | The programming of alpha,beta-polyene biosynthesis by a bacterial iterative type I polyketide synthase To Be Published
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5IT5
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![BU of 5it5 by Molmil](/molmil-images/mine/5it5) | Thermus thermophilus PilB core ATPase region | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, ATP binding motif-containing protein PilF, MAGNESIUM ION, ... | 著者 | Mancl, J, Robinson, H, Black, W, Yang, Z, Schubot, F. | 登録日 | 2016-03-16 | 公開日 | 2016-10-19 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.648 Å) | 主引用文献 | Crystal Structure of a Type IV Pilus Assembly ATPase: Insights into the Molecular Mechanism of PilB from Thermus thermophilus. Structure, 24, 2016
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6YKG
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![BU of 6ykg by Molmil](/molmil-images/mine/6ykg) | |
6NO9
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![BU of 6no9 by Molmil](/molmil-images/mine/6no9) | PIM1 in complex with Cpd16 (5-amino-N-(5-((4R,5R)-4-amino-5-fluoroazepan-1-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide) | 分子名称: | 5-amino-N-{5-[(4R,5R)-4-amino-5-fluoroazepan-1-yl]-1-methyl-1H-pyrazol-4-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide, GLYCEROL, PHOSPHATE ION, ... | 著者 | Murray, J.M, Noland, C. | 登録日 | 2019-01-15 | 公開日 | 2019-02-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.712 Å) | 主引用文献 | Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma. J. Med. Chem., 62, 2019
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6I3U
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![BU of 6i3u by Molmil](/molmil-images/mine/6i3u) | |
8OEG
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![BU of 8oeg by Molmil](/molmil-images/mine/8oeg) | PDE4B bound to MAPI compound 92a | 分子名称: | MAGNESIUM ION, ZINC ION, [(1~{S})-2-[3,5-bis(chloranyl)-1-oxidanyl-pyridin-4-yl]-1-(3,4-dimethoxyphenyl)ethyl] 5-[[[(1~{R})-2-[[(3~{R})-1-azabicyclo[2.2.2]octan-3-yl]oxy]-2-oxidanylidene-1-phenyl-ethyl]amino]methyl]thiophene-2-carboxylate, ... | 著者 | Rizzi, A, Armani, E. | 登録日 | 2023-03-10 | 公開日 | 2023-04-26 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Optimization of M 3 Antagonist-PDE4 Inhibitor (MAPI) Dual Pharmacology Molecules for the Treatment of COPD. J.Med.Chem., 66, 2023
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