8OEG

PDE4B bound to MAPI compound 92a

Summary for 8OEG

Entry DOI	10.2210/pdb8oeg/pdb
Descriptor	cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	human phosphodiesterase 4b, mapi compound, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	49260.09
Authors	Rizzi, A.,Armani, E. (deposition date: 2023-03-10, release date: 2023-04-26, Last modification date: 2023-11-08)
Primary citation	Rizzi, A.,Amari, G.,Pivetti, F.,Delcanale, M.,Amadei, F.,Pappani, A.,Fornasari, L.,Villetti, G.,Marchini, G.,Pisano, A.R.,Pitozzi, V.,Pittelli, M.G.,Trevisani, M.,Salvadori, M.,Cenacchi, V.,Fioni, A.,Puccini, P.,Civelli, M.,Patacchini, R.,Baker-Glenn, C.,Van de Poel, H.,Blackaby, W.,Nash, K.,Armani, E. Optimization of M 3 Antagonist-PDE4 Inhibitor (MAPI) Dual Pharmacology Molecules for the Treatment of COPD. J.Med.Chem., 66:11476-11497, 2023 Cited by PubMed: 37561958 DOI: 10.1021/acs.jmedchem.3c01012 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.89 Å)

Structure validation