8OEG
PDE4B bound to MAPI compound 92a
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | polymer | 421 | 48442.7 | 1 | UniProt (Q07343) Pfam (PF18100) Pfam (PF00233) In PDB | Homo sapiens (human) | DPDE4,PDE32 |
2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
3 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
4 | A | [(1~{S})-2-[3,5-bis(chloranyl)-1-oxidanyl-pyridin-4-yl]-1-(3,4-dimethoxyphenyl)ethyl] 5-[[[(1~{R})-2-[[(3~{R})-1-azabicyclo[2.2.2]octan-3-yl]oxy]-2-oxidanylidene-1-phenyl-ethyl]amino]methyl]thiophene-2-carboxylate | non-polymer | 727.7 | 1 | Chemie (VL9) | |||
5 | water | water | 18.0 | 116 | Chemie (HOH) |
Sequence modifications
A: 246 - 659 (UniProt: Q07343)
PDB | External Database | Details |
---|---|---|
Met 245 | - | initiating methionine |
Lys 295 | Ser 290 | conflict |
Val 296 | Pro 291 | conflict |
Ala 298 | Gln 293 | conflict |
Glu 299 | Lys 294 | conflict |
Glu 300 | Asp 295 | conflict |
- | Arg 296 | deletion |
- | Glu 297 | deletion |
- | Lys 298 | deletion |
- | Lys 299 | deletion |
- | Lys 300 | deletion |
Ala 301 | Lys 301 | conflict |
Pro 302 | Gln 302 | conflict |
Pro 304 | Leu 304 | conflict |
His 660 | - | expression tag |
His 661 | - | expression tag |
His 662 | - | expression tag |
His 663 | - | expression tag |
His 664 | - | expression tag |
His 665 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 48442.7 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 817.4 | |
All* | Total formula weight | 49260.1 |