9MGY
 
 | | Cryo-EM structure of Human NLRP3 complex with compound 1 | | 分子名称: | (2M)-2-(6-{[(3R)-1-methylpiperidin-3-yl]amino}pyridazin-3-yl)-5-(trifluoromethyl)phenol, ADENOSINE-5'-TRIPHOSPHATE, NACHT, ... | | 著者 | Mammoliti, O, Carbajo, R.J, Perez-Benito, L, Yu, X, Prieri, M.L.C, Bontempi, L, Embrechts, S, Paesmans, I, Bassi, M, Bhattacharya, A, Roman, S.C, Hoog, S.D, Demin, S, Gijsen, H.J.M, Hache, G, Jacobs, T, Jerhaoui, S, Leenaerts, J, Lutter, F.H, Matico, R, Oehlrich, D, Perrier, M, Ryabchuk, P, Schepens, W, Sharma, S, Somers, M, Suarez, J, Surkyn, M, Opdenbosch, N.V, Verhulst, T, Bottelbergs, A. | | 登録日 | 2024-12-11 | | 公開日 | 2025-02-26 | | 最終更新日 | 2025-03-12 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Discovery of Potent and Brain-Penetrant Bicyclic NLRP3 Inhibitors with Peripheral and Central In Vivo Activity.
J.Med.Chem., 68, 2025
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9MIG
 | | Cryo-EM structure of Human NLRP3 complex with compound 3 | | 分子名称: | (2P)-2-(4-{[(3R)-1-methylpiperidin-3-yl]amino}-5,6,7,8-tetrahydrophthalazin-1-yl)-5-(trifluoromethyl)phenol, ADENOSINE-5'-TRIPHOSPHATE, NACHT, ... | | 著者 | Mammoliti, O, Carbajo, R.J, Perez-Benito, L, Yu, X, Prieri, M.L.C, Bontempi, L, Embrechts, S, Paesmans, I, Bassi, M, Bhattacharya, A, Roman, S.C, Hoog, S.D, Demin, S, Gijsen, H.J.M, Hache, G, Jacobs, T, Jerhaoui, S, Leenaerts, J, Lutter, F.H, Matico, R, Oehlrich, D, Perrier, M, Ryabchuk, P, Schepens, W, Sharma, S, Somers, M, Suarez, J, Surkyn, M, Opdenbosch, N.V, Verhulst, T, Bottelbergs, A. | | 登録日 | 2024-12-12 | | 公開日 | 2025-02-26 | | 最終更新日 | 2025-03-12 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Discovery of Potent and Brain-Penetrant Bicyclic NLRP3 Inhibitors with Peripheral and Central In Vivo Activity.
J.Med.Chem., 68, 2025
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2G9J
 | | Complex of TM1a(1-14)Zip with TM9a(251-284): a model for the polymerization domain ("overlap region") of tropomyosin, Northeast Structural Genomics Target OR9 | | 分子名称: | Tropomyosin 1 alpha chain, Tropomyosin 1 alpha chain/General control protein GCN4 | | 著者 | Greenfield, N.J, Huang, Y.J, Swapna, G.V.T, Bhattacharya, A, Singh, A, Montelione, G.T, Hitchcock-DeGregori, S.E, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2006-03-06 | | 公開日 | 2006-11-07 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution NMR Structure of the Junction between Tropomyosin Molecules: Implications for Actin Binding and Regulation.
J.Mol.Biol., 364, 2006
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6C68
 | | MHC-independent t cell receptor A11 | | 分子名称: | T-cell receptor alpha chain, T-cell receptor beta chain | | 著者 | Lu, J, Van Laethem, F, Saba, I, Chu, J, Bhattacharya, A, Love, N.C, Tikhonova, A, Radaev, S, Sun, X, Ko, A, Arnon, T, Shifrut, E, Friedman, N, Weng, N, Singer, A, Sun, P.D. | | 登録日 | 2018-01-18 | | 公開日 | 2019-01-30 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | | 主引用文献 | Structure of MHC-Independent TCRs and Their Recognition of Native Antigen CD155.
J Immunol., 204, 2020
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4KUJ
 | | Structural and functional characterization of a novel Alpha Kinase from Entamoeba histolytica | | 分子名称: | DI(HYDROXYETHYL)ETHER, Protein kinase, putative, ... | | 著者 | Rehman, S.A.A, Tarique, K.F, Bhattacharya, A, Gourinath, S, Mansuri, M.S. | | 登録日 | 2013-05-22 | | 公開日 | 2014-05-28 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | Structural and functional characterization of a novel Alpha Kinase from Entamoeba histolytica
To be Published
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5XYL
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4NL0
 | | Structural and functional characterization of a novel Alpha Kinase in complex with ADP from Entamoeba histolytica | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Protein kinase, putative, ... | | 著者 | Tarique, K.F, Rehman, S.A.A, Bhattacharya, A, Gourinath, S, Mansuri, M.S. | | 登録日 | 2013-11-13 | | 公開日 | 2014-11-19 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | | 主引用文献 | Structural and functional characterization of a novel Alpha Kinase in complex with ADP from Entamoeba histolytica
To be Published
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6U6X
 | | Human SAMHD1 bound to deoxyribo(C*G*C*C*T)-oligonucleotide | | 分子名称: | DNA SC-GS-SC-SC-DT, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ZINC ION | | 著者 | Taylor, A.B, Bhattacharya, A, Wang, Z, Ivanov, D.N. | | 登録日 | 2019-08-30 | | 公開日 | 2020-09-02 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | | 主引用文献 | Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification.
Nat Commun, 12, 2021
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6U6Y
 | | Human SAMHD1 bound to ribo(CGCCU)-oligonucleotide | | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, RNA CGCCU, ... | | 著者 | Taylor, A.B, Bhattacharya, A, Wang, Z, Ivanov, D.N. | | 登録日 | 2019-08-30 | | 公開日 | 2020-09-02 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | | 主引用文献 | Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification.
Nat Commun, 12, 2021
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1JFK
 | | MINIMUM ENERGY REPRESENTATIVE STRUCTURE OF A CALCIUM BOUND EF-HAND PROTEIN FROM ENTAMOEBA HISTOLYTICA | | 分子名称: | CALCIUM ION, CALCIUM-BINDING PROTEIN | | 著者 | Atreya, H.S, Sahu, S.C, Bhattacharya, A, Chary, K.V.R, Govil, G. | | 登録日 | 2001-06-21 | | 公開日 | 2001-12-19 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR derived solution structure of an EF-hand calcium-binding protein from Entamoeba Histolytica.
Biochemistry, 40, 2001
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1JFJ
 | | NMR SOLUTION STRUCTURE OF AN EF-HAND CALCIUM BINDING PROTEIN FROM ENTAMOEBA HISTOLYTICA | | 分子名称: | CALCIUM-BINDING PROTEIN | | 著者 | Atreya, H.S, Sahu, S.C, Bhattacharya, A, Chary, K.V.R, Govil, G. | | 登録日 | 2001-06-20 | | 公開日 | 2001-12-19 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR derived solution structure of an EF-hand calcium-binding protein from Entamoeba Histolytica.
Biochemistry, 40, 2001
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2M7K
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2LC5
 | | Calmodulin-like Protein from Entamoeba histolytica: Solution Structure and Calcium-Binding Properties of a Partially Folded Protein | | 分子名称: | CALCIUM ION, Calmodulin, putative | | 著者 | Rout, A.K, Padhan, N, Barnwal, R.P, Bhattacharya, A, Chary, K.V. | | 登録日 | 2011-04-23 | | 公開日 | 2011-06-08 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Calmodulin like protein from Entamoeba histolytica: solution structure and calcium binding properties of a partially folded protein.
Biochemistry, 50, 2010
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2M7M
 | | N-terminal domain of EhCaBP1 structure | | 分子名称: | CALCIUM ION, Calcium-binding protein | | 著者 | Chary, K.V, Rout, A.K, Patel, S, Bhattacharya, A. | | 登録日 | 2013-04-26 | | 公開日 | 2013-06-19 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Functional Manipulation of a Calcium-binding Protein from Entamoeba histolytica Guided by Paramagnetic NMR.
J.Biol.Chem., 288, 2013
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2M7N
 | | C-terminal structure of (Y81F)-EhCaBP1 | | 分子名称: | CALCIUM ION, Calcium-binding protein | | 著者 | Chary, K.V, Rout, A.K, Patel, S, Bhattacharya, A. | | 登録日 | 2013-04-26 | | 公開日 | 2013-06-19 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Functional Manipulation of a Calcium-binding Protein from Entamoeba histolytica Guided by Paramagnetic NMR.
J.Biol.Chem., 288, 2013
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4QNB
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4WYM
 | | Structural basis of HIV-1 capsid recognition by CPSF6 | | 分子名称: | Capsid protein p24, ISOFORM 2 OF CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 6 | | 著者 | Battacharya, A, Taylor, A.B, Hart, P.J, Ivanov, D.N. | | 登録日 | 2014-11-17 | | 公開日 | 2014-12-17 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural basis of HIV-1 capsid recognition by PF74 and CPSF6.
Proc.Natl.Acad.Sci.USA, 111, 2014
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6YVA
 | | PLpro-C111S with mISG15 | | 分子名称: | Replicase polyprotein 1a, Ubiquitin-like protein ISG15, ZINC ION | | 著者 | Shin, D, Dikic, I. | | 登録日 | 2020-04-28 | | 公開日 | 2020-05-13 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (3.18 Å) | | 主引用文献 | Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity.
Nature, 587, 2020
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1L7B
 | | Solution NMR Structure of BRCT Domain of T. Thermophilus: Northeast Structural Genomics Consortium Target WR64TT | | 分子名称: | DNA LIGASE | | 著者 | Sahota, G, Dixon, B.L, Huang, Y.P, Aramini, J, Monleon, D, Bhattacharya, D, Swapna, G.V.T, Yin, C, Xiao, R, Anderson, S, Tejero, R, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2002-03-14 | | 公開日 | 2003-09-16 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution NMR Structure of the Brct Domain from Thermus Thermophilus DNA Ligase
To be Published
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9MIE
 | | Human NLRP3 complex with compound 2 in the closed hexamer | | 分子名称: | (2P)-2-(4-{[(3R)-1-methylpiperidin-3-yl]amino}-6,7-dihydro-5H-cyclopenta[d]pyridazin-1-yl)-5-(trifluoromethyl)phenol, ADENOSINE-5'-TRIPHOSPHATE, NACHT, ... | | 著者 | Mammoliti, O, Carbajo, R.J, Perez-Benito, L, Yu, X. | | 登録日 | 2024-12-12 | | 公開日 | 2025-02-26 | | 最終更新日 | 2025-03-12 | | 実験手法 | ELECTRON MICROSCOPY (3.93 Å) | | 主引用文献 | Discovery of Potent and Brain-Penetrant Bicyclic NLRP3 Inhibitors with Peripheral and Central In Vivo Activity.
J.Med.Chem., 68, 2025
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9FGM
 | | Cryo-EM structure of Legionella effector SdeC (3D flexible refinement) | | 分子名称: | SdeC | | 著者 | Weng, T.-H, Misra, M, Chen, W, Safarian, S, Kudryashev, M, Dikic, I. | | 登録日 | 2024-05-24 | | 公開日 | 2025-06-04 | | 最終更新日 | 2025-06-18 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | BAR-like C-terminal domain of Legionella SidE family is crucial for its membrane localization and secretion
To Be Published
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9FGJ
 | | Cryo-EM structure of Legionella effector SdeC (PDE-mART domain) | | 分子名称: | SdeC | | 著者 | Weng, T.-H, Misra, M, Chen, W, Safarian, S, Kudryashev, M, Dikic, I. | | 登録日 | 2024-05-24 | | 公開日 | 2025-06-04 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | BAR-like C-terminal domain of Legionella SidE family is crucial for its membrane localization and secretion
To Be Published
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4LKA
 | | Crystal Structure of MOZ double PHD finger histone H3K9ac complex | | 分子名称: | Histone H3.1, Histone acetyltransferase KAT6A, ZINC ION | | 著者 | Dreveny, I, Deeves, S.E, Yue, B, Heery, D.M. | | 登録日 | 2013-07-07 | | 公開日 | 2013-10-16 | | 最終更新日 | 2024-11-27 | | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | | 主引用文献 | The double PHD finger domain of MOZ/MYST3 induces alpha-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification.
Nucleic Acids Res., 42, 2014
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4LLB
 | | Crystal Structure of MOZ double PHD finger histone H3K14ac complex | | 分子名称: | Histone H3.1, Histone acetyltransferase KAT6A, ZINC ION | | 著者 | Dreveny, I, Deeves, S.E, Yue, B, Heery, D.M. | | 登録日 | 2013-07-09 | | 公開日 | 2013-10-16 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | The double PHD finger domain of MOZ/MYST3 induces alpha-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification.
Nucleic Acids Res., 42, 2014
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4LJN
 | | Crystal Structure of MOZ double PHD finger | | 分子名称: | Histone acetyltransferase KAT6A, ZINC ION | | 著者 | Dreveny, I, Deeves, S.E, Yue, B, Heery, D.M. | | 登録日 | 2013-07-05 | | 公開日 | 2013-10-16 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | The double PHD finger domain of MOZ/MYST3 induces alpha-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification.
Nucleic Acids Res., 42, 2014
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