8OEG
PDE4B bound to MAPI compound 92a
Summary for 8OEG
Entry DOI | 10.2210/pdb8oeg/pdb |
Descriptor | cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | human phosphodiesterase 4b, mapi compound, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 49260.09 |
Authors | Rizzi, A.,Armani, E. (deposition date: 2023-03-10, release date: 2023-04-26, Last modification date: 2023-11-08) |
Primary citation | Rizzi, A.,Amari, G.,Pivetti, F.,Delcanale, M.,Amadei, F.,Pappani, A.,Fornasari, L.,Villetti, G.,Marchini, G.,Pisano, A.R.,Pitozzi, V.,Pittelli, M.G.,Trevisani, M.,Salvadori, M.,Cenacchi, V.,Fioni, A.,Puccini, P.,Civelli, M.,Patacchini, R.,Baker-Glenn, C.,Van de Poel, H.,Blackaby, W.,Nash, K.,Armani, E. Optimization of M 3 Antagonist-PDE4 Inhibitor (MAPI) Dual Pharmacology Molecules for the Treatment of COPD. J.Med.Chem., 66:11476-11497, 2023 Cited by PubMed: 37561958DOI: 10.1021/acs.jmedchem.3c01012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.89 Å) |
Structure validation
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